The Munson Lab researches the mechanistic basis for the regulation of spatial and temporal specificity in membrane trafficking in the Biochemistry & Molecular Biotechnology Department at UMass Chan Me...

New leader of the National Academy of Sciences Neil Shubin warns: ‘a society that loses science loses the future’.

On June 30, 2026, I sat at a witness table, under oath, in the Rayburn House Office Building in Washington, DC and testified before the House