Patient and public involvement and engagement (PPIE) refers to the different ways those with lived experience, including patients, family, friends and carers, and the public engage with the design, de...

A trajectory-based molecular framework reveals coordinated temporal shifts in metabolic, inflammatory and fibrogenic mechanisms across the human MASLD spectrum.

A trajectory-based molecular framework reveals coordinated temporal shifts in metabolic, inflammatory and fibrogenic mechanisms across the human MASLD spectrum.

Understanding how changes in gene function affect disease risk is central to drug development. Genetic variants are natural perturbations of gene activity and provide an opportunity to systematically ...

As a platform grows in complexity, maintaining stability becomes increasingly difficult. The Open Targets Frontend Team has introduced automated end-to-end testing to ensure that core user journeys an...

The latest IBDverse study identifies the genes expressed in Crohn's disease, revealing a lasting 'molecular scar' in the gut lining.

IBDverse is a single-cell RNA atlas of terminal ileal biopsies comprising 1.1 million cells from 111 patients with Crohn’s disease and 232 healthy participants. Analysis of the data identifies genes, ...

Single-cell mapping of cis-expression quantitative trait loci in inflammatory bowel disease revealed distal, enhancer-enriched variants detected at the cell-type level more frequently co-loc...

The Perturbation Catalogue brings genetic perturbation data into one curated, harmonised, and discoverable platform. Once the data is in, how do you ensure it's useful and structured in a way that ans...

Our Shapley value-based explanations for Locus-to-Gene scores presented a design challenge of providing a diverse range of users with an intuitive ‘explanation’ of the score but also ensuring enough d...

Working with a team at the forefront of large-scale biomedical data integration, I learned a great deal about large-scale data processing, reproducible research, human genetics, and the challenges of ...

Marie Moullet describes Tripso—Transformers for learning Representations of Interpretable gene Programs in Single-cell transcriptOmics—a method for single cell data analyses that goes beyond canonical...

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Open licensing and copyright are important aspects of publishing research, but what do they mean in practice? Creative Commons (CC) licences offer a standardised framework for sharing research outputs...

Open licensing and copyright are important aspects of publishing research, but what do they mean in practice? Creative Commons (CC) licences offer a standardised framework for sharing research outputs...

Here the authors implement a comprehensive timestamping across millions of pieces of biomedical evidence supporting target–disease associations in the Open Targets Platform and analyse trends in evide...

We have released the first iteration of a dedicated MCP server to bring our systematic target discovery capabilities to Large Language Model (LLM)-based workflows.

Here the authors implement a comprehensive timestamping across millions of pieces of biomedical evidence supporting target–disease associations in the Open Targets Platform and analyse trends in evide...

Immunotherapies only provide benefit for a subset of individuals with cancer, highlighting the need for biomarkers of response. Using whole-genome CRISPR-Cas9 screens, Watterson et al. map genetic dep...

Scientists pinpoint two cancer genes that when deleted, improve the vulnerability of tumour cells to immunotherapy.

Open Targets is a public-private initiative to generate evidence on the validity of therapeutic targets based on genome-scale experiments and analysis.