iiinova — where your digital self keeps evolving

Paola A. Marignani @pmarignani.bsky.social · 18h

Excited to share Episode 1 of my podcast Precision Science. Episodes will include scientists, patient advocates, healthcare professionals and more. Please that for my first episode, I interviewed the legend @jwoodgett.bsky.social Enjoy. youtube.com/watch?v=18Cf...

youtube.com

Precision Science - Ep 1 - Jim Woodgett

YouTube video by Precision Science

043

Paola A. Marignani @pmarignani.bsky.social · 07/09/2026

It's that time of the year when students apply to Professors for MSc, PhD or PDF mentorship. Great! Tip: Please remember to state in your email, where you received your undergraduate or graduate degrees, country & year. Be unique. Stand out.

021

Paola A. Marignani @pmarignani.bsky.social · 01/09/2026

Wow. Halifax is glowing tonight. Makes grant writing more enjoyable.

020

Reposted by Paola A. Marignani

American Society of Clinical Oncology @ascocancer.bsky.social · 14/08/2026

Attn. senior investigators! @conquercancer.bsky.social is accepting LOI’s for the Research Professorship in Ovarian Cancer. This award provides flexible funding to full professors dedicated to training the next generation of oncology leaders. LOIs due Sept. 23: bit.ly/45lusff

003

Paola A. Marignani @pmarignani.bsky.social · 28/06/2026

❤️🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦⚽

160

Paola A. Marignani @pmarignani.bsky.social · 25/06/2026

This level of energy input is not for the weak.

020

Reposted by Paola A. Marignani

LKB1 (STK11) @stk11.bsky.social · 22/06/2026

LKB1 loss suppresses estrogen, progesterone, and androgen signalling pathways, and that HLA-DRB5 is consistently downregulated across all STK11-mutated subtypes, suggesting an immune evasion component. A lot going on beyond the canonical AMPK-mTOR axis.

032

Paola A. Marignani @pmarignani.bsky.social · 22/06/2026

Preprint from marignanilab.com. LKB1 isn't just a tumour suppressor kinase with metabolic function; there's more😁. We used scRNAseq, CRISPR, patient tumours, METABRIC genomics & new mouse model to ask:what is the impact of losing LKB1 expression on breast cancer? www.biorxiv.org/content/10.6...

0132

Paola A. Marignani @pmarignani.bsky.social · 20/06/2026

.....perfect balance of protein, lipids and carbs! #bibimbap

020

Paola A. Marignani @pmarignani.bsky.social · 19/06/2026

🌤️☕👩🏻‍💻 Spatial distribution of the proteome in the human body and in cancers. The authors present a comprehensive human proteomic landscape, by profiling>13,000 proteins across 2,856 samples. Dataset spans 58 major tissue types, 251 specific tissue subtypes and 25 distinct carcinomas. t.co/GxtrlhTjMb

t.co

https://www.nature.com/articles/s41586-026-10660-y

010

Paola A. Marignani @pmarignani.bsky.social · 17/05/2026

....slowly easing back into climbing....very slow. Just getting here took some time. Goal: climb midway with controlled descent. Aim1. Put climbing shoes on Aim2. Chalk up hands Aim3. Just do it.

030

Paola A. Marignani @pmarignani.bsky.social · 07/05/2026

There is still time to register for Hot Topics in Basic and Translational Science @iaslc.bsky.social in Dublin, Ireland, June 26-27, 2026! ht26-iaslc.eventsair.site

ht26-iaslc.eventsair.site

Home

000

Paola A. Marignani @pmarignani.bsky.social · 04/05/2026

I am deeply honoured to receive the Alumni of Distinction Award for Excellence in Basic Science Research, Schulich School of Medicine and Dentistry 2026- Western University www.schulich.uwo.ca/about/news-e...

schulich.uwo.ca

Alumni of Distinction Awards celebrate impact and leadership - Schulich School of Medicine & Dentistry - Western University

This year’s six honourees exemplify excellence, with meaningful contributions across their professions and communities.

