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Quinn Sievers

@quinnsievers.bsky.social
216 followers 165 following 341 posts

Instructor in Lymphoma at Memorial Sloan Kettering and postdoc in the Abdel-Wahab and Vinogradova labs | Big problems, small molecules 🏳️‍🌈

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Reposted by Quinn Sievers
Dr. D Boulware, MD MPH @drboulware.bsky.social · 01/10/2026
NIH Funding rate of Early Stage Investigators (ESI). 2025 was a major drop. 2026 will be worse.
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 20h
NIH’s shift to multiyear funding reduced the number of awards across a range of research areas. Grants reviewed by NIH panels that had "cancer" or "oncology" in their title dipped to around 1,590 in 2026, compared with 1,920 in 2024. Fewer grants funded means fewer shots on goal, fewer wins
The agency's shift to fully funding more grants upfront appears to have reduced the number of awards across a range of research areas. Grants reviewed by NIH panels that had "cancer" or "oncology" in their title dipped to around 1,590 in 2026, compared with 1,920 in 2024. Similarly, awards reviewed by vaccine-focused study sections dropped after steady year-to-year increases between 2018 and 2024, with 269 such grants awarded this year compared with 297 in 2024.
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Jonathan Wosen @jonathanwosen.bsky.social · 20h
What did NIH spend its budget on this fiscal year, and how has that changed due to Trump administration priorities? @aniloza.bsky.social, @jaspar.bsky.social, and I teamed up for @statnews.com to look at the agency's grants data. Here's what we learned 👇 www.statnews.com/2026/10/02/n...
statnews.com
NIH awarded all its grant funding, but delayed and opaque decisions stymied researchers
The NIH continued reducing grants involving health disparities, race, and ethnicity but made little progress toward other administration priorities in the 2026 fiscal year.
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Kimberly Beatty @beattylab.bsky.social · 28/09/2026
Please share: OHSU is hiring an Assistant Prof. in the Dept. of Chemical Physiology & Biochemistry. We are looking for a chemical biologist who will apply novel chemical tools in physiological systems. Apply online: www.ohsu.edu/human-resour... (Job # 2026-41667).
ohsu.edu
OHSU Faculty, Physician and Academic Jobs in Oregon
Find higher education faculty, physician and research jobs and build your academic health career at OHSU in Portland, Oregon.
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In Preparation @inprep.bsky.social · 29/09/2026
inpreparation.substack.com
Sixth Grant Resubmission Described As Most Faithful Adaptation Of The Odyssey
CHAPEL HILL, NC—Praising it as the definitive treatment of the source material, literary scholars confirmed Monday that Prof.
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Reposted by Quinn Sievers
ChimeraX @chimerax.ucsf.edu · 25/09/2026
Make natural language requests to ChimeraX with the new Pellaeon plugin developed by Yam Amir that works with many free and paid large language models. Get Pellaeon using ChimeraX menu Tools / More Tools.... cxtoolshed.rbvi.ucsf.edu/apps/chimera...
PAR1 molecular structure shown in ChimeraX using Pellaeon chat bot.
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Reposted by Quinn Sievers
Fred Hutch @fredhutch.org · 26/09/2026
Fred Hutch is recruiting an Assistant Professor in Cancer Prevention. We're seeking researchers focused on metabolism, nutrition, physical activity, toxicology and the biological mechanisms of carcinogenesis to advance cancer prevention science. Apply: apply.interfolio.com/191911
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Caroline Bartman @cbartman.bsky.social · 26/09/2026
Are there key discoveries made with spatial RNA seq? Or what are your favorite spatial rna seq papers? Pls reski!
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Caroline Bartman @cbartman.bsky.social · 28/09/2026
I love astrology because what do you mean my spirit animal is an analytical balance
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Mike Feigin 🥯 @mikefeigin.bsky.social · 23/09/2026
It is fucking exhausting to read a scientific paper.
