iiinova — where your digital self keeps evolving

Reposted by Mike Cohen

Jonathan Pruneda @jnpruneda.bsky.social · 28/04/2026

Registration has been reopened to fill the last few remaining spots! Last chance to join us in Leiden this June!

Reposted by Mike Cohen

Keri Backus @keribackus.bsky.social · 28/04/2026

Super excited that our SEE-CITE photoaffinity labeling method is now out in @natchem.nature.com rdcu.be/ffBSC. Here we introduce a custom silyl ether cleavable linker between a diazirine photocrosslinker handle and molecules of interest to streamline site-of-labeling analysis for PAL chemoproteomics

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Reposted by Mike Cohen

Luke Lavis @rhodamine110.bsky.social · 24/03/2026

The best two years you can spend before graduate school! Get the hands of a 4th-year grad student contributing to Open Science: bit.ly/47mU5xx Or join an interdisciplinary AI/biology team (don't worry, the AI still needs you to do the actual experiments): bit.ly/4taqzni Both at Janelia!

bit.ly

Research Technician - Tool Translation Team

Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. Summary: We are seeking a chemist to join the Tool Translation Team, "...

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Reposted by Mike Cohen

Joshua Saldivar @saldivar-lab.bsky.social · 04/02/2026

I am excited to share the first paper from the Saldivar lab! A special thank you to all who contributed. Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...

cell.com

Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability

Marmolejo et al. uncover transcription condensate dynamics at histone locus bodies across the cell cycle. These dynamics are governed by cell cycle (DDK and CDK1/2) and checkpoint (ATR-CHK1) kinases t...

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Mike Cohen @michaelnadbio.bsky.social · 03/02/2026

Congrats Karolin for this well deserved award!

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Reposted by Mike Cohen

Zha Lab @zhalab.bsky.social · 21/01/2026

Registration deadline extended to January 31, 2026. Join us @nucleosomepolice.bsky.social @leunglab.bsky.social at CSHL for the PARP Meeting—connect with leaders and rising stars from academia and industry. Please kindly repost! .https://meetings.cshl.edu/meetings.aspx?meet=parp

meetings.cshl.edu

The PARP Family & ADP-ribosylation

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

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Mike Cohen @michaelnadbio.bsky.social · 21/01/2026

Did you miss the original abstract deadline? No worries, we’ve extended it to January 30th! Don’t miss your chance to be part of an exciting meeting highlighting the cutting edge of the field.

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Mike Cohen @michaelnadbio.bsky.social · 15/01/2026

Just two more days to submit abstracts for the "PARP Family and ADP-ribosylation CSHL meeting. We have an amazing lineup of speakers. The majority of speakers are selected from abstracts. Don't miss out! meetings.cshl.edu/meetings.asp...

meetings.cshl.edu

The PARP Family & ADP-ribosylation

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

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Mike Cohen @michaelnadbio.bsky.social · 06/01/2026

very cool, team Balyn-congrats!

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Reposted by Mike Cohen

Balyn Zaro @balynzaro.bsky.social · 06/01/2026

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines. www.biorxiv.org/content/10.6...

biorxiv.org

Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines

Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...

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Mike Cohen @michaelnadbio.bsky.social · 07/12/2025

Looking forward to the biannual #CBP2025 conference @ohsunews.bsky.social starting this week! incredible line up of speakers, including keynotes @mbogyo.bsky.social, @christhechang.bsky.social, and Nancy Carrasco. www.ohsu.edu/school-of-me...

ohsu.edu

Chemical Biology and Physiology 2025 | OHSU

Chemical Biology and Physiology Conference 2025, December 11-13, 2025

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Mike Cohen @michaelnadbio.bsky.social · 02/12/2025

Excellent study by first author @andriigorelik.bsky.social in @ahellab.bsky.social showing how DTX2 tunes AHR transcription and stability, offering deeper insight into ADP-ribosylation–ubiquitylation crosstalk.

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Mike Cohen @michaelnadbio.bsky.social · 13/11/2025

Happy to have made a small contribution during my mini-sabbatical in @ladurner.bsky.social lab!

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Mike Cohen @michaelnadbio.bsky.social · 13/11/2025

They demonstrate that a common PARP1 variant (V762) shifts talazoparib from a non-retentive (Type II) to an allosteric, pro-retention (Type I) mode, thereby boosting chromatin trapping and cancer cell killing. The finding makes a strong case for genotype-guided dosing in HRD cancer therapy.

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Mike Cohen @michaelnadbio.bsky.social · 13/11/2025

Talazoparib stands out for its strong potency and DNA "trapping" in certain cancers, but why this happens wasn’t clear. A new preprint from first author Jin Cai in the @ladurner.bsky.social lab, together with Ben Black’s team, address this in a new preprint: www.biorxiv.org/content/10.1...

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Mike Cohen @michaelnadbio.bsky.social · 11/11/2025

Agreed! This review thoughtfully and comprehensively dives into the world of HPF1. The questions at the end are on point!

