iiinova — where your digital self keeps evolving

IorioLab @ioriolab.bsky.social · 16/03/2026

Congratulations to Raffaele Iannuzzi (our former PhD student) on his new role as Bioinformatician at TheraMe! We are delighted to see you begin this exciting new chapter and wish you every success in the journey ahead. With warmest wishes from everyone at the @ioriolab.bsky.social! 🎉

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IorioLab @ioriolab.bsky.social · 24/02/2026

Insights from the 2nd EuroDepMap Symposium are now out in FEBS Letters. Last November at Human Technopole researchers in cancer functional genomics and computational biology discussed challenges and future directions in mapping cancer vulnerabilities and building predictive frameworks. Link ⬇️

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IorioLab @ioriolab.bsky.social · 26/01/2026

𝗧𝘄𝗼 𝗶𝗻𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 analyses, 𝗼𝗻𝗲 𝗰𝗼𝗻𝘃𝗲𝗿𝗴𝗶𝗻𝗴 𝘀𝘁𝗼𝗿𝘆: here is 𝗈𝗎𝗋 𝗇𝖾𝗐 𝗌𝗍𝗎𝖽𝗒, 𝗋𝖾𝗅𝖾𝖺𝗌𝖾𝖽 𝖺𝗅𝗈𝗇𝗀𝗌𝗂𝖽𝖾 𝖺𝗇 𝗂𝗇𝖽𝖾𝗉𝖾𝗇𝖽𝖾𝗇𝗍 𝗐𝗈𝗋𝗄 𝖿𝗋𝗈𝗆 𝗍𝗁𝖾 𝗖𝗶𝗿𝗶𝗲𝗹𝗹𝗼 𝗴𝗿𝗼𝘂𝗽 (𝗦𝗲𝘀𝗶𝗮 𝗲𝘁 𝗮𝗹.), 𝗐𝗁𝖾𝗋𝖾 𝖢𝖱𝖨𝖲𝖯𝖱 𝖽𝖾𝗉𝖾𝗇𝖽𝖾𝗇𝖼𝗒 𝗆𝖺𝗉𝗌 𝖺𝗋𝖾 𝗎𝗌𝖾𝖽 𝗍𝗈 𝗍𝖺𝖼𝗄𝗅𝖾 𝗍𝗁𝖾 𝗌𝖺𝗆𝖾 𝖼𝗁𝖺𝗅𝗅𝖾𝗇𝗀𝖾: 𝗆𝖺𝗄𝗂𝗇𝗀 𝗌𝖾𝗇𝗌𝖾 𝗈𝖿 𝖼𝖺𝗇𝖼𝖾𝗋 𝘷𝘢𝘳𝘪𝘢𝘯𝘵𝘴 𝘰𝘧 𝘶𝘯𝘬𝘯𝘰𝘸𝘯 𝘴𝘪𝘨𝘯𝘪𝘧𝘪𝘤𝘢𝘯𝘤𝘦 using DepMap data. Links 👇

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IorioLab @ioriolab.bsky.social · 09/12/2025

Festive vibes in Iorio Lab today: we spiced up the weekly lab meeting with a Secret Santa. Great company, fun gifts and a brief break from pipettes and plots!

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IorioLab @ioriolab.bsky.social · 24/11/2025

@eurocancerdepmap.bsky.social, hosted by Francesco (alongside Pedro Beltrao from ETH Zurich, and Evangelia Petsalaki and Isidro Cortés-Ciriano from EMBL-EBI) at @humantechnopole.bsky.social, has concluded. Great speakers delivered breakthroughs that advance #cancer genomics across #Europe! 🏛️🧬

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

Last but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

And we finish this session with @epetsalaki.bsky.social showing the potential of using CRISPR data to study context specific signalling and drug responses

Evangelia Petsalaki presenting at the 2nd European Cancer Dependency Map Symposium

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

The last session starts with Lodewyk Wessels from @nkinl.bsky.social sharing the work on perturbation response models!

