The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and different conditions. Human induced pluripotent stem cells are uniquely suited to ...

Identifying chemical compounds that target trans-regulatory networks (TRNs) underlying molecular programs of cells for directed cellular conversion (i.e. differentiation, reprogramming, transdifferent...

Learn how to use the tools you need to apply bioinformatics techniques in your own research.

Hematopoietic stem cells (HSCs) derived from human induced pluripotent stem cells (iPS cells) have important biomedical applications. We identified differentiation conditions that generate HSCs defined by robust long-term multilineage engraftment in ...

Our mission: Marsupial conservation and de-extinction of the thylacine Over the past decade, the concept of de-extinction has transitioned out of the realm

In this article, Wells and colleagues present the first systematic FAIR evaluation of stem cell data infrastructures. Case studies from, but not limited to, the United States, Japan, Europe, and Austr...

Keynote Day 2 Session Chair: Shyam Prabhakar Speaker:

Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.

BioModels is a repository of freely-available mathematical models of biological and biomedical systems. It hosts a vast selection of physiologically and pharmaceutically relevant mechanistic models in...

Our Center carries out research & technology development; we engage in collaborative research projects with the community; we provide services for biological researchers, and dissemination and educati...

Triple negative breast cancer (TNBC) is a heterogeneous group of tumors which lack estrogen receptor, progesterone receptor, and HER2 expression. Targeted therapies have limited success in treating TN...

By learning to embed DNA k-mers and cells into a joint space, CellSpace improves single-cell ATAC-seq analysis in multiple tasks such as latent structure discovery, transcription factor activity infer...

npj Systems Biology and Applications - Cyclin/Forkhead-mediated coordination of cyclin waves: an autonomous oscillator rationalizing the quantitative model of Cdk control for budding yeast

The 2025 Gordon Research Conference on Developmental Biology will be held in Pomona, California. Apply today to reserve your spot.