iiinova — where your digital self keeps evolving

Olivier Neyrolles @oneyrolles.bsky.social · 13/09/2026

The fun part: we had been working with H37Rv without realizing this. A discussion with Heran made the two stories click. Together, the papers connect copper sensing, cysteine metabolism, redox homeostasis and Mtb fitness. Kudos to Wendy, Florence, Daisy and all co-authors. @asm.org #Tuberculosis

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Olivier Neyrolles @oneyrolles.bsky.social · 13/09/2026

Independently, @heran.bsky.social’s lab found that CysK2 is required for copper resistance—and that H37Rv carries a hypomorphic S93G allele that helps explain its unusual copper sensitivity. A hidden strain peculiarity with big consequences. 📖 shorturl.at/gzFxj

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Olivier Neyrolles @oneyrolles.bsky.social · 13/09/2026

𝐓𝐰𝐨 𝐬𝐭𝐮𝐝𝐢𝐞𝐬, 𝐨𝐧𝐞 𝐬𝐭𝐨𝐫𝐲: 𝐜𝐨𝐩𝐩𝐞𝐫, 𝐜𝐲𝐬𝐭𝐞𝐢𝐧𝐞 𝐚𝐧𝐝 𝐫𝐞𝐝𝐨𝐱 𝐚𝐝𝐚𝐩𝐭𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝑴. 𝒕𝒖𝒃𝒆𝒓𝒄𝒖𝒍𝒐𝒔𝒊𝒔 Our new @mbio.bsky.social paper shows that copper reaches intracellular M. tuberculosis and strongly induces CysK2, a cysteine synthase linking copper sensing to redox adaptation and persistence. 📖 shorturl.at/PSDbk

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Luiz Pedro Carvalho, PhD @luizcarvalholab.bsky.social · 21/08/2026

Wow. In a previously unknown toxin-antitoxin system (RelS-RelI) the RelS toxin halts bacterial growth by cleaving 16S rRNA at a unique site in the anti-Shine-Dalgarno region. Beautiful use of comparative genomics at the species level, powerful. @oneyrolles.bsky.social Makarova & Genevaux.

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CNRS Biologie @cnrsbiologie.bsky.social · 02/07/2026

#ResultatScientifique🔎| Camille Attané et ses collaborateurs décrivent une population de cellules jusqu'alors inconnue dans la moelle osseuse humaine ! 👋 @ipbstoulouse.bsky.social 📕 @cp-cellreports.bsky.social À lire sur notre site internet ! ⤵️

buff.ly

Un nouveau type de cellules graisseuses sans noyau découvertes dans la moelle osseuse humaine

Dans u

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Alexandra Delbot @alexandradelbot.bsky.social · 02/06/2026

Une méta-analyse de 100 études menées dans 36 pays montre que les citoyens préfèrent généralement les migrants qualifiés et maîtrisant la langue du pays d’accueil. Mais elle révèle aussi des attitudes envers l'immigration globalement plus positives que ne le suggère le débat public.

radiofrance.fr

Attitudes face à l'immigration : préfère-t-on certains immigrés à d'autres ?

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CNRS @cnrs.fr · 30/05/2026

Le #CNRS perd aujourd'hui l'une de ses figures les plus marquantes. Sociologue, penseur de la complexité et directeur de recherche émérite, #EdgarMorin a consacré sa vie à faire dialoguer les disciplines pour mieux comprendre le monde et l'humain. lejournal.cnrs.fr/articles/edg...

lejournal.cnrs.fr

Edgar Morin, un cheminement intellectuel

Edgar Morin est décédé ce 29 mai 2026. Nous republions ici le portrait que nous avions consacré à l’intellectuel le plus célèbre de France lors de son centenaire, retraçant huit décennies d’un parcour...

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jobRxiv @jobrxiv.org · 24/03/2026

Karolinska Institute is hiring for 9 new positions! Individual job details below!👇 #ScienceJobs

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Olivier Neyrolles @oneyrolles.bsky.social · 19/03/2026

Truly humbled and deeply honored to have been elected a Fellow of the European Academy of #Microbiology, @femsmicro.org Profoundly grateful to my mentors, collaborators, colleagues, and students, past and present, whose guidance, creativity, and dedication have shaped this journey 🙏 ♥️

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Olivier Neyrolles @oneyrolles.bsky.social · 17/03/2026

Any idea if she’ll be touring in Toulouse in 2027 or 2028?

