Recent work has shown that commensal gut bacteria can evolve rapidly within hosts on short timescales of days to months, fueled by the enormous mutational input generated daily in the microbiome. Yet ...

The extent to which human adaptations have persisted throughout history despite strong eroding demographic events such as admixture, genetic drift,...

Predicting the effect of a genetic mutation on fitness is a major challenge in evolutionary biology. This study uses fitness effects of a large collection of adaptive yeast mutants in multiple lab env...

Complex prophage integration dynamics, including low-level induction, cross-family host range and transposase-mediated mobilization, challenge existing paradigms and deepen our understanding of phage–...

In this study, we asked whether normalization by host reads alone was sufficient to estimate absolute bacterial biomass directly from stool metagenomic data, without the need for synthetic spike-ins, ...

Not all genes respond in the same way to regulation by the same molecule—a property that might enable cells to produce complex genetic responses.

The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

Bacterial colonies growing on solid surfaces can exhibit robust expansion kinetics, with constant radial growth and saturating vertical expansion. Here, the authors use modeling and experiments to sho...

This paper presents a multi-hub conference on microbial ecology and evolution, analyzing participant and organizer feedback to provide a template and recom

Bacteria have a simple yet potent mechanism that controls their sensitivity to environmental stimuli. A new study by researchers at the Univer...

“Paradox of the sub-plankton: Plausible mechanisms and open problems underlying strain-level diversity in microbial communities” by Akshit Goyal* and Griffin Chure*. This work highlights the limitati...

When President Donald Trump named Robert F. Kennedy Jr. as his choice to lead the US Department of Health and Human Services, one group of health researchers was cautiously optimistic that their cause...

Posted 4:13:15 PM. The OpportunityWe are looking for a talented Computational Biologist to spearhead the analysis of…See this and similar jobs on LinkedIn.

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The consumption of sugar has become central to the Western diet. Cost and health concerns associated with sucrose spurred the development and consumpt…

B cell germinal centres achieve a balance between clonal expansion and sequence diversification by suppressing somatic hypermutation during proliferative clonal bursts.

Nature Reviews Microbiology, Published online: 11 March 2025; doi:10.1038/s41579-025-01157-yIn this Review, Lang and colleagues present an overview of the current knowledge landscape regarding mobile genetic elements in bacteria, with a focus on their…

Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are...

Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are...

Tn-seq and live imaging of Pseudomonas aeruginosa during airway epithelial organoid infections reveal metabolic adaptations and trade-offs between growth and antibiotic tolerance in biofilm lifestyle,...

Evolvability modifier mutations alter the rates and benefits of future mutations, but it is difficult to predict when they will be favoured by natural selection. A mathematical framework shows that co...

Bacteria acquire new genes by horizontal gene transfer (HGT). Acquisition is typically mediated by m

Microbial communities perform many important functions, such as carbon sequestration, decomposition, pathogen resistance, etc., but quantitatively predicting functions of new communities remains a maj...

Direct measures of inner gastrointestinal signals via ingestible capsules highlight the role of stomach pH in shaping human feelings of disgust, fear and happiness.

Lolamicin, a novel antibiotic developed from a pyridinepyrazole precursor, exhibits potent activity against a broad range of Gram-negative multidrug-resistant clinical isolates, and good efficacy...

Store-bought milk could provide a work-around, University of Washington and Fred Hutchinson researchers suggested, similar to wastewater surveillance.

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An Owner's Guide to the Human Genome

Despite an increasingly detailed picture of the molecular mechanisms of bacteriophage (phage)–bacterial interactions, we lack an understanding of how these interactions evolve and impact disease withi...