Systemic diseases Systemic lupus erythematosus (SLE) Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease driven by autoreactive B cells producing antinuclear antibodies (ANA), which form immune complexes, triggering inflammation and organ damage.136,137 Innate immune dysregulation involves excessive type I interferon (IFN) signaling, neutrophil extracellular traps (NETs), and dendritic cell (DC) activation via TLRs, promoting BAFF production and chronic immune activation.138,139,140 Adaptive immune dysfunction includes T-cell abnormalities, leading to aberrant cytokine release and CD40L-mediated B-cell activation, while Treg and Breg impairment disrupts immune tolerance, sustaining autoantibody production and inflammation.137,141,142,143,144 Significant progress has been made in the treatment of SLE over the past few decades; existing treatment options include corticosteroids, antimalarial drugs, immunosuppressants, and biologics. However, these treatments require long-term use, which can have significant side effects, and their effectiveness often diminishes over time.145,146 Current methods for eliminating alloantibodies include plasma exchange, intravenous immunoglobulin, and monoclonal antibodies. However, these approaches cannot eradicate memory B cells or plasma cells, resulting in limited therapeutic efficacy. The demonstrated success of CAR-T cells in B-cell malignancies—where CD19 CAR-T cells have achieved long-term remission in chronic lymphocytic leukemia patients and eliminated tumor cells in acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma-suggests potential applications for systemic lupus...

In a phase 1 trial, inhibition of the Werner syndrome helicase (WRN) enzyme exploits a new synthetic lethal vulnerability in cancers with microsatellite instability, offering a new way to target these tumors beyond immune checkpoint inhibition.

The Hanna H. Gray Fellows Program supports postdoctoral scientists as they launch careers in academic science, equipping them to pursue scientific research at the highest levels and to recruit, mentor...

Nature Biotechnology - FDA approves oncolytic virus

A new generation of RNA therapies delivered by lipid nanoparticles takes aim at extrahepatic tissues.

Arc Institute is an independent nonprofit research organization headquartered in Palo Alto, California.

Patients with head and neck squamous cell carcinoma (HNSCC) have limited sensitivity to immunotherapies. The authors report the development of TG4050, a modified vaccinia Ankara (MVA) virus-based...

Recent AI developments and what they mean for us Quick primer on general AI models* State-of-the-art in AI agent capabilities AI agents in biology (examples) Discussion - what does this mean for our r...

ALT: Monty Python: I've Had Worse

This Special Communication aims to identify and summarize the most recently published evidence evaluating the effectiveness and safety of US-licensed COVID-19 vaccines and report on the epidemiology o...

The attack by an aggressive “collective” of OpenAI agents shows the danger of artificial intelligence systems that organize themselves.

Hundreds of millions of people have long-term conditions as a result of an infection. Researchers are working out how to help them.

Following on from its success in eradicating malignant B cells in cancer, chimeric antigen receptor (CAR) T cell therapy has been extended to treat autoimmune diseases. This Review discusses the precl...

Inflammation induces interchromosomal DNA interactions that bring parent genes into close proximity, facilitating the formation of chimeric mRNAs that encode physiologically relevant, functional prote...

Nature Metabolism, Published online: 21 August 2026; doi:10.1038/s42255-026-01599-5A multi-organ proteomics resource of diet-induced obesity and its regression in male mice, spanning 15 organs and 4 timepoints, highlights systemic changes as well as impairments in adipose tissue function even under weight loss conditions.

Nature Metabolism, Published online: 21 August 2026; doi:10.1038/s42255-026-01601-0By performing mass spectrometry-based proteomic analysis of 15 organs during progressive weight loss, Boel et al. have created a multi-organ atlas to interrogate the protein-level changes in response to obesity and weight loss in male mice.

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The U.S. Food and Drug Administration today approved Rasonque (daraxonrasib), a RAS inhibitor for the most common form of pancreatic cancer—delivering a new treatment option to patients with advanced ...

An in vivo model that is able to recover human T cells from solid tumours can identify targets to help improve CAR T cell antitumour activity.

Membrane-permeant, environment-sensitive nanosensors enable high-throughput, multiparametric quantification of membrane order and mitochondrial potential, revealing immune-cell-specific remodelling an...