Angiosperm seed formation requires the coordinated development of the products of double fertilization—the embryo and the endosperm. The endosperm mediates efficient nutrient transfer from surrounding...

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Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...

This EMBO Workshop on Forces Across Scales will provide an integrative perspective on mechanobiology, a rapidly advancing field that examines how mechanical forces shape biological systems across mol…

In this Comment, we direct attention to initial efforts to establish a high-quality databank of atomic force microscopy (AFM) data: bioAFM-DB. We outline the state of this endeavor, its challenges, an...

Snake embryos coil, but how and why they corkscrew remains unexplored. Weber et al. find that the embryos wind up clockwise via buckling of the rapidly elongating axial body against the slow-growing, ...

Summary: A guide to mechanics in development: unlock how forces, material properties and geometry shape the forms of life.

Summary: A guide to mechanics in development: unlock how forces, material properties and geometry shape the forms of life.

Epithelial cells remodel their shape during phagocytosis while preserving tissue cohesion. Here, authors show that the E-cadherin/catenin adhesion complex is repurposed at phagocytic contacts, where i...

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

Set promotes cohesion removal in mitosis by evicting phosphorylated Histone H1 and counteracting Sgo1. In addition, Set promotes chromosome alignment by counteracting Aurora B activation. The underlyi...

We performed a comprehensive quantitative proteomic analysis of mouse oocytes using as few as 40 oocytes per condition, comparing wild-type and separase knockout oocytes at metaphase I and metaphase I...

The spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and fou...

Gastrulation is the morphogenetic process by which the single-layered pluripotent epiblast is reorganised into the three germ layers and the basic bod…

The mammalian liver possesses a regenerative capacity that is unmatched by any other organ. Following injury, liver epithelial cells can proliferate or even change their identity, enabling the organ t...

We seek a highly motivated Postdoctoral Research Associate to join the laboratory of Professor Kathy Niakan. We are based in the Loke Centre for Trophoblast Research (LCTR), in the Department of Physi...

For successful fertilization, sperm must recognize and penetrate the egg coat, called vitelline envelope (VE) or, in mammals, zona pellucida (ZP). In abalone, sperm acrosomal protein lysin dissolves t...