iiinova — where your digital self keeps evolving

Reposted by Leon Lotter

Ian Shih @shihyyi.bsky.social · 19/05/2026

Using fMRI data from 20 mouse models and large human cohorts, a recent study in @natneuro.nature.com identifies two dominant dysconnectivity patterns linked to distinct molecular signatures in #autism. See our summary and perspectives on the latest work from @gozziale.bsky.social lab: rdcu.be/fiSOL

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Leon Lotter @leondlotter.de · 07/05/2026

My most recent and biggest work so far is finally out as a preprint! 🧠🧵 *Linking human brain functional connectivity to underlying neurotransmission* doi.org/10.64898/202... 1/n TL;DR below ↓ #neuroskyence #neuroimaging #MedSky #PsySciSky

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Leon Lotter @leondlotter.de · 07/05/2026

Catching up on my paper threads 🧵 Here is a perspective from this year, lead-authored by my supervisor, @juergendukart.bsky.social The many-to-many problem of endophenotypes in psychiatry - a biological perspective doi.org/10.1038/s413... #neuroskyence #neuroimaging #MedSky #PsychSciSky 1/n

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Leon Lotter @leondlotter.de · 06/05/2026

*Rescuing Twitter Threads* series 2021: This was my first fist-author and MD thesis paper! *Recovery-Associated Resting-State Activity and Connectivity Alterations in Anorexia Nervosa* doi.org/10.1016/j.bp... PDF: leondlotter.de/doc/2021_ANR... 1/n #neuroskyence #neuroimaging #AcademicSky #SciSky

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Leon Lotter @leondlotter.de · 06/05/2026

*Rescuing Twitter Threads* series 2023: *Revealing the neurobiology underlying interpersonal neural synchronization with multimodal data fusion* doi.org/10.1016/j.ne... 1/n #neuroskyence #neuroimaging #AcademicSky #SciSky

Summary of results and hypotheses. Abbreviations: INS = interpersonal neural synchronization, DAN/VAN = dorsal/ventral attention network, DMN = default mode network, ToM = theory of mind network, TPJ = temporoparietal junction, IFG = inferior frontal gyrus, dm/vmPFC = dorsomedial/ventromedial prefrontal cortex, AI = anterior insula, PMC = premotor cortex, IPL = inferior parietal lobule, OFC = orbitofrontal cortex, VS = ventral striatum, OXT = oxytocin, E/I = excitation/inhibition balance.

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Leon Lotter @leondlotter.de · 06/05/2026

*Rescuing Twitter threads* series 2024: *Regional patterns of human cortex development correlate with underlying neurobiology* doi.org/10.1038/s414... 1/n #neuroskyence #neuroimaging #AcademicSky #SciSky

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Leon Lotter @leondlotter.de · 06/05/2026

Hello Bluesky! Below this post, you will find all my very interesting "new paper" threads. 🤓 Note that some of these are much older than the timestamp because I rescued them from Twitter to make them accessible for everyone.

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Reposted by Leon Lotter

Juergen Dukart @juergendukart.bsky.social · 10/02/2026

Despite decades of research there are still no reliable biomarkers for any of the major psychiatric diagnoses. In this now published perspective in Molecular Psychiatry we consolidate evidence from genetics, exposome and neuroimaging research on the potential reasons underlying these failures.

nature.com

The many-to-many problem of endophenotypes in psychiatry - a biological perspective - Molecular Psychiatry

Molecular Psychiatry - The many-to-many problem of endophenotypes in psychiatry - a biological perspective

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Reposted by Leon Lotter

Benjamin Kay @benjaminkay.bsky.social · 30/09/2025

Ever wondered if your interesting brain-behavior correlation was over- or under-estimated due to head motion, but were afraid to ask? We’ve created a motion impact score for detecting spurious brain-behavior associations, now available in Nature Communications! doi.org/10.1038/s414...

