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Claudia Alen Amaro @claudialen.bsky.social · 28/05/2026

The @instruct-eric.bsky.social Biennial Structural Biology Conference #IBSBC2026 is underway today in Brussels Thanks to our hosts @jansteyaert.bsky.social and his team at the highly successful #Nanobodies4Instruct facility Learn all about is and apply to access instruct-eric.org

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Bijvoet Centre @bijvoet-centre.bsky.social · 11/05/2026

We are excited to be at our annual Bijvoet Symposium today, for a day filled with exciting structural biology presented by our PhD students and postdocs!

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Bijvoet Centre @bijvoet-centre.bsky.social · 13/04/2026

Today we celebrated, in the presence of the Dutch minister of Education, Culture and Science, Rianne Letschert, the NWO Roadmap grants, including the BioBeyond_NL and EMPower grants investing in infrastructures for biology beyond the genome and for electron microscopy in the Netherlands!

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Bijvoet Centre @bijvoet-centre.bsky.social · 19/03/2026

We are happy to be hosting Sander van Kasteren, of Leiden University, @unileiden.bsky.social, for a Bijvoet Seminar! Sander combines organic synthesis (click chemistry) and dendritic cell biology to study and manipulate the uptake and routing of antigens in dendritic cells.

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Mohammed AlQuraishi @moalquraishi.bsky.social · 13/03/2026

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

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Bijvoet Centre @bijvoet-centre.bsky.social · 19/02/2026

We are happy to be hosting John Christodoulou, of University College London, @ucl.ac.uk, today for a Bijvoet Seminar entitled "Structural investigations of protein folding on the ribosome".

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Bijvoet Centre @bijvoet-centre.bsky.social · 17/02/2026

With sadness we share the passing of em. prof. dr. Hans Vliegenthart, founder of the Bijvoet Centre for Biomolecular Research at Utrecht University. His scientific legacy will continue to inspire. In memoriam: www.uu.nl/en/news/in-m...

uu.nl

In memoriam: Hans Vliegenthart

In memoriam: prof. dr. Hans Vliegenthart (April 7, 1936 – February 12, 2026)

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Bijvoet Centre @bijvoet-centre.bsky.social · 15/01/2026

We are happy to be hosting David Dulin, @dulinlab.bsky.social, of @vuamsterdam.bsky.social today, for a Bijvoet Seminar entitled "Leveraging high-throughput magnetic tweezers to investigate coronavirus replication at the single-molecule level".

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Bijvoet Centre @bijvoet-centre.bsky.social · 16/10/2025

We are happy to be hosting Alex Volkov of the Vrije Universiteit Brussel today, for a Bijvoet Seminar entitled "When chemistry meets biology: a travel to the protein multiverse".

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Bijvoet Centre @bijvoet-centre.bsky.social · 04/07/2025

Today, the Dutch nodes of the European Life and Medical Science Research Infrastructures discuss their strategy and sustainability for the future at @naturalis.bsky.social in Leiden. We are representing @instruct-eric.bsky.social and structural biology.

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Ezgi Karaca @ezgikaraca.bsky.social · 11/06/2025

Only a few days left to apply for our EMBO course with a great lineup of speakers and tutors! Please feel free to RT! Course website: meetings.embo.org/event/25-bio... Organizers: myself, @amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social Location: www.ibg.edu.tr

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Bijvoet Centre @bijvoet-centre.bsky.social · 11/06/2025

Automated detection of macromolecules in cryo-ET data of cellular samples is challenging. Here, we introduce "pytom-match-pick", a GPU-accelerated, open-source interface that improves the efficiency and accuracy of macromolecule detection in cellular contexts: www.sciencedirect.com/science/arti...

sciencedirect.com

pytom-match-pick: A tophat-transform constraint for automated classification in template matching

Template matching (TM) in cryo-electron tomography (cryo-ET) enables in situ detection and localization of known macromolecules. However, TM faces cha…

