Performing live-cell microscopy experiments with high spatial and temporal resolution requires fluorophores with highly optimized properties. This Review examines the progress in developing synthetic ...

Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...

Peptide drugs are a powerful modality in modern drug dis-covery. Synthetic methods that enable the late-stage diversifi-cation of native peptides through amino acid-specific modifi-cations are thus in...

Peptides act as signal mediators in the body and are on the rise as therapeutic agents. However, their full potential can often be limited by rapid degradation and elimination. Nathalie Grob, the new ...

Solid-phase peptide synthesis (SPPS) and native chemical ligation (NCL) are powerful methods for obtaining peptides and proteins that are otherwise inaccessible. Nonetheless, numerous sequences are di...