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Nathan Lewis

@natelewis3.bsky.social
610 followers 292 following 31 posts

GRA Eminent Scholar and Professor at University of Georgia. Into Systems Biology, genome editing, cell-cell interactions, glycobiology, metabolism, biologics, and lots of other cool science stuff. lewis.uga.edu

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Nathan Lewis @natelewis3.bsky.social · 04/09/2026
Hooman Hefzi (DTU), a Prior student of mine, is running a really cool mammalin syn/sysbio lab now. He's hiring systems and structural bio postdoc now. efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
efzu.fa.em2.oraclecloud.com
Postdoc in in silico systems and structural biology of mammalian cell lines for biotherapeutic protein production - DTU Bioengineering
Ready to engineer the next generation of CHO cell lines? As a postdoctoral researcher, you’ll use a range of computational tools to design pathways, understand cellular responses, and guide subsequent...
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Nathan Lewis @natelewis3.bsky.social · 30/06/2026
It took several years, but @hmbaghdassarian.bsky.social got it working... genome scale models of human metabolism, transcription, translation, and protein secretion (ME+secretion model). Check out the preprint! www.biorxiv.org/content/10.6...
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Nathan Lewis @natelewis3.bsky.social · 30/06/2026
Our recent work mapping out the protein-protein interactions with IL-2 before and after T-cell stimulation. pubs.acs.org/doi/full/10....
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Nathan Lewis @natelewis3.bsky.social · 08/05/2026
Had fun annotating glycopeptides from DIA-MS glycoproteomics by looking at similar MS spectra, glycan biosynthetic pathways. Awesome collaboration with Alejandro Gomez Toledo and Johan Malmström from Lund Univ and James Sorrentino in my lab. #glycotime doi.org/10.1080/1942...
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Nathan Lewis @natelewis3.bsky.social · 17/04/2026
Why do some cells produce more protein than others? Jasmine Tat (UCSD & Amgen) conducted a detailed study into the single-cell transcriptome, while measuring mAb production in single cells too with SEC-seq. Check out the preprint! doi.org/10.64898/202...
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Nathan Lewis @natelewis3.bsky.social · 15/04/2026
Our team of ~50 researchers built a major update on the CHO genome-scale metabolic model. This includes 3D enzyme structures, and it helped us understand better how cells suppress glucose catabolism when the Warburg metabolism is suppressed. authors.elsevier.com/a/1mxeh8YyDf...
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Nathan Lewis @natelewis3.bsky.social · 11/03/2026
Congrats to Dr. Jasmine Tat, who proved that a great PhD thesis is possible while conducting her research while working in industry. 1 great paper in Cell Systems, and more innovative ones coming soon! If only I could have convinced her to obey the sign behind her. doi.org/10.1016/j.ce...
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Nathan Lewis @natelewis3.bsky.social · 26/02/2026
Check out our latest work on inferring metabolite-protein-mediated cell-cell communication. Led by @erickarmingol.bsky.social doi.org/10.1093/bioi...
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Reposted by Nathan Lewis
Denis Wirtz @deniswirtz.bsky.social · 14/12/2025
Download our large database of funding opportunities for early-career faculty and researchers Download it here: research.jhu.edu/rdt/funding-... 433 funding opportunities.
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Nathan Lewis @natelewis3.bsky.social · 10/12/2025
~1/3 of protein-coding genes are made in the secretory pathway. We curated >1000 of its machinery proteins, opening up new opportunities to engineer cells for drug production, to study cell-cell interactions, or modeling. @cp-cellsystems.bsky.social paper -> authors.elsevier.com/a/1mFMc8YyDf...
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Nathan Lewis @natelewis3.bsky.social · 03/12/2025
Congrats to Mina Wu for an excellent PhD defense on improving production of mAbs and vaccine proteins by studying protein-protein interactions in the production cells. See doi.org/10.1002/biot... and doi.org/10.1016/j.ym...
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Nathan Lewis @natelewis3.bsky.social · 22/11/2025
Got a great score for a vaccine proposal and yet fearful about if it will be funded. Maybe my next proposal will fare better? "Intersectional Bias, Woke Adjuvants, and Inclusive Nanoparticle Vaccines: Disinformation-Resilient Immunity in Trans-genic Mice and Women". Fundable?
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Nathan Lewis @natelewis3.bsky.social · 06/11/2025
Looking forward to this collaboration with Ginkgo www.genengnews.com/topics/biopr...
genengnews.com
Ginkgo Bioworks Awarded Project Agreement Through BARDA's BioMaP-Consortium
The goal of the project is to develop novel approaches that strengthen and reduce the costs of domestic mAb biomanufacturing to protect against and treat infection by filoviruses.
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Reposted by Nathan Lewis
Richard McElreath 🐈‍⬛ @rmcelreath.bsky.social · 23/10/2025
Monty Python understood p-hacking
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Nathan Lewis @natelewis3.bsky.social · 23/10/2025
😭
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Nathan Lewis @natelewis3.bsky.social · 18/10/2025
