Abstract. Evolutionary trajectories are determined by selection and the underlying genetic architecture of additive genetic variances and covariances for t

I have written before about how two conceptual frameworks have shaped our thinking about cell fate, Waddington's epigenetic landscape and Davidson's gene...

Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

Squamate pregnancy is an important topic in reproductive and evolutionary biology, as it provides insight to amniote live-bearing that is not mammalian. Gene regulation in squamates is poorly charact...

Polymorphic gene duplications absent from the reference genome can generate spurious trans-eQTLs. Specifically, variants tagging the polymorphic duplicate may masquerade as trans-eQTLs regulating the ...

Nature Communications - How non-coding mutations in DNA contribute to phenotypes is a largely unresolved question. Here the authors integrate personal genomics and machine learning to identify...

Alternate RNA decoding, an understudied process, leads to peptide sequence modifications that can have substantial functional effects on protein stability, tissue-specific proteomes and disease.

The Selfish Gene continues to challenge readers half a century later

Abstract. Local adaptation is often portrayed as uniform fitness disadvantages of immigrants relative to locals. Yet dispersal costs vary with origin, sex

Abstract. Twenty-five years ago, the book The Ecology of Adaptive Radiation by Dolph Schluter presented a testable framework that integrated ecology, genet

Abstract. A current goal of speciation research is identifying loci underlying reproductive barriers between species. Locating barrier loci in population g

Introductions of species outside their native range, such as pink salmon (Oncorhynchus gorbuscha) in the Laurentian Great Lakes, can serve as unplanned experiments that provide new insights into ecol....

Nature Reviews Genetics - Genome-wide association studies of increasing scale have revealed the prevalence of pleiotropic genetic variants that affect multiple traits. In this Review, the authors...

Author summary Many plants avoid self-fertilization through a system of self-incompatibility, which allows them to recognize and reject their own pollen. In plants like those in the Arabidopsis family...

The genomics program opened up the ‘black box’ of wild fish research. Former and current staff say it’s been gutted.

Top predators drive changes in ecosystem structure. For the last ~370 million years, large-sized vertebrates have dominated the apex of the marine food chain, while invertebrates have served as smalle...

Background Genome evolvability involves activation of transposable elements (TEs) that result in novel genomic rearrangements, including translocations, deletions, duplications, as well as larger stru...