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ACR Journals @acr-journals.bsky.social · 2m

New study on chronic recurrent multifocal osteomyelitis translates findings from mouse models to patients Results identify chronic neutrophil activation and upregulation of inflammatory & chemotaxis pathways as prominent features. Many of these features normalized with anti-TNF biologics

Neutrophil-Driven Inflammation in Pediatric Chronic Recurrent Multifocal Osteomyelitis. Graphical abstract made using BioRender

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ACR Journals @acr-journals.bsky.social · 15h

Cross-sectional study using the National Inpatient Sample 2018-2020 showed rheumatoid arthritis was associated with higher odds of discharge health resources need after orthopedic intermediate risk surgery but not composite adverse clinical events or inpatient mortality AC&R doi.org/10.1002/acr....

doi.org

Rheumatoid arthritis, frailty, and outcomes of surgical hospitalizations: A national population‐based analysis

OBJECTIVE Hospitalization, particularly for surgery, represents a period of heightened stress. We evaluated how frailty attenuates the association of rheumatoid arthritis (RA) with negative health o...

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ACR Journals @acr-journals.bsky.social · 19h

Plasma proteomics study reveals distinct protein signatures associated with structural damage in ankylosing spondylitis. A 5-protein panel may help stratify patients by structural damage Arthritis & Rheumatology doi.org/10.1002/art....

Interplay between systemic inflammation and local platelet–extracellular matrix remodeling in pathological ossification. The model integrates local joint inflammation with systemic activation marked by SAA2, which together establish a microenvironment conducive to ossification. Within this environment, growth factor release and progenitor-cell recruitment are enhanced, and these upstream events converge on increased cell–matrix adhesion and ITGA2B-related intracellular signaling. Systemic inflammatory and platelet–ECM pathways thus make partially overlapping contributions to aberrant bone formation.

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ACR Journals @acr-journals.bsky.social · 05/10/2026

Comparing TNF inhibitors and tocilizumab in a combined cohort (n=151) showed similar overall effectiveness Age at symptom onset was assoc with differential biologic response, with younger-onset disease favoring TNFi response, & older-onset disease favoring TCZ response AC&R doi.org/10.1002/acr....

Comparative Effectiveness of Tocilizumab and Tumor Necrosis Factor Inhibitors in Takayasu Arteritis: Age-Related Differences in Treatment Response. Graphical abstract created using BioRender

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ACR Journals @acr-journals.bsky.social · 04/10/2026

A 32-year-old man presented with 3 months of low back pain. Pelvic radiograph showed millimeter-sized opacities corresponding to bone islands in the sacrum, both acetabula, pubis, & ischium, as well as both femoral heads & necks (top left). A coronal T2-weighted fat-suppressed MRI demonstrated ...

Pelvic radiograph showed millimeter-sized opacities corresponding to bone islands in the sacrum, both acetabula, pubis, & ischium, as well as both femoral heads & necks (top left). T1 fat-suppressed sequence hip MRI images similarly revealed numerous millimeter-sized nodular hypointensities consistent with bone islands (top right). Coronal T2-weighted fat-suppressed MRI demonstrated corresponding hypointense bone islands without surrounding bone marrow edema or perilesional reaction (bottom)

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ACR Journals @acr-journals.bsky.social · 04/10/2026

A 53-year-old woman presented with fever & right neck pain. She had a history of breast carcinoma and had undergone chemotherapy with sacituzumab govitecan, which required pegfilgrastim. Seven days after the last pegfilgrastim dose, she developed generalized fatigue, fever, and right-sided neck pain

Contrast-enhanced CT did not reveal the origin of the fever on day 10 (A). Follow-up CE-CT on day 14 showed arterial wall thickening, especially in the right common carotid artery (B). Carotid ultrasonography showed thickening of the outer lines around the bifurcation of the right common carotid artery into the external and internal carotid arteries, strongly suggestive of arteritis (C).

