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Li Wang

@liwangneuro.bsky.social
169 followers 402 following 14 posts

Assistant Professor at at Stanford Biology & Stem Cell Institute. Studying human brain development through genomics and proteomics. Website: www.liwanglab.org

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Reposted by Li Wang
Sean Carroll @seanmcarroll.bsky.social · 16/07/2025
Here is my colleague Adam Riess, Nobel laureate, sharing his thoughts on advocating for science at a recent event at the US Capitol. aas.org/posts/news/2...
aas.org
My Recent Experience Advocating for Science | American Astronomical Society
AAS member and Nobel Prize Laureate Adam Riess describes his experience giving a speech to Congress at a recent event at the Capitol, "A Science Fair of Canceled Grants."
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
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Science Magazine @science.org · 02/05/2025
President Donald Trump today asked Congress to make massive and unprecedented cuts to the 2026 budgets of major federal science agencies. scim.ag/3Yszqnm
scim.ag
Trump’s proposed budget would mean ‘disastrous’ cuts to science
Key research budgets would shrink by one-third to one-half in 2026 spending plan
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Ardem Patapoutian @ardemp.bskyverified.social · 03/05/2025
The president is recommending a 40% cut to next year’s NIH budget. This would be disastrous for our nation’s health and economy. Please contact your representatives, especially if they are Republicans, and tell them why this cannot happen. An easy option: 5calls.org
5calls.org
5 Calls
Spend 5 minutes. Make 5 calls. Make your voice heard.
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NPR @npr.org · 09/04/2025
Effective immediately, the government says it will begin screening immigrant social media for activity that officials think indicates support for antisemitism.
npr.org
U.S. says it is now monitoring immigrants' social media for antisemitism
Effective immediately, the government says it will begin screening immigrant social media for activity that officials think indicates support for antisemitism.
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Li Wang @liwangneuro.bsky.social · 04/04/2025
Orderly specification and precise laminar deployment of mouse cortical projection neuron types through intermediate progenitors. www.cell.com/developmenta...
cell.com
Orderly specification and precise laminar deployment of mouse cortical projection neuron types through intermediate progenitors
Inside-out laminar patterning is a fundamental mechanism in cortical neurogenesis, but sequential specification and precise laminar deployment of projection-defined excitatory neuron types also arises...
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c0nc0rdance @c0nc0rdance.bsky.social · 26/03/2025
This a sign of the dark times in which we live & I'm not bragging about it. My team posted an open position for an industry research scientist and we got 20 times the response rate in the 1st week we normally would & the seniority of the applicants was way higher than the norm. All from academia.
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 17/03/2025
High-throughput single cell -omics using semi-permeable capsules www.biorxiv.org/content/10.1101/202…
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Johanna Joyce @johannajoyce.bsky.social · 20/03/2025
How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪 Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻 🧵 @cp-immunity.bsky.social www.cell.com/immunity/ful...
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Moritz Gerstung @moritzgerstung.bsky.social · 17/03/2025
Spatial transcriptomics holds great promise to understand biological tissue function, but the assignment of transcripts to cells has been a substantial bottleneck. For this reason, Elyas Heidari, a student in my lab and in @steglelab.bsky.social built segger. www.biorxiv.org/content/10.1...
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Kathleen Bachynski @bachynski.bsky.social · 15/03/2025
“Nobody feels like their job is safe. Everyone is on edge,” said Kim Hasenkrug, an NIH scientist emeritus… “Even the top people can’t keep track because they’re hiring and firing so much. Direct supervisors of those who were terminated didn’t even know that it was happening.”
statnews.com
At NIH, ‘everyone is on edge’ as they brace for deep cuts and more centralized control
As the NIH braces for cuts of up to 5,000 of its 20,000 positions, “people are scrambling and freaking out,” a researcher said.
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Nagissa Mahmoudi @nagissa.bsky.social · 16/03/2025
Wow this is a game changer. PhD scholarships and postdoctoral fellowships are now open to non-Canadians.
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The Wall Street Journal @wsj.com · 11/03/2025
The Trump administration has terminated $800 million in grants to Johns Hopkins University, spurring the nation’s top spender on research and development to plan layoffs and cancel health projects
wsj.com
Johns Hopkins Plans Staff Layoffs After $800 Million Grant Cuts
Local and international health research efforts are already winding down as the university braces for even more potential cuts.
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Catherine Dulac @dulaclab.bsky.social · 05/03/2025
After last week publication from the lab on circuits of social isolation/satiety, today we publish a different line of research by @harriskaplan.bsky.social et al., on the development trajectories of hypothalamic POA cell types driving survival and social behavior. www.nature.com/articles/s41...
nature.com
Sensory input, sex and function shape hypothalamic cell type development - Nature
Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with ke...
