The immunosuppressive tumour microenvironment (TME) reduces immune response effectiveness in stromal-rich tumours, including CMS4 colorectal cancer (CRC). Mesenchymal stromal cells (MSCs), precursors ...

Directly contact your elected officials about the importance of cancer research, the need for continued funding and the latest lifesaving breakthroughs. In the United States, you can do so by sending ...

University of Galway’s Dr Aideen Ryan is looking at mechanisms in supportive tissue cells with the aim of enhancing the body’s immune response to cancers.

University of Galway’s Dr Aideen Ryan is looking at mechanisms in supportive tissue cells with the aim of enhancing the body’s immune response to cancers.

Alt: a large rock is rolling down the side of a rocky hill and being pushed back up by Sisyphus

YouTube video by CUNY Graduate Center

Scientific Reports - Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data

Immunotherapy is the brightest new weapon in fight against cancer. Thank Dr. Steven Rosenberg, who 40 years ago successfully used it to save a life.

Han et al. identify crosstalk between CAFs and pancreatic cancer cells under hypoxia and nutrient scarcity. Lysophosphatidylcholines (LPCs), as the key mediators, can be utilized for phosphatidylcholi...

Prof Sharon Glynn is a Professor in Pathology at the University of Galway working with Cúram, the Research Ireland centre for medical devices. In this interview she talks about advancements in the und...

Cancer cells often evade the host immune system, challenging the effectiveness of immunotherapy. In this comprehensive review, Galassi et al. summarize key mechanisms of immune evasion within the “thr...

The prodrug gliocidin effectively kills glioblastoma cells by targeting de novo purine synthesis, improving survival in mouse models.

Mechanisms of prostaglandin E2 (PGE2)-mediated immunosuppression in the tumor microenvironment (TME) have been previously reported. Here, the authors profile PGE2 functions in human cancer, suggesting...