I love this visual of what I've been telling my kids / students, but I add that immediate answers rob our creativity too. I regularly ask myself "i can prompt this, but how important will my struggle be here?" Some tasks are perfect for AI. For others I choose to stimulate creativity & learning.
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Nathan Lewis @natelewis3.bsky.social · 14/10/2025
Why do some recomb proteins express better than others? After expressing >2000 proteins from the human secretome in CHO cells, we identified the protein features and host cell pathways linked to poor expression w/ @JohanRockberg lab. www.pnas.org/doi/abs/10.1...
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Nathan Lewis @natelewis3.bsky.social · 12/10/2025
Robert Francis Kennedy Junior
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BioF:GREAT @biof-great.bsky.social · 19/09/2025
The team at BioF:GREAT is always on the lookout for new protein design models that care about more than just the backbone! We are excited to try the new RFdiffusion3 (RFD3)! 🚀 New preprint from David Baker!🚀 🧪 #ProteinDesign #DeepLearning #ComputationalBiology www.biorxiv.org/content/10.1...
biorxiv.org
De novo Design of All-atom Biomolecular Interactions with RFdiffusion3
Deep learning has accelerated protein design, but most existing methods are restricted to generating protein backbone coordinates and often neglect interactions with other biomolecules. We present RFd...
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Nathan Lewis @natelewis3.bsky.social · 22/08/2025
Honored to have our recent work on mapping out the cell machinery regulating protein secretion highlighted at GEN www.genengnews.com/topics/biopr...
genengnews.com
Mapping Out the “Everything” of Protein Secretion
The invention of CRISPR and DNA sequencing has provided the necessary tools for rapidly engineering CHO cells along with a parts list.
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Nathan Lewis @natelewis3.bsky.social · 11/06/2025
Excitng collaboration in which we expressed a hepatitis c vaccine candidate in a panel of glycoengineered CHO cell lines. This allowed us to find a specific glycan structure that greatly improved immunogenecity, even for more distant strains #glycotime www.nature.com/articles/s41...
nature.com
Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity - npj Vaccines
npj Vaccines - Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity
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Nathan Lewis @natelewis3.bsky.social · 12/03/2025
While our first discovery of this occurred just weeks into the shutdown, it's great to see it off bioRxiv now. SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx. Great collab with Knight and Esko labs and many others #glycotime journals.asm.org/doi/10.1128/...
journals.asm.org
SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx | mBio
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019, can infect the gastrointestinal (GI) tract, and individuals who exhibit GI symptoms of...
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Nathan Lewis @natelewis3.bsky.social · 03/02/2025
Took me a while to get the new uga address, but my lab website is finally live. lewislab.uga.edu
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Nathan Lewis @natelewis3.bsky.social · 03/02/2025
With all of the US government science chaos going on, I'm curious if anyone knows which governments are seeing the great opportunity to recruit top labs and tech companies, to bolster their international presence, and to reverse the brain drain.
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Reposted by Nathan Lewis
GlyGen @glygen.bsky.social · 22/01/2025
🚨 Join us for the next GlyGen Webinar! 🗓 Feb 4, 2025 | 🕒 10 AM EST 🎙️ Speaker: Dr. Parastoo Azadi, CCRC, @universityofga.bsky.social 💡 Research, Collaboration, Service & Training at CCRC 📑 Details: wiki.glygen.org Also, don't miss our Jan webinar on Jan 28th! #glycotime
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Hooman Hefzi @hefzi-lab.bsky.social · 20/01/2025
After ~8 years, happy to share work done w/ @natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social! www.nature.com/articles/s42... #science #biotech #cancermetabolism Thread below:
nature.com
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells - Nature Metabolism
Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase kinases with the goal o...
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Nathan Lewis @natelewis3.bsky.social · 14/01/2025
I don't think that 101 years ago, Otto Warburg was aware how broadly relevant his discovery was. Check out our new paper out today in Nature Metabolism, wherein we engineered the Warburg effect out of mammalian cells to improve biologics production urldefense.com/v3/__https:/...
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Reposted by Nathan Lewis
Breeanna Urbanowicz @breeannau.bsky.social · 21/11/2024
Calling all glyco-enthusiasts!! We have an opening for a tenure-track faculty member at any rank in the Complex Carbohydrate Research Center (ccrc.uga.edu) in the areas of plant or microbial glycoscience. Come join our amazing team. #glycotime www.ugajobsearch.com/postings/400...
media.tenor.com
a cartoon of a pitcher with a spoon and a cup of sugar on a table
ALT: a cartoon of a pitcher with a spoon and a cup of sugar on a table
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Nathan Lewis @natelewis3.bsky.social · 20/01/2024
These past few years have seen a rapid expansion of cell-cell communication research. Check out our new review of the diverse methods leveraging single-cell and spatial omics: rdcu.be/dwkND
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