iiinova — where your digital self keeps evolving

Reposted by Anita Adami

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 07/09/2025

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease www.biorxiv.org/content/10.1101/202…

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Anita Adami @anitaada.bsky.social · 03/09/2025

Whoop whoop 🥳 it always feels great to celebrate achievements throughout one's scientific journey! Thanks again to everyone who has been involved, has showed up to cheer with us, and appreciated our latest work on Cell Genomics www.cell.com/cell-genomic...

cell.com

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development

Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of L1s...

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Reposted by Anita Adami

Raquel Garza @raquelgarza.bsky.social · 24/08/2025

Excited to share our latest work!! 🌟🌟 Thank you for all the amazing work and congratulations to @anitaada.bsky.social and all the coauthors! 🍾

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Anita Adami @anitaada.bsky.social · 24/08/2025

I'm so happy and excited to be sharing this! Feeling deeply grateful for all the collaborative effort that went into the project and very proud of this work. 🧬🧠

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Anita Adami @anitaada.bsky.social · 11/06/2025

I'm so excited and honoured to share our research!! 💡

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Reposted by Anita Adami

Christopher Douse @chdouse.bsky.social · 17/04/2025

Come to Lund! We are looking for a postdoc to join the team. #transposons #epigenetics

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Anita Adami @anitaada.bsky.social · 18/04/2025

Beyond excited to share that I have received a Travel and Merit Award for the ISSCR 2025 Annual Meeting in Hong Kong. I will present our latest work on the role of LINE-1s in human pluripotency and early brain development (preprint alert: doi.org/10.1101/2025...). I hope to see you there! 🌺

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Reposted by Anita Adami

Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 26/02/2025

In this paper, CRN Team @jacksonlab.bsky.social found that LINE-1 transposable elements contribute to the complexity of the transcriptome in human pluripotent stem cells by acting as alternative promoters for approximately 100 genes. Check out the full #preprint: shorturl.at/TJ9BK

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Reposted by Anita Adami

Geoff Faulkner @faulknerlab.bsky.social · 13/02/2025

Read this preprint today from @jakobssonlab.bsky.social lab that profiles and CRISPRi perturbs L1 transcription in hiPSCs and cerebral organoids. It is extremely well done. The L1 CRISPRi phenotype in the organoids is subtle and variable but interesting. 1/n www.biorxiv.org/content/10.1... #TEsky

biorxiv.org

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...

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Reposted by Anita Adami

ASAP Team Jakobsson @jakobssonasap.bsky.social · 20/01/2025

🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social

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Reposted by Anita Adami

Raquel Garza @raquelgarza.bsky.social · 18/01/2025

We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾 #TEsky #CRISPR #L1 #development #epigenetics

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Anita Adami @anitaada.bsky.social · 18/01/2025

Profiling and targeting young L1s is no easy matter 🧐 check out our new preprint to see how we delve into transcriptional and epigenomic profiling of L1s, and investigate their involvement in pluripotency and early brain development 🧠

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Anita Adami @anitaada.bsky.social · 18/01/2025

Hello bluesky! Way to kick off 2025! Thanks to everyone involved 🚀

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Reposted by Anita Adami

ASAP Team Jakobsson @jakobssonasap.bsky.social · 10/12/2024

🌟🧠🧬 Exciting meetup in Cambridge with the Barker, Jones and Jakobsson labs! Great discussions, fresh ideas, and plenty of plans for the next steps. @asapresearch.bsky.social @jakobssonlab.bsky.social

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