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

@colmr.bsky.social takes the stage to share the work of his group that aims to understand and predict synthetic lethality between paralogs in cancer

Colm Ryan presenting at the 2nd European Cancer Dependency Map Symposium

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

We are back, starting the afternoon session with a joint talk by Debora Sesia/ @ciriellolab.bsky.social and @aurorasavino.bsky.social / @ioriolab.bsky.social showing their work on the functional assessment of Variants of Unknown Significance through cancer dependency map data analysis

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IorioLab @ioriolab.bsky.social · 20/11/2025

The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social

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IorioLab @ioriolab.bsky.social · 20/11/2025

We start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social

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IorioLab @ioriolab.bsky.social · 20/11/2025

Now @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social

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Dr Lizzie Coker @lizziecoker.bsky.social · 20/11/2025

First session of the @eurocancerdepmap.bsky.social symposium and so much fantastic work presented already! #CancerResearch #TranslationalScience #plasticity

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

To wrap up the second session, Roland Rad from the Institute of Molecular Oncology and Functional Genomics is sharing their work on mapping genetic interactions in cancer evolution and therapy @eurocancerdepmap.bsky.social

Roland Rad gives the final talk of the second session of the 2nd European Cancer Dependency Map Symposium

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

We continue with the talk from @icrlordlab.bsky.social focusing on the complexity of synthetic lethality in cancer and how we can move forward in exploiting it @eurocancerdepmap.bsky.social

Talk by Chris Lord at the 2nd European Cancer Dependency Map Symposium

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

The Synthetic Lethality and Innovations in CRISPR Screening session begins with @manuelkaulich.bsky.social telling us about exciting CRISPR libraries they have developed and how nuclear mRNA processing can mask the CRISPRko phenotypes @eurocancerdepmap.bsky.social

Start of the second session of the 2nd EuroCancerDepMap symposium with a talk from Manuel Kaulich

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IorioLab @ioriolab.bsky.social · 20/11/2025

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IorioLab @ioriolab.bsky.social · 20/11/2025

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IorioLab @ioriolab.bsky.social · 20/11/2025

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IorioLab @ioriolab.bsky.social · 19/11/2025

Delighted to host Traver Hart (MD Anderson Cancer Center), who delivered an engaging seminar on synthetic lethality at #HumanTechnopole. He showed how bridging #CRISPR and predictive modeling can advance design and interpretation of genetic interaction screens and inform new therapeutic strategies.

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IorioLab @ioriolab.bsky.social · 29/10/2025

The Iorio Lab is at the 37th AICC International Meeting in Florence this week. With our Francesco Iorio presenting as an invited speaker, Nevenka Radic with a flash talk and Vanessa Spagnolo with a poster. Excited to share our latest results and connect with colleagues in the field.

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IorioLab @ioriolab.bsky.social · 23/10/2025

Kudos to our Flavio Passante for winning with his team the REMEDi4ALL Hackathon in Barcellona! Researchers from 10 countries tackled real-world challenges in drug repurposing for rare neurodevelopmental disorders, spanning the whole pipeline from early target discovery to market access.

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IorioLab @ioriolab.bsky.social · 22/10/2025

Our very own Raffaele Iannuzzi successfully defended his PhD Thesis last week. Raf has worked on benchmarking CRISPRdata analytical tool and predictive models leveraging bulk & single cell RNA-seq data. We will definitely miss him. We wish him all the best as new adventures await! Congrats Raf! 🎉

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IorioLab @ioriolab.bsky.social · 21/10/2025

!!! Less than 2 weeks left to register !!! Join us in Milan for the 2nd European Cancer Dependency Map Symposium, taking place on 20 November 2025 at Human Technopole Cancer functional genomics; CRISPR-based screening; AIdriven targetDiscovery and drug development humantechnopole.it/en/trainings...

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IorioLab @ioriolab.bsky.social · 21/10/2025

Last week we had the pleasure of hosting @maxbillmann.bsky.social at @humantechnopole.bsky.social for an inspiring seminar on genetic interaction maps an networks. Fantastic to learn how CRISPR screens and integrative analyses can illuminate the logic of genetic dependencies. A big thank you Max 👏

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IorioLab @ioriolab.bsky.social · 10/10/2025

Kudos to Yasin Ilkagan Tepeli for defending his PhD at TU Delft (June 2025)! During his PhD at goncalveslab.tudelft.nl, he visited our lab working on Oncostratifier for oncogene-addicted cohort stratification and therapeutic target prediction.

goncalveslab.tudelft.nl

Computational Molecular Biomedicine

in Computer Science Tecnical University of Lisbon

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IorioLab @ioriolab.bsky.social · 11/09/2025

🚨 We’re hiring! 🚨 looking for a computational postdoc to lead an exciting project at the intersection of AI, CRISPR, multi-omics, and cancer genomics. Join us to design the next generation of genetic interaction screens and uncover new synthetic lethalities www.linkedin.com/jobs/view/42...

linkedin.com

Human Technopole hiring Postdoc in Cancer Synthetic Lethality Prediction and AI-Driven Target Discovery in Milan, Lombardy, Italy | LinkedIn

Posted 2:37:53 PM. APPLICATION CLOSING DATE: October 12, 2025Human Technopole (HT) is an interdisciplinary life…See this and similar jobs on LinkedIn.