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ACR Journals @acr-journals.bsky.social · 03/10/2026

What does the gut have to do with the heart in scleroderma? In our latest episode, Dr. Zsuzsanna McMahan discusses findings from the GENISOS cohort that shed new light on the relationship between GI and cardiac manifestations in systemic sclerosis. LISTEN → sites.libsyn.com/436041/the-g...

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ACR Journals @acr-journals.bsky.social · 03/10/2026

See what's new this week in Arthritis Care & Research: Generative AI use among reproductive-age women with systemic autoimmune and rheumatic diseases doi.org/10.1002/acr.... Safety of concomitant colchicine and statin therapy doi.org/10.1002/acr.... ...

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ACR Journals @acr-journals.bsky.social · 03/10/2026

Your weekly recap of new research in Arthritis & Rheumatology Case report: BCMA-CAR-T therapy in a patient with refractory APS doi.org/10.1002/art.... Research letter: Real-word safety data on avacopan in AAV doi.org/10.1002/art....

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ACR Journals @acr-journals.bsky.social · 02/10/2026

Mouse model explored β-TrCP2 in bone homeostasis & potential as therapeutic target for osteoporosis Results showed β-TrCP2 regulates osteoclast formation by modulating IKKε–IRF3–IFNβ & NF-κB signaling pathway and influences osteoblast activity by β-catenin accumulation A&R doi.org/10.1002/art....

Dual Effects of β-TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity. A graphical abstract

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ACR Journals @acr-journals.bsky.social · 02/10/2026

Retrospective cohort study evaluated muscle- & liver-related outcomes assoc w/ concomitant colchicine–statin therapy Colchicine-statin therapy was linked to more frequent biochemical abnormalities, but only a modest increase in risk compared with statin therapy alone AC&R doi.org/10.1002/acr....

Cumulative Incidence of (A) Creatine Kinase (CK) Elevation >3× The Upper Limit of Normal (ULN) and (B) Alanine Aminotransferase (ALT) Elevation >5× ULN, by Treatment Group

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ACR Journals @acr-journals.bsky.social · 02/10/2026

📰 Breaking news: ACR Convergence 2026 abstracts are now available! We are proud to have accepted nearly 3,000 abstracts this year. Browse the cutting-edge science → acrabstracts.org ACR Convergence will be held November 6-11 in Orlando, Florida. Learn more → rheumatology.org/annual-meeting

ACR Convergence Abstracts Are Now Available!

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ACR Journals @acr-journals.bsky.social · 02/10/2026

New Immunology for the Rheumatologist review in A&R: T cells in SLE and their contribution to disease pathogenesis and organ damage doi.org/10.1002/art.... Aberrant T cell function contributes to tissue damage and increased susceptibility to infection in SLE T cell-targeted therapeutic strategies

Aberrant T cell function contributes to tissue damage and increased susceptibility to infection in SLE. Autoreactive CD4+ T cells differentiate into pathogenic Th1 and Th17 cells, which produce proinflammatory cytokines including IFN-γ and IL-17that directly contribute to tissue inflammation and organ damage. Follicular T helper (Tfh) or peripheral T helper (Tph) cells provide excessive help to B cells through the production of cytokines, including IL-21 and IL-22, and costimulatory signals, promoting autoantibody production. These autoantibodies form immune complexes that deposit in target organs, activate complement, and drive tissue injury.

T cell-targeted therapeutic strategies in SLE. Therapeutic approaches in SLE modulate immune responses through multiple mechanisms that either enhance the suppressive capacity of regulatory T cells, inhibit pathogenic effector T-cell responses, or redirect T cells to eliminate autoreactive B cells. Treg-directed therapies include low-dose IL-2, which preferentially expands and activates Treg cells, and CARTreg cell therapy, which aims to increase Treg cell numbers, stability, antigen specificity, and suppressive function

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ACR Journals @acr-journals.bsky.social · 01/10/2026

October A&R Clinical Connections (2 of 2) Dual-Targeting BCMA–CD19 CAR-T Cell Therapy in SLE Key Points • Dual-targeting CAR-T therapy was associated with deeper depletion of plasma-lineage compartments compared to single-targeting therapy. ...