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Bijvoet Centre @bijvoet-centre.bsky.social · 10/06/2025

The artists from Sensu have worked with @thermofishersci.bsky.social and made this beautiful video on the applications of structural biology: www.youtube.com/watch?v=m3QA... Check out our YouTube channel for videos we made with Sensu about our work: www.youtube.com/@BijvoetCenter

youtube.com

Launching Thermo Fisher Scientific's Krios 5 Cryo-TEM | A New Era in Electron Microscopy

YouTube video by Sensu

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Eva Bertosin @thedneva.bsky.social · 13/05/2025

Indeed I'm happy to be here! Looking forward to great science 💪🏼

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Bijvoet Centre @bijvoet-centre.bsky.social · 14/05/2025

We are happy to host, on behalf of the Netherlands, the Council meeting of Instruct-ERIC (@instruct-eric.bsky.social), the European Research Infrastructure Consortium for structural biology. If you are interested in accessing state of the art structural biology technology, see instruct-eric.org.

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Bijvoet Centre @bijvoet-centre.bsky.social · 13/05/2025

We are very happy to have Christoph Müller from the EMBL (@embl.org) as the final speaker of the joint session of Instruct-ERIC (@instruct-eric.bsky.social) and the Bijvoet Centre at the 2025 Bijvoet Symposium!

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Claudia Alen Amaro @claudialen.bsky.social · 13/05/2025

Delighted to be in Utrecht to learn from our users in the Netherlands, we can always do better!! @utrechtuniversity.bsky.social @nkinl.bsky.social @necen.bsky.social

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Instruct-ERIC @instruct-eric.bsky.social · 13/05/2025

The next speaker this afternoon is Michael Leung of @hubrechtinstitute.bsky.social, who conducted Cryo-EM studies at NeCEN in @unileiden.bsky.social through Instruct! instruct-eric.org/centre/necen...

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Bijvoet Centre @bijvoet-centre.bsky.social · 12/05/2025

Since this month, Eva Bertosin (@thedneva.bsky.social) has joined the Bijvoet Centre, bringing her expertise on biophysics and DNA origami. Welcome Eva!

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Bijvoet Centre @bijvoet-centre.bsky.social · 12/05/2025

Beautiful and inspiring talk by Sheena Radford of the @radford-lab.bsky.social at the Astbury Centre for Structural Molecular Biology (@astbury-bsl.bsky.social) from the University of Leeds (@universityofleeds.bsky.social) at our annual Bijvoet Symposium!

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Bijvoet Centre @bijvoet-centre.bsky.social · 12/05/2025

Great to have almost the entire Bijvoet Centre together for our 2025 Bijvoet Symposium! Looking forward to a lot of exciting science!

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Alexandre Bonvin @amjjbonvin.bsky.social · 07/05/2025

The manuscript describing the new modular version of HADDOCK is finally available as a preprint! The result of a team work over several years, supported by @bioexcelcoe.bsky.social @bijvoet-centre.bsky.social @esciencecenter.bsky.social - www.biorxiv.org/content/10.1...

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Joost Snijder @joostsnijder.bsky.social · 29/04/2025

Simultaneous polyclonal antibody sequencing and epitope mapping by cryoEM and mass spec: how far can we go? Check out the final version of our paper in eLife: elifesciences.org/articles/101...

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Bijvoet Centre @bijvoet-centre.bsky.social · 17/04/2025

We are very happy to host Max Bonomi (@bonomimax.bsky.social) from the Institute Pasteur (@pasteur.fr) for a Bijvoet Seminar about structural and dynamic biology with integrative approaches.

