Conrad Nieduszynski @conradn.bsky.social · 18/04/2026Summer’s coming - relaxed cat on a warm roof! 030
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 03/03/2026The project initially focuses on potatoes, a globally important crop, with the goal of developing technology pipelines to fast-track #plantengineering. Find out more here - www.earlham.ac.uk/research-pro... @cgrandel.bsky.social @conradn.bsky.socialearlham.ac.ukEngineering Synthetic Plant Chromosomes (synPACs)Advances in synthetic genomics have opened new pathways for engineering biology, enabling the rapid design and construction of biological systems at scale for innovative applications and to address fu... 031
Reposted by Conrad NieduszynskiMax Reuter @reuterlm.bsky.social · 28/01/2026New preprint🎉 Happy to share our collaborative manuscript, where we provide in vivo and genome-wide evidence linking MCM2-7 helicase activation, DNA extrusion to initial origin melting, thereby adding a new mechanistic layer to how eukaryotic DNA replication is initiated. 👉 doi.org/10.64898/202...doi.org 1124
Reposted by Conrad NieduszynskiKennedy Institute of Rheumatology @kiroxford.bsky.social · 09/12/2025Hiring: Group Leader in Microbiome Studies! ✨ The successful candidate would establish & lead a new research group in human microbiome science, advancing understanding of microbe-microbe and microbe-host interactions in health & disease. Apply by 22 Dec. www.ndorms.ox.ac.uk/jobs/kennedy...ndorms.ox.ac.ukKennedy Trust for Rheumatology Research (KTRR) Group Leader in Microbiome Studies (183704)We are seeking applications from an outstanding scientist to establish and lead a new research group in human microbiome science, advancing understanding of microbe–microbe and microbe–host interactio... 069
Reposted by Conrad NieduszynskiAga Gambus @agagambus.bsky.social · 03/12/2025💡 PhD student position at the University of Birmingham, UK. Fully funded by MRC AIM doctoral training programme. 4 years. Open to 🇬🇧 🇪🇺 & 🌎. DNA replication 🧬 . Collaboration with Prof Andrew Wilson (Chemistry). Deadline midday (GMT) 9 January 2026. Please share 😀👍 www.findaphd.com/phds/project...findaphd.comPeptidomimetic Inhibition of DONSON/GINS as an experimental tool and potential an@cancer strategy at University of Birmingham on FindAPhD.comPhD Project - Peptidomimetic Inhibition of DONSON/GINS as an experimental tool and potential an@cancer strategy at University of Birmingham, listed on FindAPhD.com 066
Reposted by Conrad NieduszynskiMiguel Montez @miguelmontez.bsky.social · 13/11/2025📣 Looking for a 3-Year Postdoc @johninnescentre.bsky.social to join my Wellcome project. This is a highly interdisciplinary project that explores chromatin dynamics in 🌱 plant responses across timescales, from circadian rhythms to seasonal changes 📅 Closes on 10 Dec. www.jic.ac.uk/vacancies/36...jic.ac.ukPostdoctoral Researcher (Dr Miguel Montez) | John Innes CentreAn exciting opportunity has arisen for a Postdoctoral Researcher to join the Wellcome Trust project led by Dr Miguel Montez and hosted within the Dodd Group at the John Innes Centre. 03538
Reposted by Conrad NieduszynskiNature Reviews Molecular Cell Biology @natrevmcb.nature.com · 08/11/2025ICYMI: New Online! Discovery of a human gene encoding a cyclin-dependent kinasebit.lyDiscovery of a human gene encoding a cyclin-dependent kinaseNature Reviews Molecular Cell Biology, Published online: 05 November 2025; doi:10.1038/s41580-025-00926-0A study showing that human cells encode a functional cyclin-dependent kinase, thereby demonstrating that cell-cycle regulation is conserved across eukaryotes. 031
Reposted by Conrad NieduszynskiCarolina G @cgrandel.bsky.social · 29/10/2025We have a fully funded and exciting opportunity for a PhD project led by @conradn.bsky.social and the Biofoundry group to advance synthetic genomics @earlhaminst.bsky.social 013
Conrad Nieduszynski @conradn.bsky.social · 05/11/2025We have a 4 year fully-funded PhD opportunity to join our group @earlhaminst.bsky.social on an Eng Bio project: Engineering stable synthetic chromosomes. Jointly with the BioFoundry and @cgrandel.bsky.social. Read more about the project shorturl.at/GZMbB and about our research shorturl.at/HR6p5 155
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 29/10/2025PHD: Building on recent research to develop the first "designer" eukaryotic chromosome, this fully-funded #PhDproject with @conradn.bsky.social and @cgrandel.bsky.social will clarify and test the design principles for stable maintenance of fully synthetic chromosomes. buff.ly/l3dTmAf #synbiobuff.lyEngineering stable synthetic chromosomes4-year Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) PhD 042
Reposted by Conrad NieduszynskiStephen Turner @stephenturner.us · 15/10/2025From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes www.nature.com/articles/s41... 🧬🖥️🧪 github.com/HaploTeam/10... 0105
