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Luca Jovine

@jovinelab.org
228 followers 195 following 63 posts

Professor of #StructuralBiology @karolinskainst.bsky.social studying #egg-#sperm interaction at #fertilization & #ZonaPellucida (ZP) module proteins Member of #EMBO & the #NobelAssembly at Karolinska Institutet More @ jovinelab.org

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Luca Jovine @jovinelab.org · 03/08/2026
New preprint: how does one sperm protein "key" recognize two different egg-coat receptors — the real "lock", and a decoy? www.biorxiv.org/content/10.6...
biorxiv.org
How a single sperm protein recognizes highly divergent egg coat components
For successful fertilization, sperm must recognize and penetrate the egg coat, called vitelline envelope (VE) or, in mammals, zona pellucida (ZP). In abalone, sperm acrosomal protein lysin dissolves t...
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CNRS @cnrs.fr · 23/07/2026
Hong Wang, a mathematician at the IHES Institute for Advanced Scientific Studies, has been awarded the prestigious Fields Medal for solving the Kakeya conjecture in three dimensions, in collaboration with Joshua Zahl. 🏅📚
news.cnrs.fr
Fields day for Hong Wang
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Luca Jovine @jovinelab.org · 06/07/2026
Looking forward to talk about egg coat structure and egg-sperm interaction @eshre.bsky.social 2026! #ESHRE2026 #zp #egg #sperm #fertilization #zonapellucida
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Luca Jovine @jovinelab.org · 01/07/2026
Susan was a bright and kind light in our world, who will be missed and remembered fondly
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Luca Jovine @jovinelab.org · 21/04/2026
Fun to talk about how #AlphaFold and #ROCKET can help #crystallography and #cryoEM studies of #fertilization at this year's American Society of Andrology meeting in Phoenix! andrologysociety.org/annual-meeti... #ASA #reproductivebiology #andrology
American Society of Andrology 2026 (ASA 2026)
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Flatiron Institute @flatironinstitute.org · 05/04/2026
#FlatironCCM researchers have developed a new tool called ROCKET that extends the capabilities of AlphaFold by directly learning from raw experimental data: bit.ly/4dUTZkG #science #math
simonsfoundation.org
Introducing ROCKET: An Upgrade to AlphaFold That Learns From Raw Experimental Data
Introducing ROCKET: An Upgrade to AlphaFold That Learns From Raw Experimental Data on Simons Foundation
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Luca Jovine @jovinelab.org · 01/04/2026
Starting from an #AlphaFold-Multimer prediction, we used #ROCKET to build a model of ZPD, a homopolymeric zona pellucida (#ZP) protein, into an initial #cryo-EM map at only ~9 Å resolution. A subsequently obtained 4.6 Å map highlighted how superior the ROCKET model was over the initial prediction:
ROCKET enables model building of a ZPD filament from low-resolution cryo-EM
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Luca Jovine @jovinelab.org · 01/04/2026
Very happy to have had a chance to attack an initially very low-resolution #cryo-EM map with #ROCKET! Thank you again @alisiafadini.bsky.social and all other co-authors of this important work, which truly shows the power of combining experimental structural biology and #AI inference. rdcu.be/fa9YH
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Luca Jovine @jovinelab.org · 11/03/2026
Nice to see our work on #ZP2-targeted female nonhormonal #contraception featured in today's @lemonde.fr: www.lemonde.fr/sciences/art... Merci Juliette Baëza! Original @pnas.org paper → www.pnas.org/doi/10.1073/...
lemonde.fr
La piste des anticorps comme moyen de contraception
Les recherches se multiplient pour utiliser ces protéines naturelles comme méthode contraceptive non hormonale. Mais leur mise sur le marché ne devrait pas intervenir avant dix ans ou quinze ans.
