El estudio, de alcance mundial, analiza si en algunos casos las células humanas reparan mejor su ADN cuando el tratamiento contra el cáncer se realiza por la mañana temprano

The human genome encodes several hundreds of ubiquitin E3 enzymes, most of which have poorly understood biological roles. In search for novel ubiquitin E3 enzymes involved in DNA damage tolerance, we ...

A team at CABIMER has developed PLAMseq, a technique that for the first time enables the simultaneous identification of chromatin-associated proteins and their precise genomic locations within a singl...

PLAMseq enables performance of genomics and proteomics of chromatin-associated proteins and protein interactions simultaneously.

Chromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the genomic localization and protein interactors, respectively, for a prote...

Summary: Yck1/2 kinases regulate Mss4 phosphorylation and localization and affect multiple components of the TORC2 network, influencing lesser-known aspects of this signaling.

Here the authors identify PCNA, a master regulator of DNA replication, as a ubiquitin substrate for the BRCA1/BARD1 heterodimer. This modification is crucial to avoid the appearance of unreplicated DN...