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American Society of Hematology @ash.hematology.org · 23/09/2026
ASH is investing nearly $50 million in these opportunities as part of the #Fight4Hematology campaign, supporting 3,500+ awards. Hematology research careers start here: ow.ly/b6Hv50ZQL0M Share the link! #ASHAwards #HemeSky #MedSky #Fight4Hematology
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Addgene @addgene.bsky.social · 23/09/2026
Every Transfection-Ready DNA order is backed by whole-plasmid NGS — not Sanger, not a restriction digest. That same verified DNA arrives ready to pipette, the moment it lands on your bench. twp.ai/4hvlcY #NGS #QualityControl
Addgene graphic promoting Transfection-Ready DNA with the message “Backed by whole plasmid sequencing” on a dark blue background with stylized circular DNA illustrations.
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Adam Sperling, MD, PhD @adamssperling.bsky.social · 20/09/2026
Horrifying. What is wrong with these people? www.politico.com/news/2026/09...
politico.com
Trump asked budget chief to draft order bringing health research funding under his control
The move came after the NIH director refused Trump’s request to cut Harvard grants in an Oval Office meeting.
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Reposted by Quinn Sievers
In Preparation @inprep.bsky.social · 18/09/2026
inpreparation.substack.com
Regev Daughter Bags Science Fair Win, Edges Baking Soda Volcano With Single-Cell Atlas Of Murine Tumor Microenvironment
SOUTH SAN FRANCISCO, CA—Genentech head of Research and Early Development Aviv Regev confirmed Tuesday that her 12-year-old daughter independently conceived, designed, and executed a 450,000-cell…
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STAT @statnews.com · 10/09/2026
More than 20% of all cancer centers report shortages of five or more different medicines www.statnews.com/pharmalot/20...
statnews.com
Cancer medicines remain in short supply across the U.S., survey finds
An ongoing shortage of cancer medications continues to force leading cancer centers around the U.S. to seek work-around strategies to treat patients and a
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Physics Today @physicstoday.aip.org · 10/09/2026
With less than one month to go in the federal fiscal year, NSF has awarded 31% fewer grants in its math and physical sciences directorate than the average for 2000–24. physicstoday.aip.org/news/the-shrin…
physicstoday.aip.org
The shrinking NSF support for the physical sciences
The agency has awarded fewer grants in the physical sciences this year than most years in its history.
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Reposted by Quinn Sievers
Caroline Bartman @cbartman.bsky.social · 10/09/2026
Excited to share the first published paper from my lab! Postdoc Helen Jordan led this study on 1) how metabolites change differently in inflammation in tissues versus in cells in a dish and 2) the role of one of the most-increased metabolites, soluble sialic acid www.jbc.org/article/S002...
jbc.org
Metabolomics of in vivo inflammation identifies soluble sialic acid as a conserved myeloid-cell metabolite
During an immune response, metabolism changes dramatically. Metabolites are oxidized to power immune cell functions, serve as building blocks for proliferation, and act as effectors to regulate pathog...
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Reposted by Quinn Sievers
Addgene @addgene.bsky.social · 08/09/2026
DNA prep shouldn't be the hardest part of your experiment. Something's changing in our catalog on September 15. We can't wait to show you what's next. #Plasmids #Transfection
Dark blue Addgene teaser graphic with white text reading, "New service coming soon" and the date "09.15.2026," alongside the Addgene logo.
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Reposted by Quinn Sievers
Fred Hutch @fredhutch.org · 07/09/2026
Fred Hutch and UW are recruiting a physician-scientist faculty member in Radiation Oncology. Help advance translational cancer research while delivering exceptional patient care and training the next generation of clinicians. Apply: apply.interfolio.com/192383
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UW–Madison School of Pharmacy @uwmadpharmacy.bsky.social · 31/08/2026
🚨 New "McR-TACs" by Associate Professor Quanyin Hu & collabs recycle. The degrader pulls its target protein into the cell, then releases it & exits via ER–Golgi transcytosis for another round. Durable PD-L1 & MIF degradation slowed tumors in triple-negative breast #cancer model.