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Dr. Anusha Seneviratne @anushans.bsky.social · 01/03/2025
🧪 This study highlights why we should not focus so much on genetic factors or drug targets. The #exposome (environmental exposures) has greater impact on disease patterns and premature mortality than genetic factors. www.nature.com/articles/s41... #planetaryhealth #academicsky #medsky #idsky
nature.com
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...
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Esther Klingler @estherkli.bsky.social · 20/02/2025
✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do. www.biorxiv.org/content/10.1...
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BWJones @bwjones.bsky.social · 20/02/2025
It’s @katherinejwu.com with the receipts. The NIH memo undercutting the NIH came directly from Trump officials. www.theatlantic.com/health/archi...
theatlantic.com
The NIH Memo That Undercut Universities Came Directly From Trump Officials
NIH officials said they were given no advance warning and less than an hour to post the memo publicly.
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Nick Burton @nickburton.bsky.social · 18/02/2025
One of the coolest and most novel findings I’ve seen in years. This is why I work in worms. To find things no one even really knew to look for. Like a conserved system that splices transposons out of mRNAs to prevent otherwise lethal insertions in essential genes! - www.biorxiv.org/content/10.1...
biorxiv.org
An RNA Splicing System that Excises Transposons from Animal mRNAs
All genomes harbor mobile genetic parasites called transposable elements (TEs). Here we describe a system, which we term SOS splicing, that protects C. elegans and human genes from DNA transposon-medi...
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Slim Mzoughi @sleemmz.bsky.social · 12/02/2025
🔈We've got the cover of the 2nd NG issue for 2025🙌 Read about the cover: In the comment👇 Also check out our research briefing🚨 (link below): nature.com/articles/s41... nature.com/articles/s41...
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Jeremy Berg @jeremymberg.bsky.social · 12/02/2025
The no cost extension button is back and at least some are being granted. If this applies to you, go for it. PLEASE SHARE
media.tenor.com
a man in a suit and tie says go for it in white letters
ALT: a man in a suit and tie says go for it in white letters
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 05/02/2025
Another crazed change from the Trump Administration: removing the NIH No-cost extension form
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Aurina Arnatkeviciute @aurinaarn.bsky.social · 09/02/2025
Do psychiatric GWASs find drug targets? Excited to see our work linking GWAS and pharmacological treatments in psychiatric disorders now published in JAMA Psychiatry jamanetwork.com/journals/jam... 🧬💊🎯 Big thanks to @bendfulcher.bsky.social @alexfornito.bsky.social Mark Bellgrove 🧵👇
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Joseph Yaroch @jcyaroch.bsky.social · 02/02/2025
Today is Retraction Day, when we observe the anniversary of the retraction (Feb. 2, 2010) of the fraudulent paper that purported to show a link between vaccines and autism. 🧪#medsky
This is the front page of a fraudulent research article that purported to show a link between vaccines and autism. The word "RETRACTED" is written across it in large red letters. 

Wikipedia: On 28th February 1998, a fraudulent research paper by physician Andrew Wakefield and twelve coauthors, titled "Ileal-Lymphoid-Nodular Hyperplasia, Non-Specific Colitis, and Pervasive Developmental Disorder in Children", was published in the British medical journal The Lancet.[1] The paper falsely claimed causative links between the measles, mumps, and rubella (MMR) vaccine and colitis and between colitis and autism. The fraud involved data selection, data manipulation, and two undisclosed conflicts of interest.
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Sarah Best @sarahannbest.bsky.social · 13/01/2025
Now on BioRxiv: we explored patient-derived GBM organoids & spheroids generated from the same resected tissue. Critically, both models maintain tumor cell composition & heterogeneity, with comparable tissue resemblance across data modalities (1/4) www.biorxiv.org/content/10.1...
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Alexandre Baffet @alexbaffet.bsky.social · 09/01/2025
Our new paper is out in BioRxiv. Using human fetal tissue and cortical organoids, we figured out how human bRG cells colonize the developing neocortex to expand the oSVZ stem cell niche. Turns out, it's a more complex process than we had anticipated! www.biorxiv.org/content/10.1...
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Cedric Boeckx @cedricboeckx.bsky.social · 09/01/2025
Excellent work by @liwangneuro.bsky.social Arnold Kriegstein and colleagues, deepening our understanding of the molecular and cellular dynamics of the developing human neocortex. The identification of a tripotential intermediate progenitor subtype is a key finding 🧪🧠🧬 www.nature.com/articles/s41...
nature.com
Molecular and cellular dynamics of the developing human neocortex - Nature
Tripotential intermediate progenitor cells are responsible for the local production of GABAergic neurons, oligodendrocyte precursor cells and astrocytes in the human neocortex.
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Li Wang @liwangneuro.bsky.social · 09/01/2025
Brain cancer leverages the same tools as the developing brain 🧠! In our new study from the Kriegstein and Li labs, published today in @nature.com, we mapped neocortical development to explore brain cancer and neuropsychiatric risks. #stemcells #brainresearch www.nature.com/articles/s41...
nature.com
Molecular and cellular dynamics of the developing human neocortex - Nature
Tripotential intermediate progenitor cells are responsible for the local production of GABAergic neurons, oligodendrocyte precursor cells and astrocytes in the human neocortex.
