iiinova — where your digital self keeps evolving

Manuel Kaulich @manuelkaulich.bsky.social · 29/09/2026

Organized by Claudia Scholl (Heidelberg) and me.

Manuel Kaulich @manuelkaulich.bsky.social · 29/09/2026

Please join us! 78th GBM Mosbach Colloquium: Precision Cancer Medicine: From Molecular Mechanisms to Therapeutic Innovation Mosbach, Germany: Mar 17–20, 2027  Top speakers, selected talks, posters  Abstracts & reg: Jan 31, 2026 mosbacher-kolloquium.org/78-mosbacher...

mosbacher-kolloquium.org

78th Mosbacher Kolloquium - Mosbacher_Kolloquium.html

Mosbacher Kolloquium der Gesellschaft für Biochemie und Molekularbiologie e.V.

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Manuel Kaulich @manuelkaulich.bsky.social · 05/05/2026

#PERTomics, the systematic functional perturbation of genes and quantification of subcellular, cellular, and organismal responses. To functionally annotate uncharacterized genes, build genetic interaction maps, identify drug dependencies and synergies, and understand polygenetic biology.

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Manuel Kaulich @manuelkaulich.bsky.social · 03/05/2026

DNA guides instead of RNA?! A CRISPR-Cas12a system flips the script, using DNA guides to target RNA. 🔬 Enables direct RNA detection + knockdown 🧬 Reveals a distinct activation mechanism ⚙️ Expands the toolbox for programmable RNA control Big step for CRISPR versatility. www.nature.com/articles/s41...

nature.com

DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage - Nature Biotechnology

Synthetic DNA guides (crDNA) reprogram Cas12a nucleases for RNA targeting.

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Kurianlab @kurianlab.bsky.social · 31/03/2026

Excited host @hohmannulrich.bsky.social from @imbmainz.bsky.social, along with @manuelkaulich.bsky.social Date: 07.04.2026 Time: 15:00 Venue: Haus 22 Seminar Room 1. (S22-1) Title: ‘Mechanistic insights into nuclear mRNA export and degradation’ @goetheuni.bsky.social @cpi-exstra.bsky.social

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Manuel Kaulich @manuelkaulich.bsky.social · 23/03/2026

A fantastic line up of speakers. Hope to see many of you in wonderful Mainhatten (Frankfurt).

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Reposted by Manuel Kaulich

Stegle Lab @steglelab.bsky.social · 12/03/2026

How do immune disease-relevant variants rewire gene regulation in CD4+ T cells? In a collaboration led by Daniel Schraivogel and Lars Steinmetz at @embl.org, we combined two large-scale CRISPRi screens (4.1M cells) to map the downstream cascades of thousands of SNPs.

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Open Targets @opentargets.org · 12/03/2026

Out now on bioRxiv! 🧬🖥️ Dewi Moonen, @anniquec.bsky.social and a team led by Lars Steinmetz and Daniel Schraivogel at EMBL have mapped the downstream regulatory networks of thousands of immune disease-relevant variants in CD4+ T cells www.biorxiv.org/content/10.6...

biorxiv.org

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danielschraivogel.bsky.social @danielschraivogel.bsky.social · 12/03/2026

Very proud to see this work out on bioRxiv. Using genome-scale TAP/Perturb-seq we mapped the function of immune-disease variants to target genes and regulatory cascades. Have a look at the 🧵from @anniquec.bsky.social for more info!

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Manuel Kaulich @manuelkaulich.bsky.social · 12/03/2026

So great to this preprint out. It was/is such a pleasure to work with this fantastic team. Congratulations to all of you!

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IorioLab @ioriolab.bsky.social · 24/02/2026

Insights from the 2nd EuroDepMap Symposium are now out in FEBS Letters. Last November at Human Technopole researchers in cancer functional genomics and computational biology discussed challenges and future directions in mapping cancer vulnerabilities and building predictive frameworks. Link ⬇️

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Manuel Kaulich @manuelkaulich.bsky.social · 22/12/2025

You know your crowed…… thanks for sharing - will take a deep dive.

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Human Technopole @humantechnopole.bsky.social · 21/11/2025

💫 Thank you to all participants and speakers who joined us at the 2nd @eurocancerdepmap.bsky.social Symposium! Together, we’re advancing #cancer functional genomics across Europe. youtu.be/Qt_ozbzM5js

youtu.be

2nd European Cancer Dependency Map Symposium - 20 Nov 2025

YouTube video by Human Technopole

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

The Synthetic Lethality and Innovations in CRISPR Screening session begins with @manuelkaulich.bsky.social telling us about exciting CRISPR libraries they have developed and how nuclear mRNA processing can mask the CRISPRko phenotypes @eurocancerdepmap.bsky.social

Start of the second session of the 2nd EuroCancerDepMap symposium with a talk from Manuel Kaulich

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Constantin Ahlmann-Eltze @const-ae.bsky.social · 04/08/2025

Our paper benchmarking foundation models for perturbation effect prediction is finally published 🎉🥳🎉 www.nature.com/articles/s41... We show that none of the available* models outperform simple linear baselines. Since the original preprint, we added more methods, metrics, and prettier figures! 🧵

Beeswarm plot of the prediction error across different methods of double perturbations showing that all methods (scGPT, scFoundation, UCE, scBERT, Geneformer, GEARS, and CPA) perform worse than the additive baseline.

