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Babak Razani, MD, PhD Laboratory

@razanilab.bsky.social
40 followers 30 following 12 posts

The Razani lab (www.razani.org) @ Center for Immunometabolism (cim.pitt.edu) and Vascular Medicine Institute (vmi.pitt.edu), University of Pittsburgh studies macrophages, autophagy-lysosomes, & nutrient sensing/signaling in metabolic disease

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Babak Razani, MD, PhD Laboratory @razanilab.bsky.social · 05/02/2026
New year resolution to post more! Proud of @yushengyeh & @RazaniLab members for their ATVB review this month comparing/contrasting newly discovered #adipocyte #lipolysis via #lysosome #LIPA vs. known cytoplasm #ATGL in #cardiometabolic #CVD 💪 www.ahajournals.org/doi/10.1161/...
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Babak Razani, MD, PhD Laboratory @razanilab.bsky.social · 25/06/2025
Happy to announce new work by Postdoc Fellow Yu-Sheng Yeh & @razanilab.bsky.social showing natural sugar #trehalose (known #autophagy #TFEB inducer) improves #obesity #metabolism. Caveat: it is ineffective by oral route & KO of gut enzyme #trehalase doesn't help. www.frontiersin.org/journals/nut...
frontiersin.org
Frontiers | Assessing the efficacy of the natural disaccharide trehalose in ameliorating diet-induced obesity and metabolic dysfunction
Trehalose is a naturally occurring disaccharide with versatile commercial applications and health benefits, including promise as a therapeutic for obesity an...
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Babak Razani, MD, PhD Laboratory @razanilab.bsky.social · 26/04/2025
Great showing by @razanilab.bsky.social at #VascularDiscovery25 in Baltimore the past 3 days. Kudos to efforts of Dr. Kathleen Martin, the entire organizing committee, & @americanheart.bsky.social for the excellent programming & opportunity to present our work. See you all next year in Bellevue, WA!
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Reposted by Babak Razani, MD, PhD Laboratory
Journal of Clinical Investigation @jci.org · 31/03/2025
Spilling the skinny on fat cells! @razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO
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Reposted by Babak Razani, MD, PhD Laboratory
The American Society for Clinical Investigation @the-asci.org · 28/03/2025
Spilling the skinny on fat cells! ASCI member @razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/Wc9YdnR
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Babak Razani, MD, PhD Laboratory @razanilab.bsky.social · 26/03/2025
Nice work in @cp-immunity.bsky.social by Cobo & Glass labs showing #macrophage crystalline/particle uptake universally induce #lysosome #transcription program via #AMPK #TFEB independent of #inflammation pathways. Thx for including @razanilab.bsky.social in the journey. www.cell.com/immunity/abs...
cell.com
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression
Particle exposure drives inflammation through unknown regulatory mechanisms. Cobo et al. identified a bifurcated transcriptional response in macrophages: an AMPK-TFEB/TFE3-DNMT3A/DOT1L axis controllin...
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Babak Razani, MD, PhD Laboratory @razanilab.bsky.social · 19/03/2025
Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year Razani lab effort in @jclinical-invest.bsky.social by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL) jci.org/articles/view/185340
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Babak Razani, MD, PhD Laboratory @razanilab.bsky.social · 14/03/2025
Announcing #Pittsburgh Metabolism Consortium. Joint venture by the Endocrinology Division, Center for Immunometabolism (CIM), Center for Mitochondrial Medicine (C3M), we aim to bring together the #metabolism community at the University of Pittsburgh. Spring seminar series start next week 🤩
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Babak Razani, MD, PhD Laboratory @razanilab.bsky.social · 12/03/2025
Fresh off the press data (for FY24) on the immense economic impact of #NIH #biomedical #science research. $2.56 goes into economy for every $1 grant funding. 💪 www.unitedformedicalresearch.org/annual-econo...
unitedformedicalresearch.org
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Babak Razani, MD, PhD Laboratory @razanilab.bsky.social · 27/02/2025
Excellent #immunometabolism concept presented by Garaude lab @univbordeaux.bsky.social in @nature.com. #macrophage #nutrient use of dead bacteria via #phagocysosis drives distinct #metabolism pathways. #mTOR rears its head of course. #efferocytosis should be up next! www.nature.com/articles/s41...
nature.com
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
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Babak Razani, MD, PhD Laboratory @razanilab.bsky.social · 19/02/2025
Is dietary #protein and #mTOR good for skeletal muscle health or not? At least for #sarcopenia in elderly it is paradoxically harmful and enhancing #BCAA catabolism is protective. Interesting work in @natureaging.bsky.social by lab of Prof. Tao Li @ Sichuan University. www.nature.com/articles/s43...
nature.com
Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target - Nature Aging
Using multi-omics analysis, Zuo, Zhao, Wu, Wang, Wang and colleagues report disrupted branched-chain amino acid (BCAA) catabolism in skeletal muscle samples from patients with sarcopenia. In mouse mod...
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Babak Razani, MD, PhD Laboratory @razanilab.bsky.social · 17/02/2025
Hello everyone, greetings from members of the Razani laboratory. First post for us here. We heard many #physicians, #scientists, and #entrepreneurs also started a presence here and so we wanted to join the fun and learn from you all!
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