050

Paola A. Marignani @pmarignani.bsky.social · 25/04/2026

Today, April 25th, my family commemorates Festa della Liberazione. 🇮🇹 1945, the Italian Resistance, and Allied forces, liberated Italia from fascist dictatorship and Nazi occupation. We honor the courage of the Marchigiani partigiani who fought for the liberty Italy enjoys tod #25Aprile #Italy

060

Paola A. Marignani @pmarignani.bsky.social · 11/04/2026

Welcome back Earthlings👽😁🧑🏻‍🚀👨🏾‍🚀👨🏻‍🚀👨🏻‍🚀🚀🛸🌑

020

Paola A. Marignani @pmarignani.bsky.social · 06/04/2026

🌞☕👩🏻‍💻 Landscape and functional impact of variants of unknown significance of immune response genes in human cancer. www.linkedin.com/safety/go/?u...

linkedin.com

010

Reposted by Paola A. Marignani

Canadian Women in STEM @cdnwomenstem.bsky.social · 02/04/2026

#ChristinaKoch, first #Woman in history to the moon. Talk about breaking barriers. @cdnwomenstem.bsky.social #CDNWomenSTEM congratulates the little girl that had a big dream and the woman that fulfilled that dream. #STEMWomen #LeadByLifting 🚀🌘👩🏻‍🚀🫰🏻

063

Paola A. Marignani @pmarignani.bsky.social · 01/04/2026

🚀 History is happening. For the 1st time in 53yrs, humans are on their way to the Moon. NASA's #ArtemisII crew; Commander Reid Wiseman, Pilot Victor Glover, Mission Specialist Christina Koch, and 🇨🇦 astronaut Jeremy Hansen have lifted off aboard the Orion #NASA #Artemis #SpaceExploration #Moon

120

Paola A. Marignani @pmarignani.bsky.social · 27/03/2026

There is always room for Bibimbap.

020

Paola A. Marignani @pmarignani.bsky.social · 10/03/2026

What do Signal Transduction, Neural Networks, Artificial Intelligence and Agentics, all have in common? COMMUNICATION. Join us at @dalhousie.bsky.social for an afternoon of science, technology and Guglielmo Marconi. events.dal.ca/medicine/eve...

030

Paola A. Marignani @pmarignani.bsky.social · 09/03/2026

Please join us on March 11th to celebrate the Evolution of Communication: Marconi to Agentic AI. Faculty of Medicine,Tupper Medical Bldg,Theatre A,4pm. Welcome Italian Ambassador to Canada H.E Alessandro Cattaneo to @dalhousieu.bsky.social @dalhousie.bsky.social 🇨🇦🇮🇹 Open to our Halifax community.

042

Paola A. Marignani @pmarignani.bsky.social · 08/03/2026

Happy International Women's Day! Today, I am celebrating the incredible strength, resilience, and achievements of women that lift me. In a world facing instability, it's women and girls who are often most affected, facing increased risks and deeper inequalities. #InternationalWomensDay #IWD2026

071

Paola A. Marignani @pmarignani.bsky.social · 05/03/2026

At the end of the day.....of CIHR grant submission. 🎻

270

Paola A. Marignani @pmarignani.bsky.social · 04/03/2026

❄️☕👩🏻‍💻 🧐SCC demonstrates sensitivity with immunochemotherapy, but non-SCC, especially with KRAS+KEAP1/STK11 co-mutations, represents a distinct, immune-cold, high-risk subtype. www.jto.org/article/S155...

jto.org

Neoadjuvant Immunochemotherapy in Resectable NSCLC With SMARCA4 Alterations

Neoadjuvant immunochemotherapy has improved pathologic complete response (pCR) rates and event-free survival in resectable NSCLC, yet its efficacy in SMARCA4-altered NSCLC, a subset associated with po...

010

Paola A. Marignani @pmarignani.bsky.social · 17/02/2026

Am I the only one that becomes obsessed with #Olympic 🥌? Riveting at 5 am!!

