Analyses of deidentified data reveal complex interactions that quantify success at elite general science journals.

The recent launch of qed's "top 1%" preprint ranking has sparked controversy, with concerns about its arbitrary nature, potential harm to authors, and low-quality inclusions. While the tool aims to provide valuable feedback, backlash against qed and its partnership with bioRxiv highlights the challenges and complexities within the evolving preprint landscape and academic community.

Micrococcal nuclease (MNase) digestion is widely used to profile chromatin accessibility and nucleosome footprinting. However, its application is often limited by sensitivity to reaction conditions, h...

The Institute's Dr Osvaldo Contreras's work could one day help children born with heart defects and adults facing heart failure live longer, healthier…

Telomerase recruitment to telomeres is a tightly regulated process which is stimulated by replication stress. Here, the authors identify that nuclear filamentous actin is important for interaction bet...

Technical advances allow researchers to trace the genetic changes that occur over time.

Youlten, Miao et al. use zebrafish transplantation to understand the fate of cells lacking pluripotency factors Nanog, Pou5f3, and Sox19b (NPS) in developmental reprogramming and cell identity establishment. They found that NPS are required for proper cell identity for most, but not all, lineages, likely through nuclear and cytoplasmic reprogramming.

Our October webinar featured two early-career researchers working on development across scales. Here, we share the talks from Osvaldo Contreras (Victor

Biochemistry; Cell biology; Developmental biology; Computational bioinformatics

Multiomics analysis revealed the regulatory elements and transcription factors responsible for gonadal sex determination.

A biologist pushes back against attacks on curiosity-driven research

A personalized medicine pilot study samples a patient's transcriptome, proteome, and metabolome multiple times over the course of 14 months and integrates this information with whole-genome sequence d...

Limited color channels in fluorescence microscopy have long constrained spatial analysis in biological specimens. We introduce cycle hybridization chain reaction (cycleHCR), a method that integrates m...

3D human gastruloids mimic gastrulation and postgastrulation development, forming the three germ layer derivatives and hPGCLCs.

5-Ethynyl-2’-deoxyuridine (EdU) has transformed DNA replication and cell cycle analyses through fast and efficient click chemistry detection. However, commercial EdU kits are expensive, contain propri...

5-Ethynyl-2’-deoxyuridine (EdU) has transformed DNA replication and cell cycle analyses through fast and efficient click chemistry detection. However, commercial EdU kits are expensive, contain propri...

Abstract. Cell cycle checkpoints are the regulatory mechanisms that secure the strict order of cellular events for cell division that ensure genome integri

Gene transcription is an emergent phenomenon of packing domain geometry in situ.

Light exerts circadian-independent effects on glucose and lipid metabolism.