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Conrad Nieduszynski

@conradn.bsky.social
736 followers 372 following 30 posts

Research scientist; chromosome biology; DNA replication; genomics; nanopore sequencing Group leader at Earlham Institute, Norwich www.earlham.ac.uk/profile/conrad-ni… tinyurl.com/kvmdxdp8 ORDID: 0000-0003-2001-076X

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Conrad Nieduszynski @conradn.bsky.social · 18/04/2026
Summer’s coming - relaxed cat on a warm roof!
Cat amongst Wisteria on a sunny roof
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Earlham Institute @earlhaminst.bsky.social · 03/03/2026
The project initially focuses on potatoes, a globally important crop, with the goal of developing technology pipelines to fast-track #plantengineering. Find out more here - www.earlham.ac.uk/research-pro... @cgrandel.bsky.social @conradn.bsky.social
earlham.ac.uk
Engineering Synthetic Plant Chromosomes (synPACs)
Advances in synthetic genomics have opened new pathways for engineering biology, enabling the rapid design and construction of biological systems at scale for innovative applications and to address fu...
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Max Reuter @reuterlm.bsky.social · 28/01/2026
New preprint🎉 Happy to share our collaborative manuscript, where we provide in vivo and genome-wide evidence linking MCM2-7 helicase activation, DNA extrusion to initial origin melting, thereby adding a new mechanistic layer to how eukaryotic DNA replication is initiated. 👉 doi.org/10.64898/202...
doi.org
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Kennedy Institute of Rheumatology @kiroxford.bsky.social · 09/12/2025
Hiring: Group Leader in Microbiome Studies! ✨ The successful candidate would establish & lead a new research group in human microbiome science, advancing understanding of microbe-microbe and microbe-host interactions in health & disease. Apply by 22 Dec. www.ndorms.ox.ac.uk/jobs/kennedy...
ndorms.ox.ac.uk
Kennedy Trust for Rheumatology Research (KTRR) Group Leader in Microbiome Studies (183704)
We are seeking applications from an outstanding scientist to establish and lead a new research group in human microbiome science, advancing understanding of microbe–microbe and microbe–host interactio...
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Aga Gambus @agagambus.bsky.social · 03/12/2025
💡 PhD student position at the University of Birmingham, UK. Fully funded by MRC AIM doctoral training programme. 4 years. Open to 🇬🇧 🇪🇺 & 🌎. DNA replication 🧬 . Collaboration with Prof Andrew Wilson (Chemistry). Deadline midday (GMT) 9 January 2026. Please share 😀👍 www.findaphd.com/phds/project...
findaphd.com
Peptidomimetic Inhibition of DONSON/GINS as an experimental tool and potential an@cancer strategy at University of Birmingham on FindAPhD.com
PhD Project - Peptidomimetic Inhibition of DONSON/GINS as an experimental tool and potential an@cancer strategy at University of Birmingham, listed on FindAPhD.com
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Miguel Montez @miguelmontez.bsky.social · 13/11/2025
📣 Looking for a 3-Year Postdoc @johninnescentre.bsky.social to join my Wellcome project. This is a highly interdisciplinary project that explores chromatin dynamics in 🌱 plant responses across timescales, from circadian rhythms to seasonal changes 📅 Closes on 10 Dec. www.jic.ac.uk/vacancies/36...
jic.ac.uk
Postdoctoral Researcher (Dr Miguel Montez) | John Innes Centre
An exciting opportunity has arisen for a Postdoctoral Researcher to join the Wellcome Trust project led by Dr Miguel Montez and hosted within the Dodd Group at the John Innes Centre.
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 08/11/2025
ICYMI: New Online! Discovery of a human gene encoding a cyclin-dependent kinase
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Discovery of a human gene encoding a cyclin-dependent kinase
Nature Reviews Molecular Cell Biology, Published online: 05 November 2025; doi:10.1038/s41580-025-00926-0A study showing that human cells encode a functional cyclin-dependent kinase, thereby demonstrating that cell-cycle regulation is conserved across eukaryotes.