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Reposted by Mike Cohen

Jeremy Berg @jeremymberg.bsky.social · 17/07/2025

My quote of the day A Video Quote Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble. (From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)

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Reposted by Mike Cohen

Thiago Carvalho @cyrilpedia.bsky.social · 13/07/2025

'Particularly at risk is the category of basic research — the blue-sky variety meant to push back the frontiers of human knowledge and sow practical spinoffs and breakthroughs in such everyday fields as health care and artificial intelligence.' www.nytimes.com/2025/07/10/s...

nytimes.com

Trump Seeks to Cut Basic Scientific Research by Roughly One-Third, Report Shows

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Reposted by Mike Cohen

ahellab.bsky.social @ahellab.bsky.social · 10/07/2025

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114! www.nature.com/articles/s41... www.science.org/doi/10.1126/...

nature.com

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications

Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

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Reposted by Mike Cohen

Andrii Gorelik @andriigorelik.bsky.social · 10/07/2025

An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story

nature.com

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications

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Mike Cohen @michaelnadbio.bsky.social · 10/07/2025

Congrats Jeremy! Well-deserved!

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Mike Cohen @michaelnadbio.bsky.social · 09/07/2025

Exciting times in the fields of ADP-ribosylation and ubiquitylation!

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Mike Cohen @michaelnadbio.bsky.social · 09/07/2025

This paper, coupled with an exciting new paper from @ahellab.bsky.social and the Van Der Heiden Van Noort groups: www.nature.com/articles/s41... And our recent collaborative work with @jnpruneda.bsky.social team: www.biorxiv.org/content/10.1... reveal RNF114 as a reader and writer of MARUbylation.

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Mike Cohen @michaelnadbio.bsky.social · 09/07/2025

Cool new paper from Matic lab showing that MARUbylation occurs on serines in response to DNA damage.

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Mike Cohen @michaelnadbio.bsky.social · 07/07/2025

Check out this story about my OHSU colleague’s work describing a previously unknown critical neurological function for dystroglycan with important implication for neuromuscular disease.

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Mike Cohen @michaelnadbio.bsky.social · 03/07/2025

Check out this great review on the fascinating field of renal interoception by our newest faculty member, @rose-hill.bsky.social!

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Mike Cohen @michaelnadbio.bsky.social · 25/06/2025

Very cool finding, Matt. Congrats!

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Reposted by Mike Cohen

Pete Buttigieg @petebuttigieg.bsky.social · 12/06/2025

Today they have crossed a deep red line. We, the people, must hold the president and his appointees accountable for this outrageous abuse against American liberty.

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Mike Cohen @michaelnadbio.bsky.social · 12/06/2025

Excellent paper by first author @andriigorelik.bsky.social and @ahellab.bsky.social team that uncovers new insights into PARP7-AHR biology in PARP7i-sensitive cancer cells.

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Reposted by Mike Cohen

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 09/06/2025

Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸

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Mike Cohen @michaelnadbio.bsky.social · 08/06/2025

😂. Hopefully Proctor’s gym has been upgraded to include a post-game recovery room, with cold baths and compression gear-haha. Every time I go out and play my body’s reminding me I’m not 25 anymore!

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Mike Cohen @michaelnadbio.bsky.social · 08/06/2025

@doc-jlmeier.bsky.social got my swag, and now I’m ready for some good science and basketball at the #2025BioorganicGRC. It’s been too long!

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Reposted by Mike Cohen

Jonathan Pruneda @jnpruneda.bsky.social · 08/06/2025

Lots of exciting work to do at this interface between #ubiquitin and #ADP-ribosylation! In the coming months, @michaelnadbio.bsky.social and I hope to be recruiting new team members to explore this space. Here is a thread of other exciting opportunities to check out!

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Mike Cohen @michaelnadbio.bsky.social · 08/06/2025

Yeah, this was definitely a major milestone for her. Amazing come from behind victory!

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Mike Cohen @michaelnadbio.bsky.social · 05/06/2025

Cool new manuscript by @tafesselab.bsky.social and colleagues revealing a fascinating connection between SARS-CoV-2 infection and host lipid metabolism. Perhaps this opens up new therapeutic opportunities? Congrats!

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Reposted by Mike Cohen

ahellab.bsky.social @ahellab.bsky.social · 24/05/2025

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...

my.corehr.com

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Mike Cohen @michaelnadbio.bsky.social · 03/06/2025

Awesome review by Braden Lobingier and colleagues on ways to study compartmentalized GPCR signaling.

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Reposted by Mike Cohen

Karolin Luger @nucleosomepolice.bsky.social · 29/05/2025

I have had the privilege to train many chinese students over many years. They enriched our lives and did great science. Many are still here and contribute to the US scientific enterprise. The push to revoke student visas is cruel and unnecessary. We must push back. www.npr.org/2025/05/28/g...

npr.org

Rubio says U.S. will 'aggressively' revoke visas for many Chinese students

The announcement to revoke visas is the most drastic move yet to curtail the numbers of international students studying in the U.S.

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Mike Cohen @michaelnadbio.bsky.social · 27/05/2025

🤪 yikes! Hope this is the worst of it.

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Mike Cohen @michaelnadbio.bsky.social · 25/05/2025

This is a profound loss for the scientific community.

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Mike Cohen @michaelnadbio.bsky.social · 23/05/2025

Congrats! This is an amazing milestone, Matt.

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