Nature Reviews Gastroenterology & Hepatology - Pancreatic development is a dynamic process. This Review discusses the development and cellular plasticity that occurs in the pancreas in health...

By mapping chromatin accessibility over transposable elements (TEs) across normal hematopoietic cells and the various cell types of primary acute myeloid leukemia (AML), we identified TE subfamilies w...

The Department of Biology conducts research and teaching in many subject areas such as ecology, evolutionary biology, organismal biology and molecular biology. A total of approximately 300 people curr

This project will investigate gene regulatory networks controlled by primate-specific transposable elements responsive to inflammation and DNA damage and probe how they are disrupted in cancer.

Here, we present a workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). We describe steps for designing guide RNAs (gRNAs) to target ...

LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...

This Perspective explores the co-evolution of transposable elements and KRAB zinc-finger proteins in relation to their integration into human gene regulatory networks, highlighting their potential eff...