A deeper understanding of how tissue-localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no mu…

Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

Developing effective accessible vaccines to end tuberculosis worldwide. Combining immunoengineering, molecular microbiology & systems biology at MIT.

Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper under...

T cells have an essential role in immune responses to Mycobacterium tuberculosis, but the mechanisms by which they may provide protective immunity remain poorly understood. This Review explores the kn...

Blanchard et al. reveal that Fc-optimized anti-CTLA-4 antibodies remodel tumor vasculature and increase tumor-associated high endothelial venules (TA-HEVs) that support T cell recruitment into tumors....

Pêcheurs au retour de pêche, langue de Barbarie. Saint-Louis / Sénégal – Crédits : IRD,[…]

The traditional view of metabolism as merely supplying energy and biosynthetic precursors is undergoing a paradigm shift. Metabolic dynamics not only …