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ASAP Team Jakobsson

@jakobssonasap.bsky.social
215 followers 294 following 15 posts

ASAP Team Jakobsson is interested in studying the role of transposable elements in Parkinson's disease pathogenesis | Core leadership: Johan Jakobsson (LU), Agnete Kirkeby (UCPH), Molly Gale Hammell (NYU) & Roger Barker (Cambridge University)

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Reposted by ASAP Team Jakobsson
The Barker Lab @thebarkerlabgroup.bsky.social · 28/04/2026
Excited to share that our team is joining ASAP CRN @asapresearch.parkinsonsroadmap.org! We look forward to collaborating with scientists globally to catalyze breakthroughs in Parkinson’s & accelerate discoveries that lead to new treatments. Explore more: asapcrn.org #ParkinsonsDisease
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 02/03/2026
Are you interested in achieving efficient silencing of transposable elements using CRISPRi? 🧬 🧫 Go ahead and have a look at this STAR protocols where Adami et al. share all the tips & tricks they use in the Jakobsson lab. @anitaada.bsky.social @raquelgarza.bsky.social @jakobssonlab.bsky.social
cell.com
Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
Here, we present a workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). We describe steps for designing guide RNAs (gRNAs) to target ...
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Reposted by ASAP Team Jakobsson
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 12/01/2026
CRN Teams Cragg & Jakobsson's new #preprint maps the cell-type–specific transcriptional landscape of the parkinsonian striatum in mouse models and human Parkinson's stages, revealing widespread gene expression changes and resilient neuron subtypes amid progressive dopamine loss 🧪 🔗 bit.ly/4ju4MmS
Single-cell atlas of striatal cells from early-stage Parkinson's mouse models and Parkinson's patients.
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 01/12/2025
Have a look at two of the latest outputs from CRN Team Jakobsson, examples of true team effort and collaboration 🧠 💫 We are grateful to @asapresearch.parkinsonsroadmap.org for making this research possible! @jakobssonlab.bsky.social @kirkebylab.bsky.social @mollygale.bsky.social #RogerBarkerLab
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Reposted by ASAP Team Jakobsson
Kunath Lab @kunathlab.bsky.social · 01/12/2025
Agnete Kirkeby’s 2025 Edinburgh Parkinson’s Lecture is available online: youtu.be/EtuRHdPX4rc?... She delivered a masterclass on stem cell therapies for #Parkinsons. A PwP told me : “I was expecting not to understand much, but I understood everything!” @kirkebylab.bsky.social @parkinsons.org.uk
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Reposted by ASAP Team Jakobsson
Raquel Garza @raquelgarza.bsky.social · 07/11/2025
Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠 #ASAP @jakobssonasap.bsky.social
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 29/10/2025
📣 New preprint from the Jakobsson lab! We describe a detailed protocol to inhibit the expression of transposable elements in human pluripotent stem cells, developed thanks to @asapresearch.parkinsonsroadmap.org funding. Special shoutout to @anitaada.bsky.social! www.biorxiv.org/content/10.1...
biorxiv.org
A framework for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
This protocol describes the workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). The protocol illustrates how to design gRNAs to targ...
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 23/10/2025
@raquelgarza.bsky.social from the Jakobsson Lab presented our recent work on single-cell omics (transcriptomics+ proteomics) within our ASAP project at the SciLifeLab Lund day. This work is being done in collaboration with #BioMS and @scilifelab.se. We are looking forward to the discoveries ahead 🌟
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 17/09/2025
Have a look at the new preprint from Team Cragg! We are very happy of having contributed to this great work as a collaboration within the ASAP-CRN network 🧠🔬 @craggasap.bsky.social @asapresearch.parkinsonsroadmap.org
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 09/09/2025
🚨 Have a look at our new preprint: www.biorxiv.org/content/10.1... A highly collaborative effort where we show that transposable elements are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease. @asapresearch.parkinsonsroadmap.org
biorxiv.org
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
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Reposted by ASAP Team Jakobsson
Lund Stem Cell Center @lundstem.bsky.social · 28/08/2025
🧬 🧠A new Cell Genomics study by researchers at @lunduniversity.bsky.social (@jakobssonlab.bsky.social & @jakobssonasap.bsky.social) shows the non-coding genome is active in early brain development & may be relevant for understanding brain disease. Read more: www.stemcellcenter.lu.se/article/why-...
stemcellcenter.lu.se
Why repetitive DNA matters for human brain evolution and disease
Lund University. DNA carries the complete set of instructions an organism needs to develop and survive, but only about 1.5% of it consists of protein-coding genes that determine traits such as eye col...
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 27/08/2025
Team Jakobsson gathered in southern Sweden for a few inspiring days discussing PD, transposable elements and future plans. We even squeezed in a hike and enjoyed some beautiful views ☀️🌊 @jakobssonlab.bsky.social @kirkebylab.bsky.social @mollygale.bsky.social @asapresearch.parkinsonsroadmap.org
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Reposted by ASAP Team Jakobsson
Raquel Garza @raquelgarza.bsky.social · 09/07/2025
These past 2 months as a visiting scholar at KU Leuven flew by! It has been so enriching to work side by side with #TeamVoet on @jakobssonasap.bsky.social research into Transposable Elements & Parkinson’s Disease 🧠🧬 Excited for what’s next! #ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 18/03/2025
Last week, some of us from Team Jakobsson had a great time in Arizona at the 2025 CRN Collaborative Meeting! Plenty of insightful talks and networking. Shoutout to @kirkebylab.bsky.social for a fantastic talk on PSC-based therapies and models of PD 🌟🧬🏜️ #CRNPhoenix2025 @asapresearch.bsky.social
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Reposted by ASAP Team Jakobsson
Raquel Garza @raquelgarza.bsky.social · 12/03/2025
Popcorn worthy research at #CRNPhoenix2025 with @jakobssonasap.bsky.social 🍿 #ParkinsonsDisease #PD #TEsky
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 20/01/2025
🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 18/01/2025
🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development. This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab. www.biorxiv.org/content/10.1...
biorxiv.org
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 10/12/2024
🌟🧠🧬 Exciting meetup in Cambridge with the Barker, Jones and Jakobsson labs! Great discussions, fresh ideas, and plenty of plans for the next steps. @asapresearch.bsky.social @jakobssonlab.bsky.social
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 05/12/2024
We're thrilled to announce that our project has been funded by @asapresearch.bsky.social in partnership with the Michael J. Fox Foundation! 🚀 Excited to continue exploring the role of transposable elements in Parkinson’s disease. Learn more here: www.lunduniversity.lu.se/article/52-m...
lunduniversity.lu.se
52 Million SEK towards uncovering genetic drivers of Parkinson’s Disease
Lund University. Jumping genes, or transposable elements, make up nearly half of the human genome. These mobile sequences can shift within the genome and are known to influence various biological proc...
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