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Luca Jovine @jovinelab.org · 06/03/2026
Having a blast at XI NAZIONALE SIERR 2026 meeting in #Rome, with @enricabianchi.bsky.social and many other excellent italian scientists! www.sierr.it/eventi/xi-co...
sierr.it
XI NAZIONALE SIERR 2026
La SIERR è una società scientifica, senza finalità di lucro, costituita da Biologi, Biotecnologi e Medici che operano in laboratori di procreazione assistita.
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Luca Jovine @jovinelab.org · 16/02/2026
Delighted to deliver an invited lecture at this year's TI-FRIS/FRIS Symposium in Sendai! A highly interdisciplinary meeting bringing together diverse fields through excellent science: lnkd.in/d5XqH7ZV
TI-FRIS/FRIS Symposium 2026
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Luca Jovine @jovinelab.org · 24/01/2026
Thrilled to announce that the GRC Fertilization and Activation of Development and associated GRS will come to Europe for the first time in 2027! Join us in Noordwijk, the Netherlands, 31 July–6 August 2027. Mark your calendars and help us spread the word! #GRC #GRS #Fertilization #Development
GRC Fertilization and Activation of Development 2027 announcement
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Luca Jovine @jovinelab.org · 10/11/2025
Excited to attend this #SMART symposium on protein science in impressive Shenzhen!
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Luca Jovine @jovinelab.org · 29/10/2025
Long-awaited OpenFold3 is out!
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Luca Jovine @jovinelab.org · 14/08/2025
Great to get another peek at this story, after hosting @jacob-hanna.bsky.social as keynote speaker of our recent #GRC on Fertilization and Activation of Development!
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Luca Jovine @jovinelab.org · 22/07/2025
Excited that the Gordon Research Conference on Fertilization and Activation of Development 2025 (and associated GRS) is just a few days away! www.grc.org/fertilizatio... www.grc.org/fertilizatio... #GRC #GRS #fertilization #development #egg #sperm
Gordon Research Conference on Fertilization and Activation of Development 2025
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Luca Jovine @jovinelab.org · 13/07/2025
👍🎾🇮🇹
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Sergey Ovchinnikov @sokrypton.org · 12/07/2025
Molecular cat tweezers? 😺
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Meera Sundaram @meera-sundaram.bsky.social · 17/05/2025
Up on biorxiv! The tour de force protein tagging atlas for the #Celegans cuticle #aECM - from Jordan Ward @gotworms.bsky.social and Andrew Chisholm labs. So many beautiful images of cuticle collagen substructures !! www.biorxiv.org/content/10.1...
biorxiv.org
Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging
Barrier epithelia are shielded from the external environment by their apical extracellular matrices (aECMs). The molecular complexity of aECMs has challenged understanding of their organization in viv...
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Luca Jovine @jovinelab.org · 11/05/2025
Thanks @svtnyheter.bsky.social for covering our #ZP2 non-hormonal #contraception story! www.svt.se/nyheter/inri... @ki.se @esrf.fr @pnas.org @vetenskapsradet.bsky.social @kawresearch.bsky.social
svt.se
Ny forskning kan leda till hormonfritt preventivmedel
Jakten på ett hormonfritt preventivmedel har pågått i många år. Nu har forskare på KI upptäckt ett sätt att stoppa befruktning med hjälp av antikroppar. – Det hade gett kvinnor möjligheten att själva ...
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Luca Jovine @jovinelab.org · 30/04/2025
As an old tRNA aficionado, can't help loving this beautiful tour-de-force cryo-EM work on one of nature's coolest molecules! Congrats @sebastianglatt.bsky.social and colleagues!!!
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Luca Jovine @jovinelab.org · 23/04/2025
Changed handle to @jovinelab.org !
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Luca Jovine @jovinelab.org · 23/04/2025
www.forskning.se/2025/04/17/i...
forskning.se
Preventivmedel utan hormoner – med hjälp av antikroppar - forskning.se
Med hjälp av antikroppar kan man blockera befruktning på äggets yta. Nu har forskare tagit ett steg närmare ett hormonfritt preventivmedel.