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IorioLab @ioriolab.bsky.social · 11/09/2025

Today we bid farewell to our postDoc @aurorasavino.bsky.social, who is moving to an independent position at the University of Torino. Her talent dedication and collaborative spirit have left a lasting mark on our team and projects🎉 Wishing you all the best for this exciting next chapter, Aurora! 🥳🍾

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Francesco Iorio @francescoiorio.bsky.social · 25/07/2025

Just back from the GRC on Synthetic Lethality in Oncology: great science, deep discussion, great venue and flawless organisation. Thanks to @mgarnett.bsky.social, Benjamin Schwartz & @vazquezf.bsky.social for leading a fantastic meeting at the frontier of cancer research #SyntheticLethality #GRC

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Francesco Iorio @francescoiorio.bsky.social · 18/07/2025

happy and honoured to have had a chance to deliver a lecture @bocconi.bsky.social University on AIapplications in life sciences and to share exciting projects we are developing at @humantechnopole.bsky.social- A great opportunity to engage with a community that values innovation and forwardThinking

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Francesco Iorio @francescoiorio.bsky.social · 19/06/2025

Proud to announce that the 2nd European Cancer DepMap Symposium has the patronage of AIRC: the Italian Association for Cancer Research. Honoured by their support as we bring together leading scientists on cancer-dependencies functional-genomics CRISPR 🔗 humantechnopole.it/en/trainings... #EuroDepMap

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IorioLab @ioriolab.bsky.social · 18/06/2025

we are at #EACR2025 with two posters - the second one is presented by Ludovica Proietti and Gianluca vozza and focuses on our ERC funded DEPshock project @humantechnopole.bsky.social

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IorioLab @ioriolab.bsky.social · 18/06/2025

we are at #EACR2025 with two posters, one presented by our Ottavio Croci on our collaborative work around a CRISPR based prioritisation of lncRNA vulnerabilities in multiple myeloma @humantechnopole.bsky.social

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IorioLab @ioriolab.bsky.social · 12/06/2025

Big thanks to @floriangrebien.bsky.social for a fantastic seminar yesterday at @humantechnopole.bsky.social 🔬🧬 a masterclass in dissecting AML vulnerabilities with precision and creativity. We loved the science and the lunch chat too! 👏 #cancerbiology #AML #condensates

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IorioLab @ioriolab.bsky.social · 12/06/2025

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IorioLab @ioriolab.bsky.social · 11/06/2025

🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR

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IorioLab @ioriolab.bsky.social · 12/12/2024

🎄🎁 Secret Santa at IorioLab! 🎁🎄 Today, we swapped gifts, laughs, and maybe a few too many inside jokes during our Secret Santa exchange. From creative surprises to hilariously overwrapped packages, everyone brought the holiday cheer 👍 merry Xmas

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IorioLab @ioriolab.bsky.social · 10/12/2024

Amazing Bavarian-style @humantechnopole.bsky.social CompBiol Centre Xmas Dinner w @bioimagecomputing.com @sottoriva.bsky.social and other labs 🍺🎄👍💻🧬

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IorioLab @ioriolab.bsky.social · 28/11/2024

🎓 Huge congratulations to Irene FernandezRebollo and @alessandrodigilio.bsky.social on graduating and successfully defending their master theses on cancer-specific epigenetic clocks! 🧬🕒 Wishing you both great success in your next adventures @manelesteller.bsky.social @humantechnopole.bsky.social

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IorioLab @ioriolab.bsky.social · 26/11/2024

It has been great to be involved in this collaborative project linking ADD3 to cell morphology and vulnerabilities of glioblastoma, using data from the @depmap.org and computational analyses led by our Raffaele Iannuzzi @humantechnopole.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 23/11/2024

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

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IorioLab @ioriolab.bsky.social · 22/11/2024

Kudos to our Flavio Passante for presenting his work on new computational approaches for #drug_repurposing within the NEUROCOV-eu consortium @humantechnopole.bsky.social at the SEMM PhD-student Retreat 2024 and for winning the best poster prize award 🥳🥳

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