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 13/10/2025📣 Applications have just opened for our 2026 #PhD programme as part of the @nrpdtp.bsky.social and @aries-dtp.bsky.social! Begin your academic career with the expert scientists, technology, and facilities at the Earlham Institute in Norwich. buff.ly/327FNrX #genomics #findaphd #AcademicSky 136
Reposted by Conrad NieduszynskiAlper Akay @alperakay.bsky.social · 12/10/2025New BBSRC funded PhD opportunity in my group with Inspiralis Ltd and @conradn.bsky.social. If you are interested in RNA - protein interactions and RNA modifications check the details below for how to apply. @nrpdtp.bsky.social @biouea.bsky.social @earlhaminst.bsky.social tinyurl.com/bdzvn4drbiodtp.norwichresearchpark.ac.ukHow do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training PartnershipThis PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA supercoiling during replication and transcription. Using C... 01617
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 18/09/2025Fantastic to welcome researchers for another Norwich #Nanopore Day at the Earlham Institute - bringing together the research community using @nanoporetech.com! 🧬 022
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 29/09/2025📣 We're pleased to open applications for a new Group Leader in Artificial Intelligence (#AI) in Biology. Join our collaborative and inter-disciplinary research environment, exploring the natural world through the lens of #genomics. 🗓️ Applications close: 24 Oct ➡️ buff.ly/YRz3YLe #machinelearningbuff.lyGroup Leader: Artificial Intelligence (AI) in Biology 064
Reposted by Conrad NieduszynskiYasu Daigaku @yasudaigaku.bsky.social · 12/09/2025Our preprint on Pol-η usage during genome replication has been uploaded. It addresses the biased use of Pol-η in the lagging strand and late-replicating regions, which may be correlated with cancer mutagenesis. www.biorxiv.org/content/10.1...biorxiv.orgStrand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis.Efficient eukaryotic DNA replication relies on the coordinated actions of replicative and error-prone polymerases, with the latter providing flexibility at the cost of mutagenesis. DNA polymerase η (P... 0134
Reposted by Conrad NieduszynskiMathew Jones @jonesmjk.bsky.social · 01/09/2025Checkout our latest research in @natcomms.nature.com rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s teamrdcu.beA high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cellsNature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present... 23015
Reposted by Conrad Nieduszynskiliti_nice @litinice.bsky.social · 03/07/2025how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab) 0158
Reposted by Conrad NieduszynskiCarolina G @cgrandel.bsky.social · 22/07/2025@davideanne.bsky.social showing off our new protocol with the Opentrons 👏🏼🤖 @earlhaminst.bsky.social 023
Conrad Nieduszynski @conradn.bsky.social · 20/07/2025Ready for #Yeast2025 in Paris tomorrow. Looking forward to the science and to seeing colleagues and friends. 072
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 18/07/2025Next week at #Yeast2025 Dr Sathish Thiyagarajan will be presenting work from the @conradn.bsky.social group at the Earlham Institute using #nanopore #sequencing to identify pause sites in DNA replication. 📄 Plenary session 4 🗓️ Wednesday, 23 July 2025 🕤 9:30am - 11:00ambuff.lySingle-molecule identification of replication fork pause sites around highly transcribed genomic loci using nanopore sequencing 073
Reposted by Conrad NieduszynskiTatiana Moiseeva @tat1anamoiseeva.bsky.social · 17/07/2025Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social! www.sciencedirect.com/science/arti...sciencedirect.comFrom cooperation to conflicts – a complicated relationship between transcription and replication.A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated… 1258
Reposted by Conrad NieduszynskiAga Gambus @agagambus.bsky.social · 10/07/2025It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...academic.oup.comCDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDASAbstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic 13613
Reposted by Conrad NieduszynskiGilles FISCHER @gillesfischer.bsky.social · 09/06/2025📢 New paper out in Mol Syst Biol! During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬 🔗 www.embopress.org/doi/full/10.... 13414
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 12/06/2025💬 "These technologies have the power to remove breeding bottlenecks that have stymied development of new and improved #crops." A new project - funded by a £8.5M from @aria-research.bsky.social - will leverage advances in #engineeringbiology to establish #synthetic #plant chromosome technologies.buff.lyScientists look to biotechnology to improve crop resilience and nutritional valueA new project - funded by a £8.5M grant from the UK Government’s Advanced Research and Invention Agency (ARIA) - will leverage advances in engineering biology to establish synthetic plant chromosome… 012