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Carolina G @cgrandel.bsky.social · 29/10/2025
We have a fully funded and exciting opportunity for a PhD project led by @conradn.bsky.social and the Biofoundry group to advance synthetic genomics @earlhaminst.bsky.social
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Conrad Nieduszynski @conradn.bsky.social · 05/11/2025
We have a 4 year fully-funded PhD opportunity to join our group @earlhaminst.bsky.social on an Eng Bio project: Engineering stable synthetic chromosomes. Jointly with the BioFoundry and @cgrandel.bsky.social. Read more about the project shorturl.at/GZMbB and about our research shorturl.at/HR6p5
Picture of colleagues outsideGroup picture in the institute
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Earlham Institute @earlhaminst.bsky.social · 29/10/2025
PHD: Building on recent research to develop the first "designer" eukaryotic chromosome, this fully-funded #PhDproject with @conradn.bsky.social and @cgrandel.bsky.social will clarify and test the design principles for stable maintenance of fully synthetic chromosomes. buff.ly/l3dTmAf #synbio
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Engineering stable synthetic chromosomes
4-year Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) PhD
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Stephen Turner @stephenturner.us · 15/10/2025
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes www.nature.com/articles/s41... 🧬🖥️🧪 github.com/HaploTeam/10...
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Conrad Nieduszynski @conradn.bsky.social · 15/10/2025
Congratulations Aykut & Alper!
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Earlham Institute @earlhaminst.bsky.social · 13/10/2025
📣 Applications have just opened for our 2026 #PhD programme as part of the @nrpdtp.bsky.social and @aries-dtp.bsky.social! Begin your academic career with the expert scientists, technology, and facilities at the Earlham Institute in Norwich. buff.ly/327FNrX #genomics #findaphd #AcademicSky
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Alper Akay @alperakay.bsky.social · 12/10/2025
New BBSRC funded PhD opportunity in my group with Inspiralis Ltd and @conradn.bsky.social. If you are interested in RNA - protein interactions and RNA modifications check the details below for how to apply. @nrpdtp.bsky.social @biouea.bsky.social @earlhaminst.bsky.social tinyurl.com/bdzvn4dr
biodtp.norwichresearchpark.ac.uk
How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training Partnership
This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA supercoiling during replication and transcription. Using C...
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Earlham Institute @earlhaminst.bsky.social · 18/09/2025
Fantastic to welcome researchers for another Norwich #Nanopore Day at the Earlham Institute - bringing together the research community using @nanoporetech.com! 🧬
The EI Advanced Training team welcome delegates to the Earlham Institute for Norwich Nanopore Day.Attendees networking during a break in the atrium of the Earlham InstituteAttendees networking during a break in the atrium of the Earlham InstituteAttendees networking during a break in the atrium of the Earlham Institute
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Earlham Institute @earlhaminst.bsky.social · 29/09/2025
📣 We're pleased to open applications for a new Group Leader in Artificial Intelligence (#AI) in Biology. Join our collaborative and inter-disciplinary research environment, exploring the natural world through the lens of #genomics. 🗓️ Applications close: 24 Oct ➡️ buff.ly/YRz3YLe #machinelearning
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Group Leader: Artificial Intelligence (AI) in Biology
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Yasu Daigaku @yasudaigaku.bsky.social · 12/09/2025
Our preprint on Pol-η usage during genome replication has been uploaded. It addresses the biased use of Pol-η in the lagging strand and late-replicating regions, which may be correlated with cancer mutagenesis. www.biorxiv.org/content/10.1...
biorxiv.org
Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis.
Efficient eukaryotic DNA replication relies on the coordinated actions of replicative and error-prone polymerases, with the latter providing flexibility at the cost of mutagenesis. DNA polymerase η (P...
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Mathew Jones @jonesmjk.bsky.social · 01/09/2025
Checkout our latest research in @natcomms.nature.com rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
rdcu.be
A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...
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liti_nice @litinice.bsky.social · 03/07/2025
how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)
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Carolina G @cgrandel.bsky.social · 22/07/2025
@davideanne.bsky.social showing off our new protocol with the Opentrons 👏🏼🤖 @earlhaminst.bsky.social
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Conrad Nieduszynski @conradn.bsky.social · 20/07/2025
Ready for #Yeast2025 in Paris tomorrow. Looking forward to the science and to seeing colleagues and friends.
