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Reposted by Ishita Ajith

PaquetLab @paquetlab.bsky.social · 05/08/2026

🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de published in @natneuro.nature.com: We developed a highly reproducible 3D human brain tissue model (3BTM) that enables studying microglial phenotypes in health and disease! #OA PDF here: rdcu.be/fxLou Thread👇: 1/11

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Reposted by Ishita Ajith

PaquetLab @paquetlab.bsky.social · 10/04/2026

🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de in STM @science.org! A human #iPSC-derived #Tauopathy model that endogenously develops late-stage Tau pathology. Free personal PDF: www.science.org/eprint/5H5YD.... Here's what we found👇 1/10

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Reposted by Ishita Ajith

Dementia Researcher @dementiaresearcher.bsky.social · 16/02/2026

LMU Klinikum Munich is recruiting a Postdoctoral Researcher in iPSC Models of Neurovascular Diseases at the Institute for Stroke & Dementia Research. Join PaquetLab to work on CRISPR, BBB modelling and neurovascular disease. Closing date: 17th April www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

dementiaresearcher.nihr.ac.uk

Postdoc Researchers: iPSC Models of Neurovascular Diseases

LMU Klinikum Munich seeks a Postdoctoral Researcher in iPSC neurovascular models at the Institute for Stroke and Dementia Research, PaquetLab.

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Ishita Ajith @ishitaajith.bsky.social · 24/03/2026

Thrilled to cap my time at Oxford with a first first-author paper in @alzdemjournals.bsky.social ! 🧠✨ Unveiling Aβ-independent effects of Module 42 (AD protein network) on immune function: 5 proteins boost phagocytosis, 7 modulate Ca²⁺ signaling (MDK & TMEFF2 nail both) PDF: doi.org/10.1002/alz....

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Reposted by Ishita Ajith

PaquetLab @paquetlab.bsky.social · 15/12/2025

New paper out today at @natneuro.nature.com in collab. with DichgansLab @isd-research.bsky.social @lmumuenchen.bsky.social: We developed a fully #iPSC-derived human model of the #BBB #blood-brain-barrier and applied it to study neurovascular disease (NVD)! #OA PDF here: rdcu.be/eUIl3 Thread👇 1/10

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Reposted by Ishita Ajith

PaquetLab @paquetlab.bsky.social · 12/03/2025

Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply

The research group of Prof. Dr. Dominik Paquet (https://www.isd-research.de/paquetlab) is looking for a Postdoc. Our research involves the development of human brain tissue models to study the molecular mechanisms of Alzheimer's disease, Frontotemporal dementia, stroke and other related brain diseases and to develop therapeutic approaches. We use state-of-the-art molecular and cell biological methods, such as induced pluripotent stem cells (iPSCs), advanced molecular biology techniques, CRISPR/Cas9 genome editing, brain tissue engineering, scRNAseq, proteomics etc. We offer a highly international, versatile, extremely well equipped and productive work environment.

We have received funding by an international research organization for a very interdisciplinary and collaborative project to develop a human iPSC model of the blood brain barrier and apply it to study neurovascular diseases, with a focus on Small vessel disease (SVD). The project will focus on CRISPR genome engineering of SVD-relevant mutations, differentiation of iPSCs into neurovascular cells, microfluidic 3D vascular tissue engineering, and identifying disease-relevant alterations by microscopy and omics techniques. It will be embedded in the highly collaborative and stimulating environment of the PaquetLab, ISD, SyNergy Cluster of Excellence, and our international collaboration network.

We are looking for a highly motivated individual with the following skills:

-extensive international scientific working experience in vascular
biology or a closely related research field (required)
-experience in molecular biology, biochemistry and/or omics
techniques; cell culture experience is a plus
-excellent English skills in speaking, writing about and
presenting scientific data
-interest in working in collaborative network of
friendly scientists around the world

A start date soon in 2025 is desired.

Join us!
dominik.paquet@med.uni-muenchen.de
www.isd-research.de/paquetlab
www.brenda-leducq.de

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