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Luca Jovine @jovinelab.org · 14/04/2025
Thanks again @esrf.fr ! www.esrf.fr/sites/www/ho...
esrf.fr
Non-hormonal contraception visualised with X-rays
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Luca Jovine @jovinelab.org · 14/04/2025
New step taken towards non-hormonal contraception news.ki.se/new-step-tak...
news.ki.se
New step taken towards non-hormonal contraception
A new study from Karolinska Institutet shows how a small antibody fragment can block fertilisation by targeting a key protein on the surface of the egg. This discovery brings a non-hormonal contracept...
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Luca Jovine @jovinelab.org · 14/04/2025
Fresh off the press in @pnas.org: functional and structural studies of the interaction between #fertilization-blocking mAb IE-3 and mammalian #egg coat protein #ZP2 www.pnas.org/doi/10.1073/... Thanks to @vetenskapsradet.bsky.social @erc.europa.eu @embo.org @kawresearch.bsky.social @dfg.de
pnas.org
Structural basis of ZP2-targeted female nonhormonal contraception | PNAS
Monoclonal antibody IE-3 prevents mouse fertilization by binding ZP2, a major component of the oocyte-specific zona pellucida (ZP). We show that an...
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Luca Jovine @jovinelab.org · 07/03/2025
Just in time for 8 March, we are thrilled to open the way to targeted non-hormonal contraception with the first structure of a fertilization-blocking antibody bound to a key female reproductive protein, #ZP2: Structural basis of ZP2-targeted immunocontraception www.biorxiv.org/content/10.1...
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Luca Jovine @jovinelab.org · 27/02/2025
Happy to have played a small part in this nice story on our old friend #endoglin ! Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia www.nature.com/articles/s42... #ENG #preeclampsia #HHT
nature.com
Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia - Communications Biology
Thrombin cleaves membrane-bound endoglin and soluble endoglin, releasing fragments of varying sizes; these findings emphasize the heterogeneity of sEng in preeclampsia, connecting endothelial dysfunct...
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Luca Jovine @jovinelab.org · 05/02/2025
...they were indeed! 😊
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 31/01/2025
www.forbes.com/sites/roncar...
forbes.com
One More Time: Why Diversity Leads To Better Team Performance
Discussions on diversity in the workplace can be heated and contentious. But the data still shows more diverse teams outperform their less diverse peers. Here's how.
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Luca Jovine @jovinelab.org · 31/01/2025
Happy to have contributed (together with @arneelof.bsky.social, @enricabianchi.bsky.social and Gavin Wright) to this @elife.bsky.social special issue on reproductive heath: elifesciences.org/articles/102...
elifesciences.org
Special Issue: Reproductive health
The articles in this special issue highlight the diversity and complexity of research into reproductive health, including the need for a better understanding of the fundamental biology of reproduction...
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Luca Jovine @jovinelab.org · 30/01/2025
🤦 No comment... (and yes, when you'll translate it you will miss the nuances 😉) www.tidningencurie.se/debatt/under...
tidningencurie.se
Undervisning på engelska går ut över studenterna | Tidningen Curie
Det finns flera skäl att internationalisera högre utbildning. Men internationalisering är inte detsamma som anglifiering. Att undervisa på ett språk som inte är studenternas förstaspråk går ut över ut...
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Luca Jovine @jovinelab.org · 04/01/2025
What a heartwarming, progressive and - yes - casually illegal way to start the year 😞 edition.cnn.com/2025/01/04/e...
edition.cnn.com
Sweden allows nearly 10% of wolf population to be killed. The government wants an even more drastic cull | CNN
Sweden began its annual wolf hunt on Thursday, allowing nearly 10% of the endangered species population to be killed, as conservationists raise concerns about the controversial policy.
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Luca Jovine @jovinelab.org · 12/12/2024
Happy to bring the #ZP2 and egg coat filament story to HZB BESSY, where one the key datasets was collected!
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Luca Jovine @jovinelab.org · 10/12/2024
Here we go!
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Luca Jovine @jovinelab.org · 21/11/2024
Just got out of the supermarket with enough funding for my lab for the next 100 years 🤣
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