No abstract is available for this article.

Background The identification of sites of DNA replication initiation in mammalian cells has been challenging. Here, we present unbiased detection of replication initiation events in human cells using ...

Chromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the genomic localization and protein interactors, respectively, for a prote...

In response to DNA replication stress, DNA damage signaling kinases inhibit origin firing and promote the remodeling and stabilization of replication forks, leading to a systemic reduction in DNA synt...

Traditional peer review is slow, often delayed by the time-consuming process of identifying reviewers and lengthy review turnaround times. This study tests the feasibility of the Fast & Fair peer revi...

DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...

In recent years, several European countries, including France, have reduced their investment in scientific research, with biomedical research taking a significant hit. The primary casualty is basic re...

This study reveals that neutral lipids (NL), naturally present in cells, become trapped within genomic DNA as a consequence of the standard execution of the comet assay, a technique used to measure D...

The stability of the genome relies on Phosphatidyl Inositol 3-Kinase-related Kinases (PIKKs) that sense DNA damage and trigger elaborate downstream si…

Mashayekhi et al. demonstrate that polynucleotide kinase-phosphatase (PNKP) protects stalled replication forks from excessive degradation by preventing the accumulation of DNA ends with incompatible termini. Loss of PNKP leads to nascent DNA degradation via EXO1 exonuclease activity, independently of the BRCA2 pathway.