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Earlham Institute @earlhaminst.bsky.social · 18/07/2025
Next week at #Yeast2025 Dr Sathish Thiyagarajan will be presenting work from the @conradn.bsky.social group at the Earlham Institute using #nanopore #sequencing to identify pause sites in DNA replication. 📄 Plenary session 4 🗓️ Wednesday, 23 July 2025 🕤 9:30am - 11:00am
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Single-molecule identification of replication fork pause sites around highly transcribed genomic loci using nanopore sequencing
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Tatiana Moiseeva @tat1anamoiseeva.bsky.social · 17/07/2025
Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social! www.sciencedirect.com/science/arti...
sciencedirect.com
From cooperation to conflicts – a complicated relationship between transcription and replication.
A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated…
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Aga Gambus @agagambus.bsky.social · 10/07/2025
It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
academic.oup.com
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS
Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic
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Gilles FISCHER @gillesfischer.bsky.social · 09/06/2025
📢 New paper out in Mol Syst Biol! During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬 🔗 www.embopress.org/doi/full/10....
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Earlham Institute @earlhaminst.bsky.social · 12/06/2025
💬 "These technologies have the power to remove breeding bottlenecks that have stymied development of new and improved #crops." A new project - funded by a £8.5M from @aria-research.bsky.social - will leverage advances in #engineeringbiology to establish #synthetic #plant chromosome technologies.
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Scientists look to biotechnology to improve crop resilience and nutritional value
A new project - funded by a £8.5M grant from the UK Government’s Advanced Research and Invention Agency (ARIA) - will leverage advances in engineering biology to establish synthetic plant chromosome…
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Earlham Institute @earlhaminst.bsky.social · 08/06/2025
Modern agriculture faces significant challenges, from climate change to soil degradation and food security. Scientists at the Earlham Institute are part of a new multi-million project developing #synthetic #plant #chromosome technologies to speed up the introduction of novel traits to plants.
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Scientists look to biotechnology to improve crop resilience and nutritional value
A new project - funded by a £8.5M grant from the UK Government’s Advanced Research and Invention Agency (ARIA) - will leverage advances in engineering biology to establish synthetic plant chromosome…
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Josh T Cuperus @rnanerd.bsky.social · 04/06/2025
Here ends our foray into rDNA variation in model organisms—w/ Christine Queitsch, Bonnie Brewer, and many others. Especially Ashley Hall and Elizabeth Morton. tl;dr: In natural ranges of rDNA copy number, phenotypes are rare (yeast + C. elegans). But outside those ranges? Some things happen. 1/3
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Conrad Nieduszynski @conradn.bsky.social · 02/06/2025
Very excited to be part of this project and to continue working with our longstanding collaborator, the amazing Yizhi (Patrick) Cai from @uommib.bsky.social
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Earlham Institute @earlhaminst.bsky.social · 23/05/2025
Great to welcome @adrianramsay.bsky.social MP for Waveney Valley, to the Earlham Institute and Norwich Research Park today.
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Earlham Institute @earlhaminst.bsky.social · 23/05/2025
💬 “When we looked at the replication start sites we’d identified, we discovered only 20% of them had been reported previously. The majority were newly discovered with this approach." 📃 Researchers use ultra #longreads to reveal #DNAreplication sites in the #humangenome. ‪@conradn.bsky.social
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Starting point of DNA replication mystery solved
The question of where DNA replication starts in the human genome has finally been addressed, with the conclusion it is largely random.
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Ewan Birney @ewanbirney.bsky.social · 20/05/2025
Basically molecular biologists can either use incorporation (eg, BrdU) or modification (eg, bacterial enzymes tethered to antibodies) or chemical modification (eg, radicals etc) and then the read out is the DNA (or RNA, see below).
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Ewan Birney @ewanbirney.bsky.social · 15/05/2025
My amateur energy transition watching continues for GB grid. Reasonably windy days in the summer now have manageable gas peaks that could be replaced by batteries. I know there is a lot of battery storage going in so it will be interesting to see how this impacts the grid (from: grid.iamkate.com)
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Deegan Lab @deeganlab.bsky.social · 15/04/2025
3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿 www.biochemistry.org/events-and-t...
biochemistry.org
UK DNA Replication Meeting 2026
Research in the DNA replication field is progressing at a remarkable rate. Technological innovations in biochemical reconstitution, structural biology, proteomics and DNA sequencing are helping to rap...
