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Pierre Dupuy

@pierredupuy.bsky.social
138 followers 176 following 2 posts

CNRS researcher. PhD in Microbiology. Mycobacteria, Stress response, DNA repair.

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Reposted by Pierre Dupuy
Olivier Neyrolles @oneyrolles.bsky.social · 13/02/2026
🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥! After 8 months of revision, our work is now online: shorturl.at/WHmFq We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection. ...
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Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal
Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...
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CNRS Biologie @cnrsbiologie.bsky.social · 13/02/2026
#ResultatScientifique🔎| La bactérie responsable de la tuberculose est capable d'évacuer les métaux toxiques pour résister au système immunitaire ✍️ @oneyrolles.bsky.social 🤝 @ipbstoulouse.bsky.social 📕 buff.ly/4R5iaMB ▶️
buff.ly
Tuberculose : comment la bactérie évacue les métaux toxiques pour résister au système immunitaire
Le bacille de la tuberculose survit dans les cellules immunitaires en neutralisant des métaux toxiques comme le zinc.
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Reposted by Pierre Dupuy
The EMBO Journal @embojournal.org · 13/02/2026
How can bacterial pathogens weather metal ion stress during infection? @pierredupuy.bsky.social, @oneyrolles.bsky.social et al implicate ‘effluxosomes’, membrane clusters of metal-binding chaperones & exporters coordinating M. tuberculosis resistance to toxic metals link.springer.com/article/10.1...
link.springer.com
Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal
Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...
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Reposted by Pierre Dupuy
Olivier Neyrolles @oneyrolles.bsky.social · 13/01/2026
🥳 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐥𝐚𝐭𝐞𝐬𝐭 𝐰𝐨𝐫𝐤 𝐬𝐡𝐨𝐰𝐢𝐧𝐠 𝐡𝐨𝐰 𝐩𝐨𝐥𝐲𝐬𝐢𝐚𝐥𝐲𝐥𝐚𝐭𝐢𝐨𝐧, 𝐚 𝐫𝐚𝐫𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐦𝐨𝐝𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧, 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐦𝐨𝐧𝐨𝐜𝐲𝐭𝐞 𝐦𝐨𝐛𝐢𝐥𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐛𝐨𝐧𝐞 𝐦𝐚𝐫𝐫𝐨𝐰. ✍️ Aurélien Boyancé, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social 📖 shorturl.at/IDwza 👇 A short thread...
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Olivier Neyrolles @oneyrolles.bsky.social · 08/01/2026
Nothing like a good meal with an even better team. Here’s to a bright, productive 2026! 🤩 @mcaouaille.bsky.social @saurabhchugh09.bsky.social @vogeleerp.bsky.social @yoannrombouts.bsky.social & more!
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Reposted by Pierre Dupuy
Olivier Neyrolles @oneyrolles.bsky.social · 11/12/2025
🚨 𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐟𝐫𝐨𝐦 𝐨𝐮𝐫 𝐥𝐚𝐛, 𝐚𝐧𝐝 𝐚 𝐟𝐢𝐫𝐬𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐓𝐁 𝐟𝐢𝐞𝐥𝐝! 🚨 We’re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses. 📖 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁: shorturl.at/r5jd9
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Reposted by Pierre Dupuy
Olivier Neyrolles @oneyrolles.bsky.social · 23/09/2025
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org! It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance. Huge congrats to Wendy & colleagues! shorturl.at/WbFQC
pnas.org
Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS
Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper under...
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Pierre Dupuy @pierredupuy.bsky.social · 12/06/2025
After a PhD and two postdocs, I’m very proud to be joining the CNRS as a Chargé de recherche, this is a meaningful milestone. Huge thanks to Claude Bruand, @michaelglickman.bsky.social, and @oneyrolles.bsky.social for their guidance and support. Olivier, let’s turn this into exciting discoveries!
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Reposted by Pierre Dupuy
Michael Glickman @michaelglickman.bsky.social · 25/03/2025
Pleased to highlight a new preprint from the lab. This is the work of my longtime collaborator in the lab Allison Fay, who wanated to create new tools for disocvery biology in mycobacteria, specifically a new sysem for protein localizaton and proximity proteomics. www.biorxiv.org/content/10.1...
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Reposted by Pierre Dupuy
Olivier Neyrolles @oneyrolles.bsky.social · 27/03/2025
Shout-out to @pierredupuy.bsky.social and colleagues! Excited to share our latest study, where we uncovered a previously unknown bacterial defense system in M. #tuberculosis: effluxosomes — dynamic membrane clusters that coordinate resistance to multiple toxic metals. shorturl.at/Ek0HD #MicroSky
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IPBS Toulouse @ipbstoulouse.bsky.social · 25/03/2025
Comment la bactérie responsable de la tuberculose survit-elle aux attaques des cellules immunitaires ? 🦠 Pierre Dupuy, lauréat d’une bourse postdoctorale Marie-Curie financée par l’UE, revient sur son projet. @cnrsbiologie.bsky.social @cnrs.fr @isabellesaves.bsky.social @oneyrolles.bsky.social
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Reposted by Pierre Dupuy
Olivier Neyrolles @oneyrolles.bsky.social · 13/03/2025
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues! We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell. Let's dive in👇 shorturl.at/x4Sb5
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