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ACR Journals @acr-journals.bsky.social · 01/10/2026

October A&R Clinical Connections (1 of 2) Functional Impact of Structural Damage in Psoriatic Arthritis Key Points • Structural damage affects physical function independently of disease activity and demographics in PsA. • Severity of joint damage matters more than its mere presence, ...

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ACR Journals @acr-journals.bsky.social · 01/10/2026

October A&R - In This Issue: •Long-Term Osteoporosis Progression With DMARDs •Baricitinib Response in Lupus Endotypes •Molecular Endotypes in SLE: CV Risk and LN Insights →Journal Club: Ixekizumab + Tirzepatide in PsA with overweight or obesity acrjournals.onlinelibrary.wiley.com/doi/epdf/10....

Arthritis & Rheumatology In This Issue banner - October 2026 issue

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ACR Journals @acr-journals.bsky.social · 01/10/2026

In this month's issue of Arthritis Care & Research, we present a collection of special articles celebrating 50 years of pediatric rheumatology and the advancements in care that have been achieved. Read the October issue: acrjournals.onlinelibrary.wiley.com/toc/21514658...

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ACR Journals @acr-journals.bsky.social · 30/09/2026

Cross-sectional survey of women ages 18-48 with diverse systemic autoimmune and rheumatic diseases assessed their use of and receptivity to current and hypothetical generative AI tools for health information-seeking Arthritis Care & Research doi.org/10.1002/acr....

Generative AI Utilization and Perspectives Among Reproductive-Age Women with Systemic Autoimmune and Rheumatic Diseases. Graphical abstract made using BioRender

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ACR Journals @acr-journals.bsky.social · 30/09/2026

Two articles in ACROR report data from the Canada-Netherlands Understanding Childhood Arthritis Network (UCAN) CAN-DU & CURE study Analyses examine work & activity impairment across JIA subtypes doi.org/10.1002/acr2... and the health burden of caregivers of children with JIA doi.org/10.1002/acr2...

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ACR Journals @acr-journals.bsky.social · 30/09/2026

First case report of BCMA-directed CAR-T therapy for severe, refractory antiphospholipid syndrome. The patient had triple-positive APS with recurrent, life-threatening diffuse alveolar hemorrhage despite rituximab and high-dose GCs. BCMA CAR-T therapy resulted in a rapid clinical response...

B-cell Maturation Antigen (BCMA)-CAR-T Therapy in a Patient with Triple Positive Antiphospholipid Syndrome and Recurrent Alveolar Bleeding. Graphical abstract made using BioRender

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ACR Journals @acr-journals.bsky.social · 29/09/2026

Data collected from 84 rheumatologists and 511 patients in the US with Sjögren's disease in 2018 shed light on the patient journey, clinical, and patient-reported burden of Sjögren's disease ACR Open Rheumatology doi.org/10.1002/acr2... Figure: Patient journey to diagnosis

Patient journey to diagnosis, physician referral patterns, and tests used for diagnosis and monitoring

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ACR Journals @acr-journals.bsky.social · 29/09/2026

Retrospective study assessed efficacy of IL-1i, IL-6i, TNFαi, or JAKi therapy for VEXAS among 52 patients seen through Aug 2024. IL-6i and JAKi therapies demonstrated limited, unsustained efficacy, while IL-1i and TNFαi therapies were not efficacious ACROR doi.org/10.1002/acr2...

Cumulative incidence of therapy discontinuation

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Reposted by ACR Journals

Wiley Clinical and Health @wileyhealth.bsky.social · 29/09/2026

Research published in Arthritis & Rheumatology reveals that an updated COVID-19 shot is beneficial for those with #autoimmune rheumatic disease. The findings are covered by HealthDay: bit.ly/4yKib0x September is Rheumatic Disease Awareness Month (#RDAM) 💜 @acr-journals.bsky.social

healthday.com

Updated COVID-19 Shot Beneficial for Those With Autoimmune Rheumatic Disease

MONDAY, Sept. 14, 2026 (HealthDay News) -- Among patients with autoimmune rheumatic disease, the odds of COVID-19-related hospitalizations are reduced among tho

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ACR Journals @acr-journals.bsky.social · 29/09/2026

Differences in organ involvement and predictors of treatment response in a multiethnic cohort of patients with IgG4-related disease ACR Open Rheumatology doi.org/10.1002/acr2...