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Reposted by Quinn Sievers
Max Kozlov @maxkozlov.bsky.social · 04/09/2026
Under pressure, the DOD just released the text of its secret 10-year agreement with the NIH. Here are the biggest revelations from the document 🧵
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Inigo Martincorena @imartincorena.bsky.social · 03/09/2026
Big paper alert! This project has been years in the making. A comprehensive description of somatic mutation rates and signatures across 53 tissues or cell types using NanoSeq. A large collective effort led by Mimy Pham, Mike Stratton and @r-rahbari.bsky.social. www.biorxiv.org/content/10.6...
biorxiv.org
A comprehensive atlas of somatic mutation rates and mutational signatures in normal human cells
Over the course of a lifetime, somatic mutations accrue in normal human cells, causing variation in cell phenotype and engendering somatic evolution with outcomes ranging from the adaptive immune syst...
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Reposted by Quinn Sievers
Steven Banik @stevenbanik.bsky.social · 01/09/2026
Excited our ratiometric transcriptional activation (RTA) work led by postdoc Dr. Melissa Gray is out online today in Cell @cp-cell.bsky.social! Measurements determine what we can discover in biology; we use RTA to turn protein abundance changes into amplified signals in live cells.
cell.com
Ratiometric transcriptional activation by protein degradation
By tethering a protein of interest to anti-CRISPR, protein degradation is transformed into amplified and programmable transcriptional outputs via Cas-based transcription factors, with sensitivity to p...
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Reposted by Quinn Sievers
In Preparation @inprep.bsky.social · 02/09/2026
inpreparation.substack.com
Anthropic Expands AI For Science Program In Hopes Someone Will Love It
SAN FRANCISCO, CA—Anthropic announced an expansion of their new AI for Science initiative Thursday in the hope that helping cure diseases might make people feel warmly toward the artificial…
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Reposted by Quinn Sievers
Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · 31/08/2026
What if a blood test could detect lymphoma more precisely than an imaging scan? MSK's Dr. Mark Roschewski is studying how blood-based tests for circulating tumor DNA may help guide treatment decisions and determine whether cancer remains after therapy. Learn more: bit.ly/4zZOwlx
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Reposted by Quinn Sievers
Ardem Patapoutian @ardemp.bskyverified.social · 31/08/2026
NIH's Aug 2026 proposal would scrap exact scores and percentiles for three broad bins (top = top 25%). With funding rates at 5% or lower, too much then rides on administrative discretion. It devalues peer review and is a deterrent to engage. Tell NIH before Oct 13. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-088: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH
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Quinn Sievers @quinnsievers.bsky.social · 30/08/2026
This was a fantastic discussion!
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Reposted by Quinn Sievers
Ann Mullally @mullallylab.bsky.social · 28/08/2026
Check out my conversation w/ @rosslevinemd.bsky.social Whether you’re a student, resident/fellow, hematologist/oncologist, cancer biologist, drug discoverer or patient, this #TheFutureofMedicine podcast is for you! @stanforddeptmed.bsky.social @mskcancercenter.bsky.social youtu.be/KNB27ZRqABI?...
youtu.be
Ross Levine on Blood Cancer, Cancer Genetics, and New Therapies
YouTube video by Stanford Department of Medicine
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Quinn Sievers @quinnsievers.bsky.social · 28/08/2026
www.nytimes.com/2026/08/27/s...
nytimes.com
Some Scientists Have ‘Magic Hands’ in the Lab. This A.I. Is Learning Why.
Even the most adept researchers may not know exactly what they do to get successful results. An A.I. model is trying to figure it out by watching every move.