Line plot of the true positive rate against the false discovery proportion showing that none of the methods is better at finding non additive interactions than simply predicting no change.

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Manuel Kaulich @manuelkaulich.bsky.social · 22/05/2025

In times when science must defend itself, the decision by the German Research Foundation (DFG) to significantly support German universities through the Excellence Initiative for the next seven years is a signal that stands unparalleled. www.dfg.de/en/news/news...

dfg.de

Announcement of Clusters of Excellence to Receive Funding in the Future, Thursday, 22 May 2025, from approx. 5 pm

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Manuel Kaulich @manuelkaulich.bsky.social · 27/04/2025

Such a wonderful example of what genetic screens can tell us about human patho/physiology. Cudos @mgarnett.bsky.social, Fiona Behan and many more.

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Manuel Kaulich @manuelkaulich.bsky.social · 24/04/2025

Congratulations! & thanks for letting us contribute to this wonderful story.

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Manuel Kaulich @manuelkaulich.bsky.social · 09/03/2025

Congratulations. On top of my reading list.

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Manuel Kaulich @manuelkaulich.bsky.social · 07/03/2025

If a team wished to include combinatorial gene perturbation and bioinformatics in their program, please reach out.

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Reposted by Manuel Kaulich

Mathew Garnett @mgarnett.bsky.social · 25/02/2025

New Gordon Research Conference Alert: Synthetic Lethality Approaches in Oncology. www.grc.org/synthetic-le.... Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.

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Manuel Kaulich @manuelkaulich.bsky.social · 23/02/2025

80% of Germans (84% participation) voted for democracy. #TogetherAgainstPopulism

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Manuel Kaulich @manuelkaulich.bsky.social · 02/02/2025

If you search for unexpected phenotypes (genetic interactions), aren't they expected when observed? 🤔

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Manuel Kaulich @manuelkaulich.bsky.social · 01/02/2025

Which rate do you consider appropriate, 10% or 1% ?

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Manuel Kaulich @manuelkaulich.bsky.social · 30/01/2025

Thinking about grant alternatives to fund basic research? Provocative thought - How about getting a royalty rate per accessed publication (per corresponding author)?

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The Cancer Dependency Map @depmap.org · 29/01/2025

📣Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute) Highly recommended! Register here grc.org/synthetic-le...

grc.org

2025 Synthetic Lethality Approaches in Oncology Conference GRC

The 2025 Gordon Research Conference on Synthetic Lethality Approaches in Oncology will be held in Portland, Maine. Apply today to reserve your spot.

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Manuel Kaulich @manuelkaulich.bsky.social · 18/01/2025

Hi Vanessa, I can contribute to Cancer Biology, Functional genomics, and Bioinformatics. Please add me to the pack.

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Manuel Kaulich @manuelkaulich.bsky.social · 14/01/2025

The German Research Council, aka DFG, is on BlueSky. Welcome @dfgpublic.bsky.social

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Manuel Kaulich @manuelkaulich.bsky.social · 19/12/2024

Are you interested in how genes/proteins interact to regulate cellular and organismal physiology? If so, let's grab a coffee at the upcoming #CSHL Network Biology meeting. meetings.cshl.edu/meetings.asp...

meetings.cshl.edu

Network Biology

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

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Manuel Kaulich @manuelkaulich.bsky.social · 11/12/2024

I messed up my earlier message by using the wrong link/date. So here is the correction!! See you in Hinxton (2–4 April, 2025) coursesandconferences.wellcomeconnectingscience.org/event/crispr...

coursesandconferences.wellcomeconnectingscience.org

CRISPR and Beyond: Perturbations at Scale to Understand Genomes — 20250402

Exploring methods to modulate the genome at scale

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Manuel Kaulich @manuelkaulich.bsky.social · 04/12/2024

Thanks for sharing this @durocher1.bsky.social Any chance you have a link to behind the paywall? Thx.

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Manuel Kaulich @manuelkaulich.bsky.social · 28/11/2024

Wow ! Not only the topic, but look at this line up of speakers. How can one not go?

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Manuel Kaulich @manuelkaulich.bsky.social · 26/11/2024

Congrats Julian. Reason to celebrate. You never forget the „first(s)“. 😏

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Manuel Kaulich @manuelkaulich.bsky.social · 26/11/2024

This will be a fantastic meeting and I surely hope to see plenty of you there. Very much looking forward to share our latest.

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Manuel Kaulich @manuelkaulich.bsky.social · 26/11/2024

Related - what is the correlation among two independent sequencing data sets of a highly uniform library? Is correlation the right metric to use?

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