Jerzy Szablowski @jerzyszablowski.bsky.social · 15/05/2026Tenure - deeply grateful to the students, postdocs, mentors, collaborators, and colleagues who made this possible. The next chapter will expand the lab towards a couple of new directions, including multiplexed interfacing with deep tissues and reengineering drug discovery. 030
Reposted by Jerzy SzablowskiSandra Poulson @sandrapoulson.bsky.social · 05/05/2026I had the BEST time at #CanadianPain26 this year. Thank you SO much to everyone who came to my posters featuring our work with @jerzyszablowski.bsky.social and the Martin & Mogil collab paper. I hope to see you all again at future Canadian Pain meetings! 011
Reposted by Jerzy SzablowskiSandra Poulson @sandrapoulson.bsky.social · 22/03/2026#USASP_2026 Come see some cool research using novel tools to measure neuronal activity by the Szablowski Lab at Rice @jerzyszablowski.bsky.socialmedia.tenor.coma man in a suit and tie is smiling and says you 're gonna love itALT: a man in a suit and tie is smiling and says you 're gonna love it 011
Reposted by Jerzy SzablowskiVinny Costa @vincentcostaphd.bsky.social · 27/02/2026Because my lab was located at a @nprcnews.bsky.social we had resources to move fast and within months Jerzy and Sin had redesigned a version of the RMA protein for IG1 Fc receptor in primates they called, NHP-RMAs. We injected the protein into the brain and O.M.G it worked inspiring this tweet. 121
Reposted by Jerzy SzablowskiVinny Costa @vincentcostaphd.bsky.social · 27/02/2026Monitoring gene expression in the brain with a simple blood test? In collaboration with @jerzyszablowski.bsky.social & his lab we figured out how to do it nonhuman primates using noninvasive neuroengineering of synthetic serum markers. nam11.safelinks.protection.outlook.com?url=https%3A...nam11.safelinks.protection.outlook.comScienceDirect.com | Science, health and medical journals, full text articles and books. 56733
Reposted by Jerzy SzablowskiRice Neuroengineering Initiative @riceneuro.bsky.social · 03/12/2025How can serum marker tests be made more sensitive? The lab of @jerzyszablowski.bsky.social shows that editing markers in vivo to reduce their half-life can provide more sensitive measurement of gene expression dynamics. Read more: www.pnas.org/doi/10.1073/...pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans... 031
Jerzy Szablowski @jerzyszablowski.bsky.social · 18/06/2025Neat www.nature.com/articles/s41...nature.comA humanized NOVA1 splicing factor alters mouse vocal communications - Nature CommunicationsThe neuron-specific RNA binding protein NOVA1 has a single amino acid substitution unique to modern humans. Here, the authors characterize the evolutional specificity and the function of the substitut... 020
Jerzy Szablowski @jerzyszablowski.bsky.social · 04/06/2025Addgene now has the NHP-RMAs available - the synthetic serum markers for measuring transgene and Cre-dependent expression, from the preprint (www.biorxiv.org/content/10.1...) with @vincentcostaphd.bsky.social lab. plasmids for order: www.addgene.org/browse/artic...addgene.orgAddgene: Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains 085
Jerzy Szablowski @jerzyszablowski.bsky.social · 03/06/2025How can you know if gene delivery in a primate worked Typically through expensive scans or histology. With @vincentcostaphd.bsky.social and co-authors we made synthetic markers that monitor gene delivery and Cre-dependent expression with a blood test: www.biorxiv.org/content/10.1... 22710
Jerzy Szablowski @jerzyszablowski.bsky.social · 26/04/2025What is the next frontier in brain therapy? Small molecules act everywhere; our work targets brain regions with mm precision. Next frontier? Targeting microscale - neuronal connections, ensembles. Here, we test AAV9.retro for noninvasive transduction of neuronal projections. preprint comments 120
Reposted by Jerzy SzablowskiEd Boyden @eboyden3.bsky.social · 10/03/2025The MIT McGovern Institute’s story celebrating the 10th birthday of expansion microscopy (ExM). One highlight: ExM is not only easy to do, it’s easy to modify - so lots of people are altering and applying ExM for custom purposes, leading to unexpected innovations: mcgovern.mit.edu/2025/03/03/t... 06215
Reposted by Jerzy SzablowskiVinny Costa @vincentcostaphd.bsky.social · 07/03/2025Posting this image of neurons transfected to secrete proteins that @jerzyszablowski.bsky.social bioengineered to enable noninvasive monitoring of neuronal integrity in NHPs for #fluorescentfriday. This technology will eventually lead to improved treatments for neurodegenerative disorders. 14811
Jerzy Szablowski @jerzyszablowski.bsky.social · 17/02/2025We are starting our @ARIA_research Precision Neurotechnologies project and have two non-postdoc positions in neuroscience and bioengineering. This funding is independent of US government. Jobs: emdz.fa.us2.oraclecloud.com/hcmUI/Candid... More info: tinyurl.com/hwsnrwpe -- please RT -- 023
Jerzy Szablowski @jerzyszablowski.bsky.social · 06/02/2025Did you all start sciencing harder recently, or something? 010
Reposted by Jerzy SzablowskiAmanda Fanniff, PhD @amandafanniff.bsky.social · 24/01/2025A quick reminder: For every $1 of research funding, NIH generated $2.46 in economic activity. This includes funding jobs in all 50 states. This isn't a red/blue thing: 8.9 jobs per $1M in CA & 12 jobs per $1M in GA. #AcademicSky #PhDSky #MedSky #HealthSky #healthequity #SciComm bit.ly/40NkIc0unitedformedicalresearch.org 29983281