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Reposted by Quinn Sievers
anil oza @aniloza.bsky.social · 25/08/2026
OMB's proposal to remake federal grantmaking was flooded with comments Now, they are withdrawing some from the public record — including some that point out Russell Vought's connection to the federally funded research that led to Trikafta www.statnews.com/2026/08/25/r...
statnews.com
Comments on OMB research rule mysteriously removed from federal website
Some comments on a proposed OMB research rule have been mysteriously removed from a public-facing government webpage.
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In Preparation @inprep.bsky.social · 27/08/2026
inpreparation.substack.com
"We're Like A Family Here," Says PI Who Would Fire His Family
BOSTON, MA—Describing the close-knit culture of his laboratory, Boston University professor Dr.
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Reposted by Quinn Sievers
Stephan Hacker @stephanhacker2.bsky.social · 22/08/2026
What are the hot topics in Chemical Biology? If you want to learn about the exciting perspective of students of Johannes Morstein's (@morstein.bsky.social) Ch/Bi145 course at @caltech.edu, you can now do so in their ChemBioChem review. doi.org/10.1002/cbic... (1/13) @chemistryeurope.bsky.social
doi.org
Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech
This student-authored review highlights notable advances in synthetically enabled chemical biology from 2025, spanning bioconjugation and bioorthogonal chemistry, visualization and sensing, precision...
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Ardem Patapoutian @ardemp.bskyverified.social · 19/08/2026
Discover all the wonderful ways you can join the @hhmi-science.bsky.social, with opportunities ranging from undergraduate students to senior investigators. There will be no upper limit on career-stage eligibility for the Investigator program!
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Michael Socolow @michaelsocolow.bsky.social · 18/08/2026
Today is August 18, 2026. 20 years ago today, on August 18, 2006, "Snakes on a Plane" was unleashed on the American movie-going audience, in the midst of "That Campy Summer." A reminiscence, in The Lint Trap. linttrapofhistory.substack.com/p/that-campy...
linttrapofhistory.substack.com
That Campy Summer: “Snakes on a Plane,” and the Lost World of 2006
Twenty years ago, the Camp aesthetic and mass culture still existed in parallel while being mutually interactive. Today, when the President dances to "Y.M.C.A." something subversive's been co-opted.
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NEJM.org @nejm.org · 19/08/2026
In a child with advanced nephroblastoma, T-cell therapy targeting preferentially expressed antigen in melanoma led to a 69% tumor reduction, with molecular, metabolic, and histologic evidence of complete remission at 200 days. Full case details: nej.md/3U8jVl2
A graph showing the change in the diameter of respective target lesions measured according to Response Evaluation Criteria in Solid Tumors, version 1.1, which documents pseudoprogression in liver metastases.
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Nature Biotechnology @natbiotech.nature.com · 19/08/2026
A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability www.nature.com/articles/s41...
nature.com
A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability - Nature Biotechnology
A prospective, blinded competition is conducted for artificial-intelligence-generated and optimized antibody discovery.
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NEJM.org @nejm.org · 17/08/2026
With one week to go before your board exam, should you prioritize late-night cram sessions? Good sleep? Exercise? Which factors are associated with a higher chance of passing? This Stats, STAT! animated video from NEJM Evidence uses logistic regression to find out: youtu.be/SKj22NkaYfc
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STAT @statnews.com · 17/08/2026
STAT's @brittanytrang.com is headed to Epic headquarters, where it's welcoming thousands of customers for its annual meeting amid executive departures and antitrust interest from the FTC. Reach out to her if you're there.
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Julia Carnevale @juliacarnevale.bsky.social · 17/08/2026
Another major milestone for my lab - our second paper is out today in Nature Biotechnology! Co-led by Pascal Devant & Hyuncheol Jung, with @marsonlab.bsky.social: www.nature.com/articles/s41...
nature.com
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells - Nature Biotechnology
Primary human myeloid cells are efficiently edited using virus-like particles.
