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Benjamin Pardo

@pardolab.bsky.social

Ph.D in Biology. Particular interest in the molecular mechanisms of DNA replication and repair. Signaling of the DNA damage response. CNRS, University of Montpellier, France. www.igh.cnrs.fr/en/project/index/0/…

Posts Replies Media

Benjamin Pardo @pardolab.bsky.social · 15/04/2026

Today we are very pleased to share our latest article available now online @narjournal.bsky.social about the role of Slx4 scaffold and Fun30 (SMARCAD1 homolog) in DNA damage response regulation and replication fork protection against Top1-DNA crosslinks. academic.oup.com/nar/article/...

- Checkpoint signaling slows down replication in response to Top1 poisoning by camptothecin.
- Checkpoint signaling is actively dampened by Slx4 and Fun30 to permit Exo1-dependent resection of replication forks.
- Checkpoint dampening is critical to promote replication fork protection and preserve genome stability.

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Benjamin Pardo @pardolab.bsky.social · 15/04/2026

Today we are very pleased to share our latest article available now online @narjournal.bsky.social about the role of Slx4 scaffold and Fun30 (SMARCAD1 homolog) in DNA damage response regulation and replication fork protection against Top1-DNA crosslinks. academic.oup.com/nar/article/...

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