Nature Microbiology - Whole-organism malaria vaccine efficacy relies on host cell traversal by Plasmodium parasites, which promotes protective liver-resident CD8 T cell responses independently of...

Clostridioides difficile causes severe disease in adults but commonly colonizes infants asymptomatically. The consequences of early-life colonization on host development remain unknown. In a neonatal ...

Intramuscular administration of vitamin K for prevention of vitamin K deficiency bleeding (VKDB) has been a standard of care since the American Academy of Pediatrics recommended it in 1961. Despite th...

Personal stories from families affected by vitamin K deficiency bleeding.

Vitamin K lowers the risk of bleeding, including in a circumcision. That procedure may explain a disparity in which infants are more likely to get the shot.

OBJECTIVES. The risk of persistent multisystem dysfunction following multisystem inflammatory syndrome in children (MIS-C), a severe postviral complication of COVID-19, remains unknown.METHODS. We inv...

The agency’s analysis contradicts claims made by former vaccine chief Dr. Vinay Prasad.

How pandemic trauma reshaped the way we think about infectious threats

10.1542/6390324821112Video AbstractPEDS-VA_2025-0735566390324821112OBJECTIVES. This study set out to describe imported pediatric malaria in the United States over an 8-year period, including patient demographics, clinical outcomes, and risk factors for severe disease.METHODS. A retrospective descriptive study of pediatric patients treated for malaria at 9 hospitals in the United States from 2016 to 2023 was conducted to analyze patient demographics, clinical outcomes, and risk factors for severe malaria.RESULTS. A total of 171 children were treated across the 9 US hospitals included in this study from 2016 to 2023. Most patients had traveled to West Africa to visit friends and relatives. Fever was the most common symptom recorded (90%), and most reported at least 1 abdominal symptom (66%). Thirty-two percent of patients were diagnosed with severe malaria. No deaths occurred. Delayed diagnoses were common (26%), occurred at similar rates across all hospitals in the study, and were a risk factor for severe malaria.CONCLUSIONS. Delayed diagnoses of travel-acquired malaria were common for pediatric patients presenting to hospitals in the United States and are associated with higher risk for severe malaria, which is associated with longer hospitalizations and increased morbidity. Chemoprophylaxis against travel-acquired malaria and prompt diagnosis of imported cases are crucial to improving patient outcomes.

Children who had cerebral malaria or severe malaria anemia have lower scores on tests measuring general cognition and math achievement

A new study shows that strain-level surveillance of Staphylococcus aureus in NICUs can identify hidden transmission pathways and enable targeted interventions to reduce serious infections in vulnerabl...

How Philly's leading vaccine doctor became MAHA's public enemy number one

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Update of NIH Late Application Submission Policy and End of Continuous Submission NOT-OD-26-064. NIH

Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual&nbsp...

The recall follows complaints of a “gel-like mass and black particles in the product.”