PARP4 is an ADP-ribosyltransferase typically associated with the cytoplasmic vault organelle. PARP4 has a distinct domain composition relative to other PARP enzymes; however, the N-terminal region of ...

Langelier et al. discover that PARP1, PARP2, and Tankyrase catalyze de novo synthesis of protein-free poly(ADP-ribose), or PAR, in addition to canonical protein-linked PAR. Cellular free PAR did not r...