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Alexandre Gouzy @alexandregouzy.bsky.social · 11/03/2026

I’m pleased 🤗 to share our new preprint exploring the mode of action and resistance of the antitubercular drug pyrazinamide (PZA) 💊 Thanks to everyone who have participated 🙌 We hope these findings will help the fight against drug resistance in tuberculosis. www.biorxiv.org/content/10.6...

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Olivier Neyrolles @oneyrolles.bsky.social · 12/03/2026

AI agent Fleming accelerates antibiotic discovery for Mycobacterium tuberculosis by integrating generative and predictive models, achieving 83% in-vitro hit rates and identifying novel compounds with favorable ADMET profiles across unexplored chemical space. www.biorxiv.org/content/10.1...

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 25/02/2026

🚨 𝐀𝐈 𝐦𝐞𝐞𝐭𝐬 𝐓𝐁 𝐝𝐫𝐮𝐠 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲! Imaging 𝐶. 𝑔𝑙𝑢𝑡𝑎𝑚𝑖𝑐𝑢𝑚 (a model for 𝑀. 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠) + deep learning reveals known, unseen, and novel antibiotic modes of action from images alone, a leap for TB drug discovery. ✍️ @awehenkel.bsky.social & coll. 📖 shorturl.at/9QPDy #Tuberculosis #MicroSky

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Geanncarlo Lugo @gclugo.bsky.social · 20/02/2026

Our new paper is out in @lsajournal.org We explored how glycolysis inhibition in tuberculosis-infected macrophages can reduce HIV-1 spread. 🔗 Read it here: doi.org/10.26508/lsa... Huge thanks to @Zoi Vahlas, @lucianabalboa.bsky.social, @oneyrolles.bsky.social & @chrisverollet.bsky.social

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Olivier Neyrolles @oneyrolles.bsky.social · 13/02/2026

Thank you @embojournal.org! 🙏 The editorial process was genuinely exceptional: thoughtful, collaborative, and constructive. If only all journals had editors who truly act as editors!

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The EMBO Journal @embojournal.org · 13/02/2026

How can bacterial pathogens weather metal ion stress during infection? @pierredupuy.bsky.social, @oneyrolles.bsky.social et al implicate ‘effluxosomes’, membrane clusters of metal-binding chaperones & exporters coordinating M. tuberculosis resistance to toxic metals link.springer.com/article/10.1...

link.springer.com

Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal

Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

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CNRS Biologie @cnrsbiologie.bsky.social · 13/02/2026

#ResultatScientifique🔎| La bactérie responsable de la tuberculose est capable d'évacuer les métaux toxiques pour résister au système immunitaire ✍️ @oneyrolles.bsky.social 🤝 @ipbstoulouse.bsky.social 📕 buff.ly/4R5iaMB ▶️

buff.ly

Tuberculose : comment la bactérie évacue les métaux toxiques pour résister au système immunitaire

Le bacille de la tuberculose survit dans les cellules immunitaires en neutralisant des métaux toxiques comme le zinc.

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Olivier Neyrolles @oneyrolles.bsky.social · 13/02/2026

Beyond the science, I want to highlight the peer review at @embojournal.org—truly constructive, collaborative, and scientific dialogue that strengthened the work at every step.

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Olivier Neyrolles @oneyrolles.bsky.social · 13/02/2026

Conceptually, this work: 🔬 Introduces effluxosomes as a new paradigm for bacterial membrane organization 🧪 Shows how pathogens coordinate multi-metal resistance 💊 Opens potential avenues for new antimicrobials against tuberculosis.

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Olivier Neyrolles @oneyrolles.bsky.social · 13/02/2026

PacL1 acts as a multi-substrate metallochaperone, and the effluxosomes connect to a broad interaction network—these are not isolated modules but part of a coordinated stress adaptation program. ...

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Olivier Neyrolles @oneyrolles.bsky.social · 13/02/2026

Using single-particle tracking and single-molecule super-resolution microscopy, we show these effluxosomes are highly dynamic, stabilizing metal-export pumps and coordinating resistance to zinc, cadmium & copper. ...

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Olivier Neyrolles @oneyrolles.bsky.social · 13/02/2026

The bacterium assembles dynamic membrane platforms organized by PacL proteins, clustering P-type ATPase pumps into functional complexes we call “effluxosomes.” ...

