iiinova — where your digital self keeps evolving

Yilei Fu @yileifu.bsky.social · 24/10/2025

We introduce trio-barcoded @nanoporetech.com adaptive sampling (TBAS), which allows targeted sequencing of one trio in one flowcell. We tested it on HG002-4+13 trios from GREGoR. TBAS and pipeline accurately report causative SNV, SV&TRs. @sedlazeck.bsky.social www.medrxiv.org/content/10.1...

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Reposted by Yilei Fu

smahtnetwrk.bsky.social @smahtnetwrk.bsky.social · 03/07/2025

The SMaHT marker paper is now live in @nature.com 🧬 This landmark study characterizes somatic variation across 19 tissue types from 150 nondiseased donors, laying the groundwork for future discoveries in health, aging, and disease. Read the full paper: www.nature.com/articles/s41...

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Reposted by Yilei Fu

Fritz Sedlazeck @sedlazeck.bsky.social · 03/04/2025

Long reads such as @nanoporetech.com or @pacbio.bsky.social can provide insights into epigenetic. We @yileifu.bsky.social & @timp0.bsky.social )summarize the latest #Bioinformatics approaches & why this matters! Out now @natrevgenet.bsky.social at: bit.ly/4cjxUtl @bcmhouston.bsky.social @jhu.edu

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Yilei Fu @yileifu.bsky.social · 29/03/2025

We summarized state-of-the-art computational methods for DNA methylation analysis using long-read sequencing, covering everything from base calling to sample-level, cell-type-level, and even population-scale analysis. Huge thanks to @sedlazeck.bsky.social and @timp0.bsky.social for this great work!

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Reposted by Yilei Fu

Fritz Sedlazeck @sedlazeck.bsky.social · 29/04/2024

Had a great lab retreat on Saturday at rice together with @svillapol.bsky.social and @treangen.bsky.social lab. Amazing talks, discussions and overlap of interests. Won't be the last one :)

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Yilei Fu @yileifu.bsky.social · 28/11/2023

Great day in my life!! Finally defended my Ph.D.! I can’t do this without the guidance of my Ph.D. advisor @treangen.bsky.social and my co-advisor @sedlazeck.bsky.social ! I’ll soon join @sedlazeck.bsky.social ’s group at as an postdoc focusing on cancer genetics and cancer epigenetics.

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