IgG4-to-IgG Ratio and Orbital Involvement Predict Clinical Response to B Cell Depletion in IgG4-Related Disease. A graphical abstract

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ACR Journals @acr-journals.bsky.social · 28/09/2026

Whole-blood transcriptomics identified distinct baseline signatures associated with nonresponse to B cell-targeted therapies in Sjögren’s disease. ESSDAI and STAR captured different biology, highlighting cytotoxic–complement and IL-1/IL-18/FcγR pathways @ciurtinlab.bsky.social @jury-lab.bsky.social

Treatment-driven peripheral blood transcriptomic remodelling and baseline predictors of ESSDAI and STAR response to B-cell therapy in Sjögren's disease. Graphical abstract made using BioRender

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ACR Journals @acr-journals.bsky.social · 28/09/2026

Administering the SIRT6 activator, MDL-800, significantly reduced osteoarthritis severity in aged mice MDL-800-induced activation of SIRT6 repressed pathways associated with bone formation, angiogenesis, vascularization, & neuronal guidance, key features of OA pathology A&R doi.org/10.1002/art....

The effect of MDL-800-induced SIRT6 activation on OA severity at 24 months of age. (A) Experimental design. 18-month-old mice were administered MDL-800 (75 mg/kg) or DMSO vehicle control by IP twice a month for the first month and then weekly for 5 months (6 months total), and OA severity was analyzed by histology. (B) Representative images of H&E and toluidine blue-stained midcoronal sections showing the medial and lateral tibial plateaus and femoral condyles from mice administered DMSO vehicle control or MDL-800. (C) Summed (MTP, MFC, LTP, LFC) OARSI scores, ACS scores, toluidine blue scores, and summed (MTP, LTP) osteophyte scores are presented (control group, n=13; MDL-800 group, n=15). (D) Summed (MTP, MFC, LTP, LFC) synovial hyperplasia, cellularity, and fibrosis scores and representative toluidine blue-stained tissue sections

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ACR Journals @acr-journals.bsky.social · 28/09/2026

Cross-sectional study of 451 adults w/ SLE found that 80% used a dietary supplement, and more than half used multiple supplements Almost 1/3 had a potential supplement–medication interaction, highlighting a potential underrecognized patient safety concern in lupus care AC&R doi.org/10.1002/acr....

Individual supplements taken by adults with SLE with prevalence of at least 5%

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ACR Journals @acr-journals.bsky.social · 27/09/2026

Real-world data from 133 avacopan-treated and 458 control ANCA-associated vasculitis patients showed a small excess of ALT elevation with avacopan, with no vanishing bile duct syndrome observed and similar hospitalization and one-year mortality Research letter in A&R doi.org/10.1002/art....

Avacopan in ANCA-associated vasculitis: real-world safety after postmarketing liver injury signals. Graphical abstract made using BioRender

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ACR Journals @acr-journals.bsky.social · 27/09/2026

A 34-year-old woman was diagnosed with neuro-Behçet disease and initiated the TNF inhibitor adalimumab. One year later, she reported new upper-limb paresthesia, and 3 years later, she developed acute diplopia Clinical images in ACR Open Rheumatology doi.org/10.1002/acr2...

Image caption:
A: T2-weighted MRI showed hyperintense lesions in the pons at time of neuro-Behçet disease diagnosis
B and C: After onset of new neurologic symptoms, T2-weighted MRI showed new white matter and subcortical, periventricular (B), and focal spinal cord lesions (C, arrow).