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Reposted by Leon Lotter

Ole Goltermann @olegolt.bsky.social · 22/07/2025

Serious concerns about a new cortical biomarker for pain sensitivity jamanetwork.com/journals/jam... We (with @tspisak.bsky.social, @christianbuchel.bsky.social) published a commentary on Chowdhury, Bi et al. (2025, JAMA Neurology) raising serious concerns about their reported results. 👇 1/13

jamanetwork.com

Concern About Predictive Performance of a Pain Sensitivity Biomarker

To the Editor Chowdhury et al1 evaluated a biomarker for pain sensitivity, combining peak alpha frequency and corticomotor excitability. The authors report outstanding performance (validation set area...

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Reposted by Leon Lotter

Thomas Yeo @bttyeo.bsky.social · 17/07/2025

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

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Reposted by Leon Lotter

Deniz Yilmaz @deniz-yilmaz.bsky.social · 02/07/2025

After some time since completing my Master’s thesis, I’m excited to share that our work has now been published! It’s rewarding to see the project come full circle and contribute to the field alongside a fantastic team. You can read the full article here: doi.org/10.1093/brai... Published in Brain 🧠

doi.org

N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference

Perception combines external sensory signals with internal predictions that reflect prior knowledge about the world. Weilnhammer et al. show that the NMDAR

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Leon Lotter @leondlotter.de · 05/06/2025

Amazing new paper on individual development of E/I balance during adolescence, first-authored by @amnsbr.bsky.social! Read @ Science Advances: www.science.org/doi/10.1126/... Bonus: Amin developed a tool to run biophysical network modelling on GPUs – because why shouldn't he? cubnm.readthedocs.io

science.org

Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling

Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.

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Reposted by Leon Lotter

Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · 30/05/2025

🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘 www.biorxiv.org/content/10.1... Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇

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Reposted by Leon Lotter

Lucina Uddin @lucinauddin.bsky.social · 28/05/2025

When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...

nature.com

The history and future of resting-state functional magnetic resonance imaging - Nature

This Review provides an overview of the history of resting-state functional MRI research, which has helped to reveal the spatiotemporal organization of the brain, and discusses how it can contribute f...

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Reposted by Leon Lotter

ARC-COGITATE @arc-cogitate.bsky.social · 27/05/2025

🏁 Big news from #Cogitate!🏁 We’re proud to deliver the first part of our promised open multimodal dataset: iEEG data from 38 patients across 3 centers, collected under a unified protocol. 📄 Paper: doi.org/10.1038/s415... 📀 Data: www.arc-cogitate.com/data-release 💻 Code: github.com/Cogitate-con...

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Reposted by Leon Lotter

Taylor Bolt @tsbolt.bsky.social · 07/05/2025

First post on an exciting new manuscript online today @natneuro.nature.com - in collab with @lucinauddin.bsky.social and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠 ... www.nature.com/articles/s41... Read here: rdcu.be/ek01F

rdcu.be

Autonomic physiological coupling of the global fMRI signal

Nature Neuroscience - The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.

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Reposted by Leon Lotter

Loïc Labache @loiclabache.cpesr.fr · 12/04/2025

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization 🔗 doi.org/10.1101/2025... 🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇 #neuroskyence

doi.org

The molecular and cellular underpinnings of human brain lateralization

Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...

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Reposted by Leon Lotter

IGOR DGPs @igor-dgps.bsky.social · 12/04/2025

🧠🌱 New preprint from the IGOR Sustainability project! "There is no research on a dead planet" How can we balance neuroscience, open science, and climate responsibility? 📄 Read our position paper on OSF: osf.io/preprints/osf/rju75_v1

osf.io

OSF

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Reposted by Leon Lotter

Jeremy Berg @jeremymberg.bsky.social · 21/01/2025

Bluetorial-A dream and a bit of a nightmare Serving as Editor-in-Chief at Science was fascinating. I greatly enjoyed working with talented and committed editorial, news, graphics, and production staff. But the inside look into scientific publishing and AAAS was also deeply disillusioning.