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Olivier Neyrolles @oneyrolles.bsky.social · 13/02/2026

🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥! After 8 months of revision, our work is now online: shorturl.at/WHmFq We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection. ...

shorturl.at

Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal

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Olivier Neyrolles @oneyrolles.bsky.social · 29/01/2026

So inspiring to see the next generation of researchers in action. Their science gets clearer and more impactful every year. Watching Max Caouaille and Aizat Abdul at #TBVAC was genuinely moving. Great science, great storytelling, huge passion. The future of research is in very good hands. 👏

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Daniel L. Barber, PhD @danbarberphd.bsky.social · 15/01/2026

The Barber lab is looking to hire post-docs to work on #tuberculosis #immunology using murine and NHP models. BSL3 experience not required. Check out our lab in the NIH intramural program in Bethesda MD!

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Max Gutierrez @maxgg.bsky.social · 12/01/2026

A great meeting ahead for host and pathogen aficionados! Keynote speakers: Florence Niedergang (Cochin) and Raphael Valdivia (Duke)- plenty of opportunities for early career researchers to present their work and a very collegial and supportive network. Belfast here we go! Please repost.

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Olivier Neyrolles @oneyrolles.bsky.social · 13/01/2026

These findings open new avenues for targeting monocyte mobilization in inflammatory diseases, infections, and autoimmune disorders like lupus. 🙌 Huge thanks to the team, and our collaborators! Supported by @agencerecherche.bsky.social, @frm-officiel.bsky.social, and Bettencourt Schueller Foundation.

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Olivier Neyrolles @oneyrolles.bsky.social · 13/01/2026

... 🔹 NCAM1 is the main polysialic acid carrier in inflammatory monocytes, and its loss phenocopies ST8SIA4 deficiency. 🔹 Polysialylation regulates CCR2 surface distribution, cytoskeleton, and chemokine binding, revealing a new mechanism controlling immune cell trafficking.

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Olivier Neyrolles @oneyrolles.bsky.social · 13/01/2026

Key findings include: 🔹 Human 𝑆𝑇8𝑆𝐼𝐴4 variants are associated with lower monocyte and lymphocyte counts and higher SLE risk. 🔹 ST8SIA4 deficiency causes monocytopenia in mice by impairing CCR2-dependent monocyte exit from bone marrow. ...

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Olivier Neyrolles @oneyrolles.bsky.social · 13/01/2026

Inflammatory monocytes are critical for fighting infections (like tuberculosis) and regulating inflammation. We found that the enzyme ST8SIA4, through polysialylation, controls their egress from the bone marrow via the CCR2 receptor, both at steady state and during 𝑀. 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 infection.

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Olivier Neyrolles @oneyrolles.bsky.social · 13/01/2026

🥳 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐥𝐚𝐭𝐞𝐬𝐭 𝐰𝐨𝐫𝐤 𝐬𝐡𝐨𝐰𝐢𝐧𝐠 𝐡𝐨𝐰 𝐩𝐨𝐥𝐲𝐬𝐢𝐚𝐥𝐲𝐥𝐚𝐭𝐢𝐨𝐧, 𝐚 𝐫𝐚𝐫𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐦𝐨𝐝𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧, 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐦𝐨𝐧𝐨𝐜𝐲𝐭𝐞 𝐦𝐨𝐛𝐢𝐥𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐛𝐨𝐧𝐞 𝐦𝐚𝐫𝐫𝐨𝐰. ✍️ Aurélien Boyancé, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social 📖 shorturl.at/IDwza 👇 A short thread...

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Olivier Neyrolles @oneyrolles.bsky.social · 08/01/2026

Nothing like a good meal with an even better team. Here’s to a bright, productive 2026! 🤩 @mcaouaille.bsky.social @saurabhchugh09.bsky.social @vogeleerp.bsky.social @yoannrombouts.bsky.social & more!

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Bryan Bryson @thebrysonlab.bsky.social · 18/12/2025

Two pieces of fun news: 1. We've launched a new website for our lab: www.brysonlab.org 2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!

brysonlab.org

The Bryson Lab | Vaccine Development & Research at MIT

Developing effective accessible vaccines to end tuberculosis worldwide. Combining immunoengineering, molecular microbiology & systems biology at MIT.