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Lawrence Freedman @ldfreedman.bsky.social · 13/05/2025
Something a bit different from Comment is Freed - a guest post from Ilan Gur, the CEO of the UK government’s Advanced Research and Invention Agency (ARIA) on some of the technologies they ate exploring - on neurotechnologies, synthetic plants, and AI. (Free) samf.substack.com/p/three-tech...
samf.substack.com
Three technologies that can change the world
And how the UK can take the lead
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Earlham Institute @earlhaminst.bsky.social · 12/05/2025
A study from the Earlham Institute and @ox.ac.uk has generated ultra #longread @nanoporetech.com reads, to reveal the majority of the human #genome is replicated from dispersed initiation sites, with around 80% of the sites never reported before. 🖥️🧬 @conradn.bsky.social @drkarimgharbi.bsky.social
buff.ly
Starting point of DNA replication mystery solved
The question of where DNA replication starts in the human genome has finally been addressed, with the conclusion it is largely random.
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Conrad Nieduszynski @conradn.bsky.social · 12/05/2025
New paper! Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones genomebiology.biomedcentral.com/articles/10.... Identifying human DNA replication initiation sites on single molecules by @nanoporetech.com 1/7
genomebiology.biomedcentral.com
Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones - Genome Biology
Background The identification of sites of DNA replication initiation in mammalian cells has been challenging. Here, we present unbiased detection of replication initiation events in human cells using ...
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Earlham Institute @earlhaminst.bsky.social · 07/05/2025
Today we're looking forward to welcoming our Scientific Advisory Board - chaired by @katherinedenby.bsky.social - to a day of talks and presentations showcasing the latest from Earlham Institute scientists and technicians. Stay tuned as we share more throughout the day.
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Sarah Guiziou @sarah-guiziou.bsky.social · 15/04/2025
🚨 PhD project alert: Engineering a soil bacteria to sense and record soil health. 🦠 🪴 🥼 🧑‍💻 🌍 Fully funded PhD studenship in my group, open for international students. @earlhaminst.bsky.social Please share widely! Deadline: 14th of May www.earlham.ac.uk/studentship/...
earlham.ac.uk
Sentinel bacteria: engineering a soil bacteria to sense and record soil health
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Anthony Hall @ajwhall.bsky.social · 15/04/2025
I have a PhD project funded by the John Innes Foundation, "Uncovering Genetic Drivers of Gene Expression in Elite Wheat Varieties", from the 1st of October 2025. #wheat #bioinformatics Apply now www.earlham.ac.uk/studentship/...
earlham.ac.uk
Uncovering Genetic Drivers of Gene Expression in Elite Wheat Varieties
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Alper Akay @alperakay.bsky.social · 09/04/2025
MSCA postdoctoral fellowship applications are opening soon. If you are interested in applying and would like to join our lab to research RNA modifications and splicing, please get in touch by end of April. Check your eligibility at marie-sklodowska-curie-actions.ec.europa.eu/calls/msca-p...
marie-sklodowska-curie-actions.ec.europa.eu
MSCA Postdoctoral Fellowships 2025
MSCA Postdoctoral Fellowships enhance the creative and innovative potential of researchers holding a PhD and who wish to acquire new skills through advanced training, international, interdisciplinary ...
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Alper Akay @alperakay.bsky.social · 16/03/2025
We are advertising for a PhD position to study bacterial metabolites in C. elegans, funded by the MRC Microbes, Microbiomes and Bioinformatics training programme @uniofeastanglia.bsky.social @biouea.bsky.social. Open to UK and international students. www.findaphd.com/phds/project...
findaphd.com
Uncovering bacterial metabolites that can attenuate vitamin B12 deficiency (AKAY_U25MMB) at University of East Anglia on FindAPhD.com
PhD Project - Uncovering bacterial metabolites that can attenuate vitamin B12 deficiency (AKAY_U25MMB) at University of East Anglia, listed on FindAPhD.com
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David Eccles 🌻🇵🇸7x🩹🛡️ @gringene.org · 13/03/2025
I've updated the introductory text on my nanopore notes page. These unstructured notes are a workaround for the Nanopore Community's shockingly bad search/discovery functions. If you'd like a nanopore notebook, please email / DM me so I can gauge interest. gringer.gitlab.io/presentation...
