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Michael Deghelt

@michaeldeghelt.bsky.social

231 followers 145 following 4 posts

Microbiologist

Michael Deghelt @michaeldeghelt.bsky.social · 13/11/2025

The diderm cell envelope is not a stack of layers but a unified scaffold of Inner Membrane–Peptidoglycan–Outer Membrane. We discuss how tethering the OM to the PG in E. coli preserves integrity — and extend the concept across diderm bacteria. Curr Opin Microbiol: doi.org/10.1016/j.mi... #microsky 🔬

doi.org

Redirecting

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Michael Deghelt @michaeldeghelt.bsky.social · 31/07/2025

Most stories don’t really start the way we write them in papers—and ours is no exception. To find out how it really began with a simple PCR trick, check out our Behind the Paper: « Out Of The Blue, It Came To Me » 👉 communities.springernature.com/posts/out-of... #MicroSky

communities.springernature.com

Out Of The Blue, It Came To Me

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Michael Deghelt @michaeldeghelt.bsky.social · 29/07/2025

#microsky We challenge the long-standing view that peptidoglycan alone protects cells from bursting. Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria. 📄 www.nature.com/articles/s41...

nature.com

Peptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria - Nature Microbiology

Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.

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