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 08/06/2025Modern agriculture faces significant challenges, from climate change to soil degradation and food security. Scientists at the Earlham Institute are part of a new multi-million project developing #synthetic #plant #chromosome technologies to speed up the introduction of novel traits to plants.buff.lyScientists look to biotechnology to improve crop resilience and nutritional valueA new project - funded by a £8.5M grant from the UK Government’s Advanced Research and Invention Agency (ARIA) - will leverage advances in engineering biology to establish synthetic plant chromosome… 184
Reposted by Conrad NieduszynskiJosh T Cuperus @rnanerd.bsky.social · 04/06/2025Here ends our foray into rDNA variation in model organisms—w/ Christine Queitsch, Bonnie Brewer, and many others. Especially Ashley Hall and Elizabeth Morton. tl;dr: In natural ranges of rDNA copy number, phenotypes are rare (yeast + C. elegans). But outside those ranges? Some things happen. 1/3 191
Conrad Nieduszynski @conradn.bsky.social · 02/06/2025Very excited to be part of this project and to continue working with our longstanding collaborator, the amazing Yizhi (Patrick) Cai from @uommib.bsky.social 041
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 23/05/2025Great to welcome @adrianramsay.bsky.social MP for Waveney Valley, to the Earlham Institute and Norwich Research Park today. 021
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 23/05/2025💬 “When we looked at the replication start sites we’d identified, we discovered only 20% of them had been reported previously. The majority were newly discovered with this approach." 📃 Researchers use ultra #longreads to reveal #DNAreplication sites in the #humangenome. @conradn.bsky.socialbuff.lyStarting point of DNA replication mystery solvedThe question of where DNA replication starts in the human genome has finally been addressed, with the conclusion it is largely random. 031
Reposted by Conrad NieduszynskiEwan Birney @ewanbirney.bsky.social · 20/05/2025Basically molecular biologists can either use incorporation (eg, BrdU) or modification (eg, bacterial enzymes tethered to antibodies) or chemical modification (eg, radicals etc) and then the read out is the DNA (or RNA, see below). 122
Reposted by Conrad NieduszynskiEwan Birney @ewanbirney.bsky.social · 15/05/2025My amateur energy transition watching continues for GB grid. Reasonably windy days in the summer now have manageable gas peaks that could be replaced by batteries. I know there is a lot of battery storage going in so it will be interesting to see how this impacts the grid (from: grid.iamkate.com) 141
Reposted by Conrad NieduszynskiDeegan Lab @deeganlab.bsky.social · 15/04/20253rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴 www.biochemistry.org/events-and-t...biochemistry.orgUK DNA Replication Meeting 2026Research in the DNA replication field is progressing at a remarkable rate. Technological innovations in biochemical reconstitution, structural biology, proteomics and DNA sequencing are helping to rap... 02216
Reposted by Conrad NieduszynskiLawrence Freedman @ldfreedman.bsky.social · 13/05/2025Something a bit different from Comment is Freed - a guest post from Ilan Gur, the CEO of the UK government’s Advanced Research and Invention Agency (ARIA) on some of the technologies they ate exploring - on neurotechnologies, synthetic plants, and AI. (Free) samf.substack.com/p/three-tech...samf.substack.comThree technologies that can change the worldAnd how the UK can take the lead 0115
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 12/05/2025A study from the Earlham Institute and @ox.ac.uk has generated ultra #longread @nanoporetech.com reads, to reveal the majority of the human #genome is replicated from dispersed initiation sites, with around 80% of the sites never reported before. 🖥️🧬 @conradn.bsky.social @drkarimgharbi.bsky.socialbuff.lyStarting point of DNA replication mystery solvedThe question of where DNA replication starts in the human genome has finally been addressed, with the conclusion it is largely random. 053
Conrad Nieduszynski @conradn.bsky.social · 12/05/2025New paper! Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones genomebiology.biomedcentral.com/articles/10.... Identifying human DNA replication initiation sites on single molecules by @nanoporetech.com 1/7genomebiology.biomedcentral.comMost human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones - Genome BiologyBackground The identification of sites of DNA replication initiation in mammalian cells has been challenging. Here, we present unbiased detection of replication initiation events in human cells using ... 22212
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 07/05/2025Today we're looking forward to welcoming our Scientific Advisory Board - chaired by @katherinedenby.bsky.social - to a day of talks and presentations showcasing the latest from Earlham Institute scientists and technicians. Stay tuned as we share more throughout the day. 021
