The aging field needs to develop reliable biomarkers of aging and a solid evidence base for the safety and efficacy of anti-aging treatments.

Axons require intracellular transport of cargoes between the soma and the terminus. The authors show a related logistical challenge exists at smaller scale with respect to the interaction of process-b...

Shifting the focus of equity initiatives from identity categories to structural barriers can reveal overlooked challenges and increase global support.

The organisation of myelinated axons into specialised domains is essential for saltatory conduction and depends on the polarised distribution of neuronal and glial cell-adhesion molecules, including n...

Welcome to preLights, the preprint highlights service run by the biological community and supported by The Company of Biologists. Here, a team of scientists regularly review, highlight and comment on ...

Metabolic determinants of white matter integrity remain elusive. Here, the authors show downregulation of MCT2 in oligodendrocytes in progressive MS, and then demonstrate its role in myelin maintenanc...

Un agent administratif du CNRS a été condamné à dix-huit mois de prison, mardi 9 juin, pour des faits de voyeurisme à caractère sexuel à l’encontre de dizaines de scientifiques d’un laboratoire de rec...

May 29, 2026      -     FMUL, Lisboa

A transient grey matter microgliosis is required for remyelination, the failure of which results in a chronic neuroinflammatory state seen in neurodegenerative disorders.

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Single-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that may shape repair p...

Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...

CDC42-effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin-dependent scaffolding of myelin. Myelin o...

Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...

The microtubule cytoskeleton is the backbone of neuronal morphogenesis, driving the development of the dendrites and axon, and supporting trafficking to distant compartments. How neuronal microtubules...

Cuprizone demyelination induces transient reactive states in deep cortical microglia (MG) through early recovery. Depleting MG in recovery increases the number of deep cortical mature/pre-myelina...

"Au regard de leur exercice comptable de 2023, 29 720 sociétés déclarent 27 Md€ de dépenses éligibles au CIR, […] générant un crédit d’impôt de 7,8 Md€...

Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...

We recognize the outstanding achievements of 25 neuroscientists who stand to shape the field for years to come.

INTRODUCTION The ε4 allele of the apolipoprotein E (APOE) gene is a risk factor for the development of Alzheimer's disease (AD). APOE4 isoform is associated with increased white matter lesions in hu.....

Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.

The GCC organizing committee is committed to supporting our community by helping reconcile professional and personal lives, especially for parents of young children. We are therefore working to provid...