The administration of Bacteroides uniformis in mice can mitigate atherosclerosis via pentadecanoic acid, which directly inhibits HMG-CoA reductase to promote hepatic cholesterol clearance.

Fibroblasts exhibit phenotypic and functional heterogeneity in chronic inflammatory diseases, but how these changes impact immune outcomes remains poorly understood. We identified that a fibroblast po...

A balanced human diet comprises carbohydrates, fats, and proteins, along with vitamins and minerals, which are required to sustain physiological functions. In many Western diets, protein often takes c...

Cell Research - No time to die: cell death predicts IBD relapse

Porat et al. develop cell surface ATAC-See, discovering that mitochondrial DNA is a component of the mammalian cell surface. Cell surface DNA (csDNA) on primary human and murine B cells and monocytes is removed by the secreted nuclease DNASE1L3, and dysregulation of csDNA levels is associated with autoimmunity.

Glutathione (GSH) robustly defends against ferroptosis independently of GPX4. FSP1 utilizes GSH to reduce ubiquinone and subsequently inhibits ferroptosis, which is distinct from the NAD(P)H-FAD axis....

Porat et al. develop cell surface ATAC-See, discovering that mitochondrial DNA is a component of the mammalian cell surface. Cell surface DNA (csDNA) on primary human and murine B cells and monocytes ...

Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...

BACH2 restrains activation of the fetal-haemoglobin-encoding γ-globin genes, while loss of BACH2 enhances NRF2 chromatin occupancy and promotes the formation of activation foci at the γ-globin genes.

Mechanisms by which primary tumor cells acquire metastatic capability through metabolic and signaling adaptations are currently poorly understood. We demonstrate that tumor-intrinsic ceramide metaboli...

BOSTON, MA [Sept. 23, 2026] — Our understanding of how cells interact with each other has been driven for decades by the central concept of receptor-mediated

Join the IFN lambda Satellite Workshop 2026 in Glasgow. Free registration, keynote speakers, and research collaborations.

TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.

TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.

How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-dependent,...

A multimodal analysis of patients with multiple myeloma who developed enterocolitis following BCMA CAR-T cell treatment shows that CAR-T cell-associated enterocolitis is not defined exclusively by pla...

A cancer cell glutamine transporter creates a metabolic barrier to antitumor immunity.

The metabolic state of NK cells affects their innate immune function, and although cell-intrinsic pathways are better known, their cellular environment could provide cues that are less studied. Here t...

Tissue mitochondrial activity controls macrophage abundance by regulating CSF1 availability, thereby enabling efficient waste removal.

Fagniez et al. identify new patients with inherited RORγT deficiency characterized by impaired TCRα rearrangement, depletion of MAIT and iNKT cells, reduce

In aging hosts, platelet serotonin fuels lung-damaging clots, leading to enhanced respiratory distress in the context of COVID-19.

Neutrophil extracellular traps (NETs) feature a branched chromatin architecture whose origin and function remain unknown. We found that NET branching is mediated by RAD51, a protein generating DNA jun...