Two decades after the Human Genome Project, we finally have the ability to read the complete genome of any human and (nearly) any species. These sequences provide the ideal foundation for training pre...

In this Perspective article, a theoretical framework for how the AP-1 family of transcription factors mediates cellular adaptation in cancer drug resistance is proposed.

Aquesta tendència està creixent entre els col·lectius amb menys recursos

Cancer is a common cause of morbidity and mortality in domestic cats. Because the mutational landscape of domestic cat tumors remains uncharacterized, we performed targeted sequencing of 493 feline tu...

The study provides the most detailed spatiotemporal profile to date of early human midbrain development, offering a powerful new reference for neuroscience and regenerative medicine.

AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...

Risk associated with genetically defined forms of autism spectrum disorder (ASD) can propagate by means of transcriptional regulation to affect convergently dysregulated pathways, providing insight in...

Systematic screening of transcription factors reveals conserved mechanisms governing cortical radial glia lineage progression across primates and provides a framework for functional dissection of gene regulatory networks in human cortical neurogenesis.

Newly developed mouse models that enable cell-specific analyses of proteostasis dynamics across the lifespan of the mice reveal key aspects of neuronal proteostasis with ageing.

This strategic assessment explores how global biodiversity loss and the collapse of critical ecosystems could affect the UK’s resilience, security and prosperity.

November 2025 Hi! I am happy to share the first of (hopefully) some new graphics in this ‘climate viz of the month’ blog. For quite a few years now, I’ve been procrastinating on figuring out an eff…

Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.

Lineage tracing in human tissue samples from gestational weeks 16 to 24 provides insight into lineage relationships between cortical cell types and shows a switch in progenitor output from glutamaterg...

Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...

Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects ...