Our mission is to advance the health and wellness of our diverse communities throughout Massachusetts and across the world by leading and innovating in education, research, health care delivery and pu...

Mutations at sites distant from a protein’s active site can disrupt function through allosteric mechanisms. Here, authors present evidence that allostery is a widespread and underappreciated cause of ...

A systematic study of gene essentiality across 18 genetically diverse natural yeast strains identifies 39 genes that are essential in the laboratory reference strain but not in at least one other gene...

When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled to mitochondria, leading to programmed cell death independently of the loss of RNA Pol II transcription activity...

Sometimes the detrimental effects of a mutation can be rescued by another mutation. For genetic diseases, such suppressor mutations may identify new therap

The 2025 Gordon Research Conference on Synthetic Lethality Approaches in Oncology will be held in Portland, Maine. Apply today to reserve your spot.

We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

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