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GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 17/04/2025

#GBMLunch on April 23! Speaker: Tzviya Zeev Ben Mordeha @tzviyazbm.bsky.social from @bijvoet-centre.bsky.social Title: Cryo-EM single particle analysis meets cryo-ET at the sperm tail Chair: Cristina Paulino from @uniheidelberg.bsky.social Organized by the GBM Study Group "Structural Biology"

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Ioannis Skalidis @johnskal.bsky.social · 23/03/2025

The first project I worked on, right after joining @bijvoet-centre.bsky.social!

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Reposted by Bijvoet Centre

Albert Heck @hecklab.bsky.social · 21/03/2025

Interested in advanced therapeutics such as mRNA? See the latest work of Evolène Deslignière, doi.org/10.1016/j.om..., in collaboration with Pfizer, using innovative mass spectrometry & photometry @bijvoet-centre.bsky.social to obtain precision measurements on mRNA purity & structural integrity

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Friedrich Förster @fridof.bsky.social · 20/03/2025

And now to something completely different: the response of an anaerobic archaeon to oxidative stress. Tubular nanocompartments encapsulate virus-like particles! Great work by Wenfei Song and many colleagues from @bijvoet-centre.bsky.social and @mib-wur.bsky.social. www.biorxiv.org/content/10.1...

biorxiv.org

Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus

Reactive oxygen species (ROS) pose a significant threat to biological molecules, prompting organisms to develop systems that buffer oxidative stress and contain iron, which otherwise amplifies ROS pro...

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Bijvoet Centre @bijvoet-centre.bsky.social · 20/03/2025

Exciting Bijvoet Seminar by Marie-Eve Aubin-Tam from @tudelft.bsky.social on the engineering of bioinspired and living materials!

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Bijvoet Centre @bijvoet-centre.bsky.social · 06/03/2025

In this recent study, we used liposomes with E. coli lysates to mimic cellular crowding. We were able to achieve physiological macromolecular crowding levels, creating a platform that enables the controlled study of physiological crowding effects. pubs.acs.org/doi/10.1021/...

pubs.acs.org

Liposome-Encapsulated Escherichia coli Lysates to Reconstitute Intracellular Macromolecular Crowding Effects

Intracellular macromolecular crowding impacts biomacromolecule behavior, including oligomerization, phase separation, and diffusion. However, understanding crowding effects in cells is challenging as ...

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Tzviya Zeev-Ben-Mordehai @tzviyazbm.bsky.social · 28/02/2025

I am honoured to receive a Vici grant from the Dutch Research Council to study sperm functional maturition at the female reproductive tract and to study how sperm establish interaction with an egg www.uu.nl/en/news/nine...

uu.nl

Nine Utrecht-based researchers receive Vici-grant

The Dutch Research Council (NWO) has awarded Vici grants to nine Utrecht researchers.

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Bijvoet Centre @bijvoet-centre.bsky.social · 28/02/2025

We are proud to announce that Tzviya Zeev (@tzviyazbm.bsky.social) and Markus Weingarth each have been awarded a prestigious NWO Vici award! Read more here about the research they plan to do with their grants: www.uu.nl/en/news/nine.... Congratulations to both on their achievement!

uu.nl

Nine Utrecht-based researchers receive Vici-grant

The Dutch Research Council (NWO) has awarded Vici grants to nine Utrecht researchers.

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Bijvoet Centre @bijvoet-centre.bsky.social · 27/02/2025

In this collaboration, it is revealed how structural diversity in computationally designed protein assemblies leads to subunit flexibility. Cryo-EM, native mass spectrometry and simulations reveal features of protein assemblies that enable flexibility in design. www.nature.com/articles/s41...

nature.com

Local structural flexibility drives oligomorphism in computationally designed protein assemblies - Nature Structural & Molecular Biology

This study reports unexpected structural diversity in computationally designed protein assemblies due to subunit flexibility. Fixing flexibility in one design restores the intended architecture, sugge...