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ACR Journals @acr-journals.bsky.social · 26/09/2026

Editorial in Arthritis Care & Research presents ideas generated through the NOURISH: Autoimmunity Challenge. The NIH NOURISH: Autoimmunity Challenge crowdsourced innovative and patient-centered ideas from the community, including people living with and at risk of autoimmune disease, ...

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ACR Journals @acr-journals.bsky.social · 26/09/2026

Editorial in A&R: From ADVOCATE to ADVOGATE: is this the end of avacopan? doi.org/10.1002/art.... Figure: The history of avacopan

Figure 1: The history of avacopan.
Initially shown to attenuate glomerulonephritis in a mouse model of ANCA-associated vasculitis in 2014, phase II and III trials quickly followed and avacopan was approved for use across the globe in late 2021 and early 2022. Following release of the Walton report in May 2025, as part of a securities fraud litigation against ChemoCentryx, investigations into the ADVOCATE trial by regulatory bodies began in early 2026.

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ACR Journals @acr-journals.bsky.social · 26/09/2026

Published this week in ACR Open Rheumatology: Efficacy of cytokine-directed therapies in VEXAS doi.org/10.1002/acr2... Changes in IgG4-to-IgG ratios and orbital disease as predictors of B cell depletion response In IgG4-RD doi.org/10.1002/acr2...

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ACR Journals @acr-journals.bsky.social · 26/09/2026

New studies out this week in Arthritis Care & Research: Real-world effectiveness and safety of secukinumab in GCA doi.org/10.1002/acr.... CNS manifestations reported in Sjögren's disease doi.org/10.1002/acr.... Dietary supplement use & potential med interactions in SLE doi.org/10.1002/acr....

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ACR Journals @acr-journals.bsky.social · 26/09/2026

Recap of this week's research in Arthritis & Rheumatology: Aryl Hydrocarbon Receptor regulates uric acid homeostasis doi.org/10.1002/art.... Real-world treatment approaches to macrophage activation syndrome doi.org/10.1002/art....

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ACR Journals @acr-journals.bsky.social · 25/09/2026

An international survey (287 physicians from 64 countries) explored treatment strategies for MAS across different rheumatologic contexts •GCs were consistently identified as 1st-line therapy across all MAS subtypes continues...

Treatment approaches to macrophage activation syndrome in real life and priorities for future research: results from the international METAPHOR project. A graphical abstract

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ACR Journals @acr-journals.bsky.social · 25/09/2026

Mouse model demonstrated aryl hydrocarbon receptor is a regulator of uric acid homeostasis. An additional study conducted in 4 patients affected by glycogen storage disease Arthritis & Rheumatology doi.org/10.1002/art....

$AHR regulates fractional excretion of uric acid. (A): FEUa in control (red) and VAF347-treated (blue) male mice (n=6/group). (B): FEUa in control (red) and VAF347-treated (blue) female mice (n=6/group). (C): FEUa in male Ahr+/+ (red) and Ahr-/- (green) mice (n=6/group). (D): FEUa in female Ahr+/+ (red) and Ahr-/- (green) mice (n=5/group). (E): Urinary sediment due to the presence of crystals in the urine of Ahr-/- mice. (F-G): Polarized light microscopy images of crystals specifically detected in Ahr-/- urine samples. (H,I): Bladder stone collected from a male Ahr-/- mouse. No stones were observed in Ahr+/+mice. (J): Fourier-Transform Infrared (FTIR) spectrum of a bladder stone from an Ahr-/-mouse revealing the presence of ammonium urate.$

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ACR Journals @acr-journals.bsky.social · 25/09/2026

A scoping review synthesized evidence on individuals with Sjögren's disease who experience central nervous system (CNS) manifestations. Results revealed numerous CNS manifestations occur at elevated frequencies in Sjögren's disease Arthritis Care & Research doi.org/10.1002/acr....

