Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

Multiomics analysis revealed the regulatory elements and transcription factors responsible for gonadal sex determination.

Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.

The study is the first to show that low iron levels can affect fetal sexual development.

Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.

Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...

A hormone-free male birth control pill is undergoing clinical testing for the first time ever.

1h 55m | PG-13

Exonic enhancers are a widespread class of dual-function regulatory elements https://t.co/Ho0TdalAsu #biorxiv_genomic

Our research is focused on understanding how genetic changes in the non-coding genome can impact gene regulatory mechanisms, alter developmental processes and ultimately affect human craniofacial shap...

Such a shift would “put us back in the dark ages in terms of our science,” says neuroscientist Anne Murphy, who helped to formulate the original policy.

שלושה חוקרים ממכון ויצמן למדע, שלושה מהאוניברסיטה העברית, שניים מהטכניון, שניים מבית החולים שיבא, חוקר מאוניברסיטת תל אביב וחוקרת מאוניברסיטת בר-אילן יקבלו מהאיחוד האירופי מענק "הוכחת היתכנות", שנועד ...

Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...

The Goodman Faculty of Life Sciences at Bar-Ilan University is recruiting candidates for tenure-track senior academic positions Start Date: October 1, 2025   Join a young and dynamic faculty (most of ...