120

Paola A. Marignani @pmarignani.bsky.social · 15/02/2026

Today is National Flag of Canada Day. At the stroke of noon on February 15, 1965, Canada's red and white maple leaf flag was raised for the very first time on Parliament Hill. 🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦

094

Reposted by Paola A. Marignani

BCCHR ResDev (DM) @resdevbcch.bsky.social · 12/02/2026

Wow. UBC has internal signature deadline that’s about 5 days before submission deadline, which is the day before CIHR deadline. People can work on Grant between signature deadline and submission deadline. (Schedule is advanced by ~1week if there’s a private sector partnership)

142

Paola A. Marignani @pmarignani.bsky.social · 12/02/2026

What is your University internal deadline like? Single deadline or double deadline? -CIHR LOI date Feb 4, 2026 -Dalhousie FoM internal deadline on Uni server Feb 12, 2026 -Dalhousie ORS internal deadline on Uni server & ResearchNet Feb 17, 2026 CIHR Deadline Mar 4, 2016 @dalhousieu.bsky.social

163

Paola A. Marignani @pmarignani.bsky.social · 11/02/2026

Today, on the #IWD2026, we celebrate the incredible contributions of women in STEM. It takes everyone working together to break down barriers and inspire the next generation of female scientists, innovators and tech entrepreneurs. @cdnwomenstem.bsky.social

020

Paola A. Marignani @pmarignani.bsky.social · 10/02/2026

❄️☕👩🏻‍💻 Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of #LKB1 and SYVN1 www.jci.org/articles/vie...

jci.org

JCI - Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1

020

Paola A. Marignani @pmarignani.bsky.social · 08/02/2026

❄️☕👩🏻‍💻 Alessia Cara's overview of the Olympic fire in Canada. Happy Sunday🥇🥈🥉 #MilanoCortina2026 youtube.com/watch?v=pmVK...

youtube.com

The Gold Within: Family & Fire #cbcsports #milanocortina2026

YouTube video by CBC Sports

010

Paola A. Marignani @pmarignani.bsky.social · 07/02/2026

Strategy preparation for hardware extraction🤞🏻next month. Reviewer 2, there is no alternative strategy, the metal has to go.🦵🏻⚙️

010

Reposted by Paola A. Marignani

Canadian Women in STEM @cdnwomenstem.bsky.social · 06/02/2026

Imagine that. Women need a Bill that ensures women's right to healthcare. If U are 🇨🇦, and an adult, U pay taxes that go towards our social healthcare system. Therefore, all persons in 🇨🇦 are entitled to healthcare equally. Again, all people are entitled to healthcare.

042

Paola A. Marignani @pmarignani.bsky.social · 06/02/2026

The second reading of Bill S-243. An act to establish a national framework for women's health in Canada. The Suffragette of 1917-1918 would be pleased. @cdnwomenstem.bsky.social

010

Reposted by Paola A. Marignani

Canadian Women in STEM @cdnwomenstem.bsky.social · 04/02/2026

Really sorry to hear that reviewers are abusing people with diseases. Hiding behind a screen does not take courage. It is cowardice. Bully tactics. Sad commentary on the quality of reviewers. In person review panels hold reviewers accountable. #CIHR being back in person review panels.

032

Paola A. Marignani @pmarignani.bsky.social · 04/02/2026

Reviewer#3, when applicant details life threatening disease(s) as reason 4 delayed productivity, you don't have 2 point out "concern 4 lack of productivity, though applicant has had health concerns". This comment is evil. Empathy is a sign of humanity. Do better! #CIHR being back F-2-F reviews.

291

Paola A. Marignani @pmarignani.bsky.social · 03/02/2026

13% success rates at #CIHR, is a really 87% fail rate for>4000 scientists. At a time when 🇨🇦 is investing millions to recruit more scientist into a broken funding environment. 🇨🇦, U need a strong science foundation 2 attract success. #CIHR, fix your science foundation, it is eroding in real time

35617