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Ioannis Skalidis @johnskal.bsky.social · 11/02/2025

I guess I should have posted a bit earlier, but I'm very excited that my #MSCA application got accepted! I'll be working at @fridof.bsky.social lab @utrechtuniversity.bsky.social to develop my #teamtomo skills on my project: Protein ER-ways! Here's to gaining new insights on ER protein biogenesis!

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Albert Heck @hecklab.bsky.social · 02/02/2025

Another successful PhD defense @bijvoet-centre.bsky.social @utrechtuniversity.bsky.social revealing the new world of immunoglobulomics. Congratulation Danique and your paranimfs Tatiana Shamorkina, Sofia Kalaidopoulou Nteak and co-promotor Albert Bondt👌

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Bijvoet Centre @bijvoet-centre.bsky.social · 31/01/2025

Today we celebrated the start of the spinoff company Abvion (www.abvion.bio) from our Biomolecular Mass Spectrometry and Proteomics research group! @hecklab.bsky.social

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Bijvoet Centre @bijvoet-centre.bsky.social · 27/01/2025

In this recent paper, we describe a new site-specific method for kinase inhibitor profiling maps drug binding with amino acid precision. This approach enhances target identification, uncovers off-target effects, and expands kinase coverage. www.sciencedirect.com/science/arti...

sciencedirect.com

Site-Specific Competitive Kinase Inhibitor Target Profiling Using Phosphonate Affinity Tags

Protein kinases are prime targets for drug development due to their involvement in various cancers. However, selective inhibition of kinases, while av…

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Sjors Scheres @sjorsscheres.bsky.social · 27/01/2025

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳 Re-posts appreciated. www.nature.com/naturecareer...

nature.com

Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196

Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK

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Wout Oosterheert @woutoosterheert.bsky.social · 23/01/2025

My first post on this forum! 😄 I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social www.cell.com/trends/cell-... Big thanks to my amazing colleagues in Dortmund

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Joost Snijder @joostsnijder.bsky.social · 20/01/2025

Registration is now open for the 3rd MS+M conference. Very happy to host this edition in Utrecht. We have an exciting program at the intersection of single molecule imaging and mass spec. Registration and details in the link below: msandm2025.org

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Albert Heck @hecklab.bsky.social · 20/01/2025

We are excited to announce that registration for the 3rd MS+M meeting is open. The meeting is in Utrecht (NL) October 1-3, 2025 and co-chaired by @hecklab.bsky.social, Kyle Fort (ThermoFisher), Kelvin Anggara (MPI Stuttgart) and @joostsnijder.bsky.social. See msandm2025.org

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Bijvoet Centre @bijvoet-centre.bsky.social · 20/01/2025

Microtubules are regulated by lattice geometry. Here, using cryo-electron tomography, we reveal that about a quarter have expanded lattices and changed stability. This lattice spacing might guide protein interactions and control microtubule function in cells. rupress.org/jcb/article/...

rupress.org

StableMARK-decorated microtubules in cells have expanded lattices | Journal of Cell Biology | Rockefeller University Press

de Jager et al. show that compacted and expanded microtubule lattice spacings coexist within cells and that microtubules recognized by a marker for stable

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Bijvoet Centre @bijvoet-centre.bsky.social · 15/01/2025

In a recent publication, we describe our discovery that in rheumatoid arthritis, synovial fluid proteome mirrors plasma, including IgG1 antibodies, suggesting proteins pass directly into joints, aiding pathology insights and therapeutic monitoring. www.sciencedirect.com/science/arti...

sciencedirect.com

Multi-tiered proteome analysis displays the hyper-permeability of the rheumatoid synovial compartment for plasma proteins

Rheumatoid arthritis (RA) is characterized by synovial hyperplasia and cartilage/bone destruction. RA affects the synovial joints, the synovial lining…

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Joost Snijder @joostsnijder.bsky.social · 14/01/2025

Just wrapped up a hearing after objecting to a failed grant application. That’s a first. Was very insightful, will find out soon just how big a snowball’s chance in hell really is 😉 Fingers crossed!

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