media.tenor.com

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

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Reposted by Leon Lotter

Chirag Mehra @chirag-mehra.bsky.social · 05/01/2025

🎉 New Year, New Preprint. Happy to share the first preprint from my #PhD! 🧠 🤔 TL;DR: Our findings are relevant to anyone using EEG / MEG functional connectivity analyses. They affect the choice of method when analysing your data. Check it out and tell me your thoughts: shorturl.at/TD3wc 1/6

biorxiv.org

Zero-phase-delay connectivity increases the reliability, concordance with structure, and prognostic ability of functional connectivity metrics

Zero-phase-delay synchrony between the activity of distant neural populations has been robustly observed. Nevertheless, contemporary electroencephalography and magnetencephalography functional connect...

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Reposted by Leon Lotter

Kevin Mitchell @wiringthebrain.bsky.social · 03/01/2025

A New Year's rant, for 2025 😊:

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Reposted by Leon Lotter

Bratislav Misic @misicbata.bsky.social · 20/12/2024

The effect of spherical projections on spin tests for brain maps | biorxiv.org/content/10.1... Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️

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Reposted by Leon Lotter

Simon Eickhoff @sbe.bsky.social · 13/12/2024

The limiting factor for MRI based prediction of behavioral traits may be neither the imaging nor the pipeline or learning algorith but rather the reliability of the target phenotypes Thought provoking work my Martin Gell et al: www.nature.com/articles/s41...

nature.com

How measurement noise limits the accuracy of brain-behaviour predictions - Nature Communications

Our ability to identify associations between behaviour and brain imaging is important for uncovering markers of cognition and disease. Here, the authors illustrate the importance of the reliability of...

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Reposted by Leon Lotter

Bluesky @bsky.app · 03/12/2024

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

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Reposted by Leon Lotter

Ashley Nielsen @ashley-n-nielsen.bsky.social · 02/12/2024

New paper out today in PNAS 🎉 demonstrating: 1) an association between social disadvantage & child brain function can be observed as early as birth 2) these alterations are brain-wide, but most pronounced in functional networks & subcortex later linked to childhood adversity doi.org/10.1073/pnas...

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Reposted by Leon Lotter

Mike Frank @mcxfrank.bsky.social · 03/12/2024

Three ManyBabies projects - big collaborative replications of infancy phenomena - wrapped up this year. The first paper came out this fall. I thought I'd take this chance to comment on what I make of the non-replication result. 🧵 bsky.app/profile/laur...

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Reposted by Leon Lotter

Boris Bernhardt @borismontreal.bsky.social · 03/12/2024

🍾 Now in press @elife.bsky.social Multimodal correlates of childhood psychopathology co-led by @jroyer.bsky.social , Valeria Kebets, @bttyeo.bsky.social & our many fantastic co-authors 🙏 based on the ABCD dataset 👉 elifesciences.org/articles/87992

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Reposted by Leon Lotter

Leah Banellis @leahbanellis.bsky.social · 28/10/2024

What happens when our stream of consciousness turns inward, towards the body? Our new fMRI study of 536 individuals finds that 'body-wandering' is associated with distinct patterns of brain connectivity, physiology, affect, and mental health: www.biorxiv.org/content/10.1...

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Reposted by Leon Lotter

Sharna Jamadar @sharnajamadar.bsky.social · 29/11/2024

Very pleased to share our latest preprint by superstar Hamish Deery! We found some intriguing sex and age differences in cerebral blood flow & metabolism 🤔 🧠🤨using #simultaneousPETMR. #neuroskyence #MonashPsych #MonashBiomedicalImaging @acnsau.bsky.social

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Reposted by Leon Lotter

Russ Poldrack @russpoldrack.org · 27/11/2024

Welcome @nilearn.bsky.social to Bluesky! Nilearn is an amazing package for neuroimaging analysis in Python - certainly one of the most heavily used packages in our lab.