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IPBS Toulouse @ipbstoulouse.bsky.social · 18/12/2025

🚨 We are excited to announce that @virginiestevenin.bsky.social has been awarded a starting grant from the @frm-officiel.bsky.social to establish her research team at IPBS and study the nutrition of pathogenic bacteria inside human host cells. More info: shorturl.at/U6zSa #MicroSky #Salmonella

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Olivier Neyrolles @oneyrolles.bsky.social · 12/12/2025

A big thank-you to @sheetalgandotra.bsky.social & @vivekrao.bsky.social and everyone at CSIR-IGIB for their warm welcome! 😊 What a wonderful day with incredibly friendly hosts and such brilliant, motivated students! 🇫🇷🇮🇳 Long live Franco-Indian cooperation!

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Olivier Neyrolles @oneyrolles.bsky.social · 11/12/2025

Huge congratulations to the entire team and to @mcaouaille.bsky.social for this outstanding PhD thesis work; an ambitious, beautifully executed study that pushes both TB immunology and intravital imaging into entirely new territory. #Tuberculosis #ImmunoSky #MicroSky #Microscopy

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Olivier Neyrolles @oneyrolles.bsky.social · 11/12/2025

Combined with spectral cytometry and single-cell RNA-seq, these findings reveal how IFN-I–driven pathology creates physical and molecular barriers that undermine adaptive immunity, and how targeting this axis may reopen the path for effective T cell–mediated control of TB.

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Olivier Neyrolles @oneyrolles.bsky.social · 11/12/2025

𝗨𝘀𝗶𝗻𝗴 𝘁𝗵𝗶𝘀 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵, 𝘄𝗲 𝗳𝗼𝘂𝗻𝗱 𝘁𝗵𝗮𝘁: • Without SP140, excess IFN-I traps CD8⁺ and CD4⁺ T cells and prevents their movement in lesions. • The few T cells that enter become almost immobile. • Blocking IFNAR fully restores T cell motility and surveillance.

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Olivier Neyrolles @oneyrolles.bsky.social · 11/12/2025

🔬 𝗙𝗶𝗿𝘀𝘁-𝗲𝘃𝗲𝗿 𝗶𝗻𝘁𝗿𝗮𝘃𝗶𝘁𝗮𝗹 𝗹𝘂𝗻𝗴 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆 𝗶𝗻 𝗧𝗕 allowed us to watch T cells in real time inside infected lesions, an unprecedented view made possible by the work of Emma Lefrançais, Léa Fromont & colleagues. Preprint here: shorturl.at/gm20H

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Olivier Neyrolles @oneyrolles.bsky.social · 11/12/2025

🚨 𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐟𝐫𝐨𝐦 𝐨𝐮𝐫 𝐥𝐚𝐛, 𝐚𝐧𝐝 𝐚 𝐟𝐢𝐫𝐬𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐓𝐁 𝐟𝐢𝐞𝐥𝐝! 🚨 We’re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses. 📖 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁: shorturl.at/r5jd9

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Olivier Neyrolles @oneyrolles.bsky.social · 05/12/2025

𝗜𝗣𝗕𝗦 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵𝗲𝗿𝘀 𝗶𝘀𝗼𝗹𝗮𝘁𝗲𝗱 𝗵𝘂𝗺𝗮𝗻 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗼𝗿𝘆 𝗯𝗼𝗻𝗲 𝗺𝗮𝗿𝗿𝗼𝘄 𝗮𝗱𝗶𝗽𝗼𝗰𝘆𝘁𝗲𝘀 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗳𝗶𝗿𝘀𝘁 𝘁𝗶𝗺𝗲! These anucleate fat cells still metabolize lipids and glucose, support blood cell production, and may shape the bone marrow niche and hematopoiesis.🩸 📖 shorturl.at/bunUV #Hematopoiesis #Adipocytes #BoneMarrow

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Joanne Flynn @joanneflynn19.bsky.social · 04/12/2025

Hey friends. I’m looking for a postdoc interested in studying host-pathogen interactions and immunology of tuberculosis. Send me some good people! We have a great group here! Email me joanne@pitt.edu. Thanks!

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IPBS Toulouse @ipbstoulouse.bsky.social · 03/12/2025

IPBS researchers created LiveLung-TB, a BSL-3 imaging platform that visualizes real-time immune responses in Mtb-infected lungs. They found most CD4 T cells fail to reach infected cells, revealing physical barriers that limit TB immunity—a new window into host-pathogen dynamics! 🔬🫁 #Tuberculosis

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