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Sarah Best

@sarahannbest.bsky.social
456 followers 534 following 6 posts

Co-lead Brain Cancer Research Lab @WEHI and Brain Cancer Centre in Australia

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Reposted by Sarah Best
WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 22/08/2025
Researchers from WEHI, the Royal Melbourne Hospital & @petermaccc.bsky.social have achieved a brain cancer clinical trial world-first, providing hope to patients with low-grade gliomas. 🔗 www.wehi.edu.au/news/world-f...
The BrainPOP research team (left to right): Professor Kate Drummond, Dr Jim Whittle, Dr Saskia Freytag, Dr Sarah Best
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Sarah Best @sarahannbest.bsky.social · 22/08/2025
So incredibly proud of my team and our collaborators. What a fantastic step forward for brain cancer clinical trials and mIDH inhibitors @braincancerlab @jimwhittle.bsky.social @saskiafreytag.bsky.social @wehi-research.bsky.social www.nature.com/articles/s41...
nature.com
Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial - Nature Medicine
This pilot trial showed that perioperative treatment with the isocitrate dehydrogenase (IDH) inhibitor safusidenib of patients with low-grade IDH-mutant glioma, with craniotomy and lumbar puncture bef...
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Sarah Best @sarahannbest.bsky.social · 14/01/2025
Excited to share the latest review paper out of our Brain Cancer lab! We focus a lot of our work on spatial heterogeneity and tumor microenvironment - but...how do you study it in practice? Read our review here discussing techniques and implications for GBM www.sciencedirect.com/science/arti...
sciencedirect.com
Spatial omics shed light on the tumour organisation of glioblastoma
The glioblastoma tumour microenvironment is characterised by immense heterogeneity, with malignant and non-malignant cells that interact in a complex …
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Sarah Best @sarahannbest.bsky.social · 13/01/2025
Now on BioRxiv: we explored patient-derived GBM organoids & spheroids generated from the same resected tissue. Critically, both models maintain tumor cell composition & heterogeneity, with comparable tissue resemblance across data modalities (1/4) www.biorxiv.org/content/10.1...
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