A Scoping Review and Meta-Analysis of Proportions of Central Nervous System Manifestations Reported in Patients with Sjögren's Disease. A graphical abstract

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ACR Journals @acr-journals.bsky.social · 24/09/2026

10-year follow-up data from the CRESPA trial of golimumab in early peripheral spondyloarthritis showed 30.6% achieved longstanding drug-free remission. Remarkably, almost half of non-psoriatic peripheral SpA patients remained drug-free Arthritis & Rheumatology doi.org/10.1002/art....

Flowchart of the possible trajectories and number of patients in the different phases of the CRESPA study. W0-W24: start of CRESA study. W24-W48: stop golimumab when sustained clinical remission is achieved

The number of patients who achieved clinical remission (and stopped golimumab) during the CRESPA trial (week 24 to week 48), during the CRESPA extension study and at 10 year follow-up timepoint

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ACR Journals @acr-journals.bsky.social · 24/09/2026

Multicenter retrospective study of patients w/ giant cell arteritis who received secukinumab at 14 Italian centers (N=36) showed secukinumab was assoc with high remission rates (>80%) & increasing GC-free remission over follow-up (40% at 12 months) Arthritis Care & Research doi.org/10.1002/acr....

Remission rate following secukinumab treatment

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ACR Journals @acr-journals.bsky.social · 24/09/2026

In a large Swiss cohort of patients with axial spondyloarthritis (N=376, mean [SD] follow-up 11.5 [8.6] years), early diagnosis of axSpA within 2 years after back pain onset was associated with significantly lower long-term spinal structural damage Arthritis & Rheumatology doi.org/10.1002/art....

Differences in long-term radiographic damage and time to median progression between early (yellow line) and established axSpA (blue line) in the fourparameter logistic (FPL) model (model 2)

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ACR Journals @acr-journals.bsky.social · 23/09/2026

Single-cell RNA sequencing study of PBMCs from patients with myositis ± myocarditis showed a potential role of B cell/antibody-mediated responses and NK cell activation in patients with IIM who develop myocarditis ACR Open Rheumatology doi.org/10.1002/acr2...

Patients with myocarditis and myositis (M+M) have distinct immune cell compositions and gene expression signatures. (A) Experimental design of peripheral blood mononuclear cell (PBMC) pooling for single-cell RNA sequencing (scRNAseq). (B) Uniform Manifold Approximation and Projection (UMAP) of the cell type clusters. (C) Top 10 significantly enriched gene ontology biologic process pathways per cell type in patients with M+M versus (v) patients with myositis without myocarditis (M). Comparisons to healthy controls (HCs) are also shown. (D) Natural killer (NK) and T cell, (E) monocyte, and (F) B cell subcluster UMAPs by disease group (left) and the proportion of these subpopulations in each disease group (right).

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ACR Journals @acr-journals.bsky.social · 23/09/2026

Transcriptomic profiling in skeletal muscle identified associations w/ knee OA in 523 participants of the SOMMA study Gene associations include BDNF & IRF2. Enriched pathways include branched chain amino acid catabolism, DNA replication & repair, & fatty acid metabolism A&R doi.org/10.1002/art....

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA). Graphical abstract is AI-generated

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ACR Journals @acr-journals.bsky.social · 23/09/2026

Are some immunosuppressants safer in SLE? In a target trial emulation of 6168 patients, differences in serious infection risk were initially observed across treatments but attenuated after accounting for glucocorticoid exposure Arthritis & Rheumatology doi.org/10.1002/art.... @aliduarte.bsky.social

Comparative Safety of Common Immunosuppressant Therapies in Systemic Lupus Erythematosus: A Target Trial Emulation Study. A graphical abstract

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ACR Journals @acr-journals.bsky.social · 22/09/2026

Enrollment in the RISE registry was associated with significant improvements in 3 out of 4 rheumatology-specific quality measures for practices with lower baseline performance. Findings suggest registry participation may accelerate uptake of best practices and narrow performance gaps across sites

Segmented regression analysis with mean practice-level performance among high- (blue) and low- performing practices (red). Performance on 6 quality measures was examined 12 months before and 18 months after registry enrollment. The dotted line represents the start of the intervention, Month 0, when practices first joined the RISE registry.