Jerzy Szablowski @jerzyszablowski.bsky.social · 21/01/2025I am looking forward to working with @LignaniLab_UCL and others on this @ARIA_research neurotechnologies grant. A ~$2.5m contribution to our lab's work that will help us make next generation noninvasive brain therapies for specific brain circuits. news.rice.edu/news/2025/ri...news.rice.edu 030
Reposted by Jerzy Szablowskiadamezracohen.bsky.social @adamezracohen.bsky.social · 12/12/2024If some calcium enters a dendrite, how far does it diffuse? Rebecca Frank Hayward (who is on the job market!) measured this. www.sciencedirect.com/science/arti... She combined a blue light-activated Ca++ channel with a red-fluorescent Ca++ sensor. The length constant is about 5 microns.sciencedirect.comAll-optical mapping of Ca2+ transport and homeostasis in dendritesCalcium mediates many important signals in dendrites. However, the basic transport properties of calcium in dendrites have been difficult to measure: … 2144
Reposted by Jerzy SzablowskiJohn Ngo @johntngo.bsky.social · 30/11/2024We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs. You can check out our pre-print here: tinyurl.com/27p7hyt9, and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71... 511943
Jerzy Szablowski @jerzyszablowski.bsky.social · 12/12/2024qPCR can measure expression of virtually any gene... in homogenized tissues. Here, we show an "in-vivo qPCR" equivalent, where we measure a sequence-specific transcript with synthetic serum markers and enzyme-based signal amplification. www.biorxiv.org/content/10.1... 084
Reposted by Jerzy SzablowskiMichael Fischbach @mfgrp.bsky.social · 11/12/2024Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55 23693294
Reposted by Jerzy SzablowskiEd Boyden @eboyden3.bsky.social · 03/12/2024"E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains." -CEO Andrew Payne e11.bio/news/roadmape11.bioE11 Bio Roadmap | E11 Bio 05010
Jerzy Szablowski @jerzyszablowski.bsky.social · 09/12/2024Our recent study now out in print at Nature Biotech: Gene expression in the mouse brain is measured with a simple blood draw go.nature.com/48NC0a5 rdcu.be/d1rY1go.nature.comEngineered serum markers for non-invasive monitoring of gene expression in the brain - Nature BiotechnologyGene expression in the mouse brain is measured with a simple blood draw. 010
Reposted by Jerzy SzablowskiAlice Ting @aliceyting.bsky.social · 04/12/2024Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation.. 33434138
Jerzy Szablowski @jerzyszablowski.bsky.social · 02/12/2024www.aria.org.uk/scalable-neu...aria.org.ukScalable Neural Interfaces – Opportunity seeds - ARIATo support scientific and technological breakthroughs, outside of programmes, ARIA Programme Directors can award opportunity seeds to support ambitious research aligned to the opportunity spaces they’... 000
Jerzy Szablowski @jerzyszablowski.bsky.social · 28/11/2024We have two postdoc positions coming up for early next year in NHP neuroscience with FUS-BBBO and molecular engineering foci. Let me know if you know someone interested! 030
Reposted by Jerzy SzablowskiRitu Raman @rituraman.bsky.social · 25/11/2024Excited to share a new review on Magnets for Mechanobiology - teamed up w/ fellow 🧲 enthusiasts from Boston/Madrid/Zurich/Singapore to share how we manipulate cellular microenvironments w/ magnetic fields! Thanks to @danielgmadrid11.bsky.social for bringing us together! doi.org/10.1002/aisy...doi.orgMagnetic Actuation for MechanomedicineIn this perspective, the emergence of magneto-mechanical actuation systems in biomedical research and mechanomedicine is explored. These materials, ranging from single particles to 3D scaffolds, enab... 0345
Jerzy Szablowski @jerzyszablowski.bsky.social · 21/11/2024We got a summary statement from NIH just 17 days after the study section. Is that a new record? 000
Jerzy Szablowski @jerzyszablowski.bsky.social · 19/11/2024I am looking forward to coming back to @MIT for Neurotech 2024 tomorrow in Bldg 46! I will talk about noninvasive interfacing with the brain, including new projects with our postdoc Sho Watanabe and collaborators @vincentcostaphd.bsky.social and Rui Chen (UCI). neurotech.mit.eduneurotech.mit.eduneurotech.mit.edu 001
Reposted by Jerzy SzablowskiMikhail Shapiro @mikhailshapiro.bsky.social · 18/11/2024What happens when you can take videos of acoustic proteins in 3D inside the body? 🧊 You can see things like the flow of CSF in the brain! 🧠 Congrats to Sunho Lee, co-senior author Claire Rabut, and colleagues on "Takoyaki" ultrasound. 🥟 #gasvesicles www.biorxiv.org/content/10.1... 1378
Jerzy Szablowski @jerzyszablowski.bsky.social · 15/11/2024www.nature.com/articles/s41...nature.comWhat will it take to get miRNA therapies to market? - Nature BiotechnologyThe Nobel Prize in medicine was awarded for the discovery of miRNA, but miRNA therapeutics have a long way to go before they outcompete other therapies. 000
Jerzy Szablowski @jerzyszablowski.bsky.social · 13/11/2024www.nature.com/articles/s41...nature.comBiotechs take multiplexing into animal models to accelerate drug discovery - Nature BiotechnologyCompanies are moving therapeutic testing from plastic wells into pooled in vivo screening, generating physiologically relevant data by screening many drug candidates at once in a single animal. 000