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Richard Sever @richardsever.bsky.social · 21/12/2024
Many academics point to bioRxiv as “the one thing improving science publishing”. If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
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Silvia De Rubeis @derubeislab.bsky.social · 23/11/2024
We are recruiting a postdoc! Have expertise in RNA biology and want to apply it to neuro and neurodev disorders? Then apply 👇🏼 📌 $73,588 💰 📌 access to postdoc housing 🏠 📌 Support for internationals 🌍 📌 Awesome view 😅 🙏 RT labs.icahn.mssm.edu/derubeislab/...
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Joel Babdor @joelbabdor.bsky.social · 23/11/2024
Wow, there's a lot of us here now. Reintroducing myself: I am Joel 👋🏿. My lab studies how the microbiome shapes the immune system in health & disease, using a mix of bench and computational approaches. I am also passionate about mentoring the next generation of scientists 🥼. #immunology #microbiome
Joel in his office, sitting at his desk.
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Manuel Thery @manuelthery.bsky.social · 23/11/2024
@embl.org is searching for a "highly experienced, inspirational and dynamic leader" to serve as its new director general. Who do we wish to see at this position?
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Anshul Kundaje @anshulkundaje.bsky.social · 22/11/2024
www.anthropic.com/research/sta... This is an excellent attempt (blog & paper) at bringing more statistical rigor to evaluation of ML models (this is specifically focused on LLM evals). I feel like we need to have similar clear standards for many types of predictive models in biology. 1/
anthropic.com
A statistical approach to model evaluations
A research paper from Anthropic on how to apply statistics to improve language model evaluations
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Rachael Ott @rachaelott.bsky.social · 22/11/2024
Happy #FluorescenceFriday! Another favorite from 2024. Neurofilament #cytoskeleton and tau shown in a primary hippocampal neuron 🔬 #microscopy #neuroscience
Neurofilament (fire) and tau (cyan) proteins are shown in a primary hippocampal neuron.
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zara weinberg @weinberz.witchlab.org · 21/11/2024
UCSF hosted its first food pantry event for postdocs today, where a local food bank gives free food to UCSF employees. This picture represents about half the line that had formed 10 minutes before the market had opened. What the fuck are we doing here guys?
A crowd of people wraps around a hallway. About 25-30 people are visible
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Fabian Theis @fabiantheis.bsky.social · 20/11/2024
1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces. biorxiv.org/content/10.1101/2024.11.06.622266v1
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Cedric Boeckx @cedricboeckx.bsky.social · 21/11/2024
The integrated transcriptomic cell atlas of human neural #organoids, Barbara Treutlein's lab, @fabiantheis.bsky.social @graycamplab.bsky.social @sergiuppasca.bsky.social @giorgiaquadrato.bsky.social and colleagues: www.nature.com/articles/s41...
nature.com
An integrated transcriptomic cell atlas of human neural organoids - Nature
A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid counterparts, sho...
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Emilie Wigdor @emiliewigdor.bsky.social · 20/11/2024
📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣 Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
media.tenor.com
a couple of cartoon characters standing next to each other with one wearing a purple earring
Alt: a couple of cartoon characters standing next to each other with one wearing a purple earring
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 18/11/2024
And big-lab-group-think is a stifling influence. Last month I gave a talk at a local big pharma site and the director/host literally asked me “if [insert three big names of field] haven’t already thought of the idea you presented, how could it possibly be true/important?”
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Jacob Schreiber @jmschreiber91.bsky.social · 18/11/2024
My goal is to understand the regulatory role of every nucleotide in the genome, and how this changes across every cell in the human body. If you are interested in doing a Ph.D. with me at UMass Chan Medical (Genomics and Comp Bio Department), see the links below. Deadline is Dec 1st.
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Denis Wirtz @deniswirtz.bsky.social · 17/11/2024
Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download freely here: research.jhu.edu/rdt/funding-...
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Ayanna Kim Thomas @ayannakim.bsky.social · 17/11/2024
More than ever, prospective PhD students are requesting meetings w/ me prior to submitting their application (due Dec 1). I traditionally do not meet because I think it creates inequities. (Not everyone knows to ask. I cannot meet w/ everyone who applies.) How do others handle this?
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Krista Joan Green @krista-joan-art.bsky.social · 16/11/2024
Happy Saturday from Canada! 🇨🇦
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Arjun Raj @arjunraj.bsky.social · 17/11/2024
This worked for me!
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Itai Yanai @itaiyanai.bsky.social · 17/11/2024
We need to have a ‘code of conduct’ for reviewing manuscripts, like (1) if you say that something is not novel then provide the reference. (2) If you propose an experiment, state precisely to which claim it is crucial. (3) If you want to say something nasty then sign your name.
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