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Gladstone Institutes @gladstoneinst.bsky.social · 17/08/2026
Scientists at Gladstone and UCSF developed a method to genetically edit myeloid cells, immune cells that act as the body’s first responders. @ucsanfrancisco.bsky.social @juliacarnevale.bsky.social @marsonlab.bsky.social
gladstone.org
New Toolkit Turns Macrophages Into Better Cancer Fighters
Gladstone and UCSF scientists developed a method to genetically edit myeloid cells, immune cells that act as the body's first responders.
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Nature Biotechnology @natbiotech.nature.com · 17/08/2026
From cabozantinib to zanzalintinib: obvious chemical modifications as a new frontier in product hopping www.nature.com/articles/s41...
nature.com
From cabozantinib to zanzalintinib: obvious chemical modifications as a new frontier in product hopping - Nature Biotechnology
Obvious chemical substitutions could be used to generate powerful new composition-of-matter patents, highlighting the need for patent and antitrust policy reforms that better separate strategic pursui...
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Thomä lab @labthoma.bsky.social · 13/08/2026
Congrats to Pius, Shuhao, and the team! Check out our latest publication: Molecular glue degraders (MGDs) like lenalidomide have transformed multiple myeloma treatment by inducing degradation of non-native substrates via the CRL4CRBN E3 ligase—but which proteins can they actually reach?
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Andrew Hardaway @andrewhardaway.bsky.social · 15/08/2026
Successfully didn't let the latest Friday evening notice dump ruin my friday with friends. But now its time to break down RFI NOT-OD-26-088. A thread.
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Fred Hutch @fredhutch.org · 15/08/2026
🔬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in the Basic Sciences Division @basicsci.fredhutch.org. Join a world-class research community in Seattle and help advance discoveries in fundamental biology. Apply: apply.interfolio.com/190640
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elizabethginexi.bsky.social @elizabethginexi.bsky.social · 14/08/2026
‼️NIH is proposing to change NIH Peer Review outcomes. Instead of impact scores they propose 3 categories: "Most competitive" "Competitive", or "Not discussed" This RFI link will accept your comments/feedback on this proposal until 10/13/26. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-088: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH
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Gladstone Institutes @gladstoneinst.bsky.social · 14/08/2026
🚨 NEW PUBLICATION 🚨 "In vivo genome-wide CRISPR screens of human T cells in solid tumours" in @nature.com @marsonlab.bsky.social @ucsanfrancisco.bsky.social
nature.com
In vivo genome-wide CRISPR screens of human T cells in solid tumours - Nature
An in vivo model that is able to recover human T cells from solid tumours can identify targets to help improve CAR T cell antitumour activity.
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Nature Biotechnology @natbiotech.nature.com · 13/08/2026
Research Highlight: Killing resistant tumors with a click www.nature.com/articles/s41...
nature.com
Killing resistant tumors with a click - Nature Biotechnology
Nature Biotechnology - Killing resistant tumors with a click
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Bryan Dickinson @chembiobryan.bsky.social · 11/08/2026
Big faculty search in chemical biology, campus-wide, at University of Chicago! Come be my colleague! This is a special place! apply.interfolio.com/190752
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Addgene @addgene.bsky.social · 11/08/2026
It’s prime time! 😎 New AI-redesigned PE8, from the David Liu lab at Broad Institute, inspired us to update our prime editing post — and boy has this field been busy! Check it out:
twp.ai
blog.addgene.org
Prime Editing: Adding Precision and Flexibility to CRISPR Editing
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Ajay Major, MD, MBA @majorajay.bsky.social · 10/08/2026
Mosun/pola in R/R MCL post BTKi @BloodPortfolio - 42 pts, 67% high Ki67, 48% TP53mut, 26% prior CAR - ORR 88% (CR 79%), post-CAR ORR 91%, TP53mut ORR 100% - mPFS 18.6 mos, mOS 20.7 mos - CRS 43% (all G1-2), ICANS 7% (all G1-2) - 5 (12%) G5 infection-related AEs (3 COVID, 1 WNV, 1 PNA) #oncsky 1/2
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