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Reposted by Leon Lotter

PubPeer @pubpeer.com · 25/11/2024

PubPeer has received the 2024 Einstein Foundation Award. This recognition celebrates the contributions of our community to scientific discourse. award.einsteinfoundation.de/award-winner... This award provides a financial boost that we’re reinvesting back into the platform and its users. See below:

award.einsteinfoundation.de

PubPeer – Einstein Foundation Award

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Reposted by Leon Lotter

Nico Schuck @nicoschuck.bsky.social · 24/11/2024

Looking for a PhD in Cognitive Science, Cognitive Neuroscience or related in Germany? One week left to apply for the Max Planck School of Cognition: cognition.maxplanckschools.org/en/application #PsychSciSky #compneurosky #neuroskyence #NeuroAI #Neuroimaging

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Reposted by Leon Lotter

Markus Eichhorn @markuseichhorn.bsky.social · 22/11/2024

Who should you nominate as reviewers for your manuscript? After a long chat with a post-grad it appears that there's a lot of misguided advice out there. Thread 👇

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Reposted by Leon Lotter

Gabriel Rodríguez Lemus, Jr. @grodriguezlemus.bsky.social · 14/11/2024

Be in community with other doctoral students journeying through academia. Please reply to this post if you want to be added!! #DocStudents go.bsky.app/QTfevfQ

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Reposted by Leon Lotter

Luis Colon-Perez, PhD @luismcolonperez.bsky.social · 24/11/2024

Hello Bluesky! Looking to connect with #neuroimaging #compneurosky #neuroskyence #neuroscience #psych peers. I will be sharing work on addiction and aging using MRI and behavior but also want to learn from the neuro community here on mental health and neurobiology.

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Reposted by Leon Lotter

Alex Wiesman @alexwiesman.bsky.social · 23/11/2024

New pre-print! 🎉 www.medrxiv.org/content/10.1... We use a MEG with a PLS-neuromaps "search" of off-target cortical effects of dopamine therapies in patients with #Parkinson's disease A strong beta-rhythmic activation of dopamine-rich cortices in response to medication ▶️ worse clinical response

A scientific figure with two panels. On the left, a horizontal bar chart with patients 1-17 numbered on the y-axis, and the strength of dopamine alignment (i.e., pls weights) on the x-axis, which indicates the amount of cortical dopamine-system response to dopamine replacement therapies. The bars are sorted and colored with the strongest alignment on top and lowest alignment on bottom. Arrows extend from the top and bottom bars to brain maps showing strong and weak beta-frequency rhythmic dopamine responses, respectively, in inferior frontal and superior temporal cortices. On the right, a scatterplot shows a positive linear relationship between dopamine alignment (on the x-axis) and change in motor symptom response (on the y-axis, with higher/less-negative values indicating less symptom improvement). Statistics overlaid on the scatterplot indicate a correlation coefficient (r) of .64 and a p-value of .007.

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PennLINC @pennlinc.bsky.social · 22/11/2024

We're excited to release new versions of our BIDS-Apps for processing and analyzing #dmri data, QSIPrep and QSIRecon! Our team has been working hard to prepare these pipelines to process infant data and bring them in line with the @nipreps.bsky.social ecosystem. #neuroimaging #nipreps #bids 1/10

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Reposted by Leon Lotter

Carl T. Bergstrom @carlbergstrom.com · 22/11/2024

I feel like John Beatty was on to something really good with opencheck.is. I'd love to see this reinvigorated and adapted for Bluesky.

opencheck.is

OpenCheck

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Reposted by Leon Lotter

Julian Koenig @koeniglab.bsky.social · 21/11/2024

Getting this started. Let me know who I missed! go.bsky.app/815Mrzs

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Sergiu P. Pasca @sergiuppasca.bsky.social · 21/11/2024

Latest paper in Nature this week: an atlas integrating 36 single-cell datasets spanning 26 protocols for making neural #organoids Effort led by B. Treutlein, @fabiantheis.bsky.social and @graycamplab.bsky.social

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