iiinova — where your digital self keeps evolving

Markus Elsner @markuselsner.bsky.social · 15/09/2026

Come on @wellcometrust.bsky.social, why do you need to know this for a scientific grant application:

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Markus Elsner @markuselsner.bsky.social · 03/03/2026

Impressive list of titles to choose from 😂

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Markus Elsner @markuselsner.bsky.social · 16/02/2026

Ich bin ja nicht immer ein Freund der katholischen Kirche, aber hier zeigen sie Haltung! 👏

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Markus Elsner @markuselsner.bsky.social · 08/11/2025

We went to see the fantastic exhibition on Marcus Aurelius in Trier today. Really worth a visit (ends in two weeks, though)

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Markus Elsner @markuselsner.bsky.social · 23/06/2025

at least ChatGPT is honest today (not only the doi was fictitious):

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Markus Elsner @markuselsner.bsky.social · 20/03/2025

First time outdoor office this year 😁

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Markus Elsner @markuselsner.bsky.social · 26/02/2025

Want to know what we do at our startup Deep Piction? Check out our paper with Denali Therapeutics. Using our proprietary clearing & imaging technologies, we mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in whole mouse bodies and monkey brains. go.nature.com/3Xifva2

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Markus Elsner @markuselsner.bsky.social · 16/02/2025

Auch Geisenheim stemmt sich gegen Menschenfeindlichkeit

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Markus Elsner @markuselsner.bsky.social · 31/01/2025

Demo gegen Rechts in Wiesbaden m

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Markus Elsner @markuselsner.bsky.social · 22/12/2024

Found this old postcard today. Seems very appropriate for 2025

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Markus Elsner @markuselsner.bsky.social · 22/11/2024

Also contributing to #FluorescenceFriday (also follow our lab account @erturklab.bsky.social for more stuff like this)

The nervous system of a mouse imaged with tissue clearing and light sheet microscopy

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Markus Elsner @markuselsner.bsky.social · 20/01/2024

Frankfurt gegen Rechts! Römer komplett überfüllt!

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Markus Elsner @markuselsner.bsky.social · 01/10/2023

Spent the weekend in Nürnberg with @christianegshm.bsky.social Great place to visit!

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Markus Elsner @markuselsner.bsky.social · 25/09/2023

Das finde ich ziemlich schockierend

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Markus Elsner @markuselsner.bsky.social · 11/08/2023

Most of the team and of the collaborators have not made the jump from the X site, but a big shout-out to all of them

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Markus Elsner @markuselsner.bsky.social · 11/08/2023

10/n Speculation: Imagine sensors detecting brain health through your skull. Our findings offer hope for early diagnosis & easy follow-up interventions for brain diseases impacting millions globally. The skull's accessibility might even facilitate delivering treatments to the brain.

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Markus Elsner @markuselsner.bsky.social · 11/08/2023

7/n Results 4) Clinical application: TSPO-positron-emission-tomography in the human skull mirrored the underlying brain inflammation in diverse diseases. In stroke patients, inflammation decreased over time, whereas for AD patients, it increased.

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Markus Elsner @markuselsner.bsky.social · 11/08/2023

6/n Results 3) Human imaging data: Embracing our innovative clearing technologies, we made intact human brain-meninges-skull pieces transparent. Surprisingly, we found that SMCs in humans extend beyond the dura, opening up to the sub-dural space!

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Markus Elsner @markuselsner.bsky.social · 11/08/2023

5/n Results 2) Human molecular data: We used proteomics and found a distinct skull proteome compared to vertebra and pelvis. Surprisingly, we identified many unique synaptic proteins in the skull! This might suggest bi-directional communication between the skull and brain.

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Markus Elsner @markuselsner.bsky.social · 11/08/2023

4/n Results 1) Mouse molecular data : We used scRNAseq and proteomics and found that bone marrow cells are heterogeneous throughout the body, and the skull has a unique molecular makeup.

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Markus Elsner @markuselsner.bsky.social · 11/08/2023

3/n Motivation: Our lab and others have recently shown that there are connections between the skull and the meningeal surface of the brain (SMCs) with immune cell trafficking. Thus, the skull might be involved in regulating neuroinflammation.

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Markus Elsner @markuselsner.bsky.social · 11/08/2023

2/n Background: Neuroinflammation, the brain's immune system reaction common in disorders like stroke and dementia, can be like a fire damaging a house. Controlling it is tough as the brain isn't easily accessible.

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Markus Elsner @markuselsner.bsky.social · 04/08/2023

Love this! (stole this from @GlobalEcoGuy on the other place)

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Markus Elsner @markuselsner.bsky.social · 01/08/2023

5/n (Application) Directing Nanoparticle Voyage: By changing bound components, we control the bio-distribution of DNA origami. We demonstrated DNA origami particles are indeed directable in vivo to specific organs and tissues, and targeting moiety can control their distribution.

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Markus Elsner @markuselsner.bsky.social · 01/08/2023

2/n (Summary) Our research outlines how to achieve cell-level precision of nano-carriers in whole mouse bodies by focusing on the safety, biodistribution, and targeting of engineered DNA nanotechnology.

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Markus Elsner @markuselsner.bsky.social · 31/07/2023

Honestly, I don't know what to say:

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Markus Elsner @markuselsner.bsky.social · 25/07/2023

Not quite sure what my first real post here should be but the latest paper from our lab seems fitting: www.nature.com/articles/s41587-023-…

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