Reposted by The Cancer Dependency Map
(1/3) Excited to share our latest work using
@depmap.org to uncover a new synthetic lethality in two distinct patient populations!
We found that SKI complex inactivation through two independent genomic alterations creates a dependency on PELO
#CancerResearch #SyntheticLethality #Genomics #DepMap
nature.com
SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature
Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...