Reposted by Conrad NieduszynskiSarah Guiziou @sarah-guiziou.bsky.social · 15/04/2025🚨 PhD project alert: Engineering a soil bacteria to sense and record soil health. 🦠 🪴 🥼 🧑💻 🌍 Fully funded PhD studenship in my group, open for international students. @earlhaminst.bsky.social Please share widely! Deadline: 14th of May www.earlham.ac.uk/studentship/...earlham.ac.ukSentinel bacteria: engineering a soil bacteria to sense and record soil health 11315
Reposted by Conrad NieduszynskiAnthony Hall @ajwhall.bsky.social · 15/04/2025I have a PhD project funded by the John Innes Foundation, "Uncovering Genetic Drivers of Gene Expression in Elite Wheat Varieties", from the 1st of October 2025. #wheat #bioinformatics Apply now www.earlham.ac.uk/studentship/...earlham.ac.ukUncovering Genetic Drivers of Gene Expression in Elite Wheat Varieties 088
Reposted by Conrad NieduszynskiAlper Akay @alperakay.bsky.social · 09/04/2025MSCA postdoctoral fellowship applications are opening soon. If you are interested in applying and would like to join our lab to research RNA modifications and splicing, please get in touch by end of April. Check your eligibility at marie-sklodowska-curie-actions.ec.europa.eu/calls/msca-p...marie-sklodowska-curie-actions.ec.europa.euMSCA Postdoctoral Fellowships 2025MSCA Postdoctoral Fellowships enhance the creative and innovative potential of researchers holding a PhD and who wish to acquire new skills through advanced training, international, interdisciplinary ... 034
Reposted by Conrad NieduszynskiAlper Akay @alperakay.bsky.social · 16/03/2025We are advertising for a PhD position to study bacterial metabolites in C. elegans, funded by the MRC Microbes, Microbiomes and Bioinformatics training programme @uniofeastanglia.bsky.social @biouea.bsky.social. Open to UK and international students. www.findaphd.com/phds/project...findaphd.comUncovering bacterial metabolites that can attenuate vitamin B12 deficiency (AKAY_U25MMB) at University of East Anglia on FindAPhD.comPhD Project - Uncovering bacterial metabolites that can attenuate vitamin B12 deficiency (AKAY_U25MMB) at University of East Anglia, listed on FindAPhD.com 11422
Reposted by Conrad NieduszynskiDavid Eccles 🌻🇵🇸7x🩹🛡️ @gringene.org · 13/03/2025I've updated the introductory text on my nanopore notes page. These unstructured notes are a workaround for the Nanopore Community's shockingly bad search/discovery functions. If you'd like a nanopore notebook, please email / DM me so I can gauge interest. gringer.gitlab.io/presentation... 081
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 27/02/2025Make sure you join our NBRI Transformative Genomics User Meeting to hear @conradn.bsky.social discuss how ultra-long read sequencing reveals patterns of replication site initiation across the human genome. Join us here 👉 buff.ly/4blYAJl #genomics #sequencing @drkarimgharbi.bsky.social 033
Conrad Nieduszynski @conradn.bsky.social · 28/01/2025Interesting and important Guardian piece. I’d recommend reading this before trying DeepSeek. I’m sure other important examples will emerge over the coming days. 000
Reposted by Conrad NieduszynskiEarlham Institute @earlhaminst.bsky.social · 16/01/2025Catch our scientists at the #FestivalofGenomics later this month where they'll be discussing overcoming data challenges in #singlecell biology, and ultra #longread #sequencing in #DNAreplication.👇🧬🖥️ @flgenomics.bsky.social @drkarimgharbi.bsky.social @conradn.bsky.social @whatchamacaulay.bsky.social 163
Reposted by Conrad NieduszynskiLeopold Parts @leopoldparts.bsky.social · 15/01/2025We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 www.biorxiv.org/content/10.1... 318376
Reposted by Conrad NieduszynskiAdrien Leger @adrienleger.bsky.social · 28/11/2024We have been busing working on models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanoporetech.com direct RNA sequencing. This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩 33212
Reposted by Conrad NieduszynskiAga Gambus @agagambus.bsky.social · 10/01/2025A week left to apply for our MIBTP funded PhD program scholarship. DNA replication, structural biology, biochemistry… open to UK and international students. Supportive and international team 😀 www.findaphd.com/phds/project...findaphd.comVisualisation of the steps in the replisome assembly process. at University of Birmingham on FindAPhD.comPhD Project - Visualisation of the steps in the replisome assembly process. at University of Birmingham, listed on FindAPhD.com 075
Reposted by Conrad NieduszynskiEwan Birney @ewanbirney.bsky.social · 03/01/2025Some thoughts about what I am looking forward this year from my vantage point of computational molecular biology. One mega-trend for me; we will definitely see more AI methods of all sorts emerge. 16525