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ACR Journals @acr-journals.bsky.social · 22/09/2026

Retrospective study of patients with early diffuse cutaneous systemic sclerosis or at risk of dcSSc (n=92; median follow-up 5.5 years) reviewed phenotypes of patients with RNAP3+, Scl70+, and triple-negative (RNAP3, Scl70, ACA neg) autoantibody profiles ACR Open Rheumatology doi.org/10.1002/acr2...

Scleroderma-Specific Autoantibodies and Disease Trajectories in Early Systemic Sclerosis: Insights From a Single-Center Prospective Registry. Graphical abstract made using BioRender

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ACR Journals @acr-journals.bsky.social · 22/09/2026

Focus groups of children w/ JIA & their parents investigated perspectives on AI use in JIA care Patients & parents were enthusiastic about AI in treatment decision-making when used as clinical decision support, but expressed concern about physician over-reliance on AI diminishing clinical judgment

doi.org

Patient Perspectives and Expectations on the Use of Artificial Intelligence to Guide Treatment Decision‐Making in Juvenile Idiopathic Arthritis: A Qualitative Study

Objective Artificial intelligence (AI) is rapidly transforming clinical decision-making. However, patient perspectives on these technologies remain understudied in pediatric care. We investigated pa.....

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ACR Journals @acr-journals.bsky.social · 21/09/2026

Is CPPD disease more heterogeneous than we thought? A data-driven analysis identified 4 distinct clinical phenotypes, including 2 patterns not captured by current EULAR phenotypes, one with prominent polyarticular and PMR-like features Arthritis & Rheumatology doi.org/10.1002/art....

Exploring the potential of cluster analysis in identifying disease phenotypes in CPPD: Moving from intuition to insight. Graphical abstract created using BioRender

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ACR Journals @acr-journals.bsky.social · 21/09/2026

Latent class analysis of this survey study data from patients reporting myositis pain identified 4 distinct pain phenotypes. The phenotypes ranged from a more localized, flare-associated disease-related nociceptive pattern to a widespread fibromyalgia-like nociplastic pattern, ...

Distribution of pain across body regions in all four latent classes.
Footnote: manually adapted from the body pain diagram by Margolis et al. Color intensity represents the proportion of patients reporting pain in each anatomical region, with darker shading indicating higher frequency

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ACR Journals @acr-journals.bsky.social · 21/09/2026

Post hoc analysis of a phase 2b trial of zasocitinib (TYK2 inhibitor) for psoriatic arthritis showed reduction of plasma biomarkers related to TYK2 signaling response, inflammation, skin & joint pathogenesis, and cartilage/bone turnover ACR Open Rheumatology doi.org/10.1002/acr2...

Impact of Selective Tyrosine Kinase 2 Inhibition With Zasocitinib (TAK-279) on Molecular Pathways and Correlated Clinical Response in Patients With Active Psoriatic Arthritis. A graphical abstract

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ACR Journals @acr-journals.bsky.social · 20/09/2026

Case report describes a 49y/o woman who experienced improvement in rheumatoid arthritis pain, swelling, & function temporally associated with intravenous NAD+ infusion Img: Representative musculoskeletal ultrasonography at baseline & follow-up after intravenous NAD+ therapy doi.org/10.1002/acr2...

Representative musculoskeletal ultrasonography at baseline and follow-up after intravenous NAD+ therapy. Baseline images demonstrate synovial hypertrophy involving the (A) right second metacarpophalangeal joint, (B) left first metacarpophalangeal joint, and (C) right fourth metacarpophalangeal joint, with Doppler hyperemia visible in panels A and C, consistent with active synovitis. (D–F) Corresponding follow-up images show no visible synovial hypertrophy or Doppler hyperemia in the displayed views. The baseline and follow-up examinations were obtained at different time points and with different ultrasonographic settings; therefore, the images provide a qualitative rather than standardized quantitative comparison

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