[image of my gitlab "Nanopore Notes" page]

People ask me from time to time about nanopore sequencing; I've started collating my responses and presentations, which you can find here. If you are interested in a book based around these notes, please email me so that I can gauge interest.

If you find these notes useful, please consider buying me a ko-fi. If you have a bioinformatics project in mind, I can help! Details about the services I offer can be found here:

https://www.gringene.org/services.html
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Earlham Institute @earlhaminst.bsky.social · 27/02/2025
Make sure you join our NBRI Transformative Genomics User Meeting to hear @conradn.bsky.social discuss how ultra-long read sequencing reveals patterns of replication site initiation across the human genome. Join us here 👉 buff.ly/4blYAJl #genomics #sequencing @drkarimgharbi.bsky.social
Graphic promoting the speakers at the NBRI Transformative Genomics User Group Meeting: Drivers of emerging multidrug resistance in human fungal pathogens by Mat Fisher, Imperial College London. Spatial transcriptomics reveals expression gradients in developing wheat inflorescences at cellular resolution, by Katie Long, John Innes Centre. Targeted long-read sequencing for somatic structural variant discovery in Multiple System Atrophy brains, by Caoimhe Morley, University College London. Ultra-long read sequencing resolves the pattern of replication site initiation across the human genome, byConrad Nieduszynski, Earlham Institute. Spatial transcriptomics and the ageing brain, by Aimée Parker, Quadram Institute.
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Conrad Nieduszynski @conradn.bsky.social · 28/01/2025
Interesting and important Guardian piece. I’d recommend reading this before trying DeepSeek. I’m sure other important examples will emerge over the coming days.
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Earlham Institute @earlhaminst.bsky.social · 16/01/2025
Catch our scientists at the #FestivalofGenomics later this month where they'll be discussing overcoming data challenges in #singlecell biology, and ultra #longread #sequencing in #DNAreplication.👇🧬🖥️ @flgenomics.bsky.social @drkarimgharbi.bsky.social @conradn.bsky.social @whatchamacaulay.bsky.social
Image promoting the Earlham Institute's participation at the Festival of Genomics and Biodata 2025, including details of two talks:

Iain Macaulay, Group Leader, participating in a panel discussion on 'Overcoming data challenges of high-resolution biology' on Thursday 30 January, from 16:05 to 17:05.

Karim Gharbi, Head of Technical Genomics, and Conrad Nieduszynski, Group Leader, will present a talk titled 'Ultra-long read sequencing resolves the pattern of DNA replication initiation across the human genome' on Thursday 30 January, from 16:35 to 17:05.
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Leopold Parts @leopoldparts.bsky.social · 15/01/2025
We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 www.biorxiv.org/content/10.1...
Enhancer scrambling strategy
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Adrien Leger @adrienleger.bsky.social · 28/11/2024
We have been busing working on models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanoporetech.com direct RNA sequencing. This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
Selected areas of Human rRNAs showing modification calls in IGV. Samples sequenced by ONT direct RNA sequencing with experimental Remora models calling m6A, m5C, PseudoU, and all 4 2'Ome modifications.
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Aga Gambus @agagambus.bsky.social · 10/01/2025
A week left to apply for our MIBTP funded PhD program scholarship. DNA replication, structural biology, biochemistry… open to UK and international students. Supportive and international team 😀 www.findaphd.com/phds/project...
findaphd.com
Visualisation of the steps in the replisome assembly process. at University of Birmingham on FindAPhD.com
PhD Project - Visualisation of the steps in the replisome assembly process. at University of Birmingham, listed on FindAPhD.com
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Ewan Birney @ewanbirney.bsky.social · 03/01/2025
Some thoughts about what I am looking forward this year from my vantage point of computational molecular biology. One mega-trend for me; we will definitely see more AI methods of all sorts emerge.
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