The RNA-binding protein ZFP36L2 mediates stress-adaptive plasticity in intestinal regeneration and colorectal cancer metastasis.

The authors show that aberrant epithelial GREM1 expression remodels intestinal stroma to form ectopic stem cell niches in mice. Anti-GREM1 reversed these changes, highlighting a potential strategy for...

This Review focuses on epithelial–mesenchymal crosstalk and how these interactions shape development, health and disease in the intestinal mucosa. The dynamic nature of this ecosystem is highlighted, ...

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibronectin deposition and support metastatic niche ...

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MRC National Mouse Genetics Network (NMGN) members from the Cancer Cluster and the new Data Platform initiative are at the centre of a new project announced on the 31st of […]

Cancer-associated fibroblasts and immune cells are known to interact within the tumor microenvironment and influence each other to impact on tumor progression. Here, Kay et al. discuss how they can al...

View details and apply for this Data Scientist vacancy in Sutton. Salary Range: Commencement on the salary range is subject to comparable skills and experience. Future progression is based ...

NAC regulates the ribosome localization, metabolic profile, and fate of intestinal stem cells.

Programmable Enrichment via RNA FlowFISH by sequencing (PERFF-seq) isolates rare cells based on RNA marker transcripts for single-cell RNA sequencing profiling of complex tissues, with applicability t...

The generation of spatial data in biology has been transformed by multiplex imaging and spatial-omics technologies, such as single cell spatial transcriptomics. These approaches permit a detailed mapp...

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The generation of spatial data in biology has been transformed by multiplex imaging and spatial-omics technologies, such as single cell spatial transcriptomics. These approaches permit detailed mappin...