Some individuals exhibit metabolically healthy obesity, characterized by the expansion of white adipose tissue (WAT) without associated complications.…

A new study on acceleration of vascular aging adds to the body of evidence

Brown adipose tissue hosts a distinct population of Treg cells that preserves thermogenesis by controlling local interferon-γ production.

Results reveal that weight loss has significant effects on cellular processes that are known to affect metabolic health and longevity.

Mammals maintain body heat by adaptive energy expenditure through different organ specific mechanisms. The glycerolipid/free fatty acid cycle (glycerolipid cycle), encompassing triglyceride lipolysis ...

Nature Communications - Thermogenesis by brown adipose tissue has long been thought to be solely controlled by uncoupling protein 1 (UCP1). Here, the authors show that energy expenditure in brown...

Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase kinases with the goal o...

Zhai, Yang et al. report a central role for AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy s...