Reposted by Hooman HefziNathan Lewis @natelewis3.bsky.social · 03/02/2025Took me a while to get the new uga address, but my lab website is finally live. lewislab.uga.edu 162
Hooman Hefzi @hefzi-lab.bsky.social · 20/01/2025After ~8 years, happy to share work done w/ @natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social! www.nature.com/articles/s42... #science #biotech #cancermetabolism Thread below:nature.comMultiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells - Nature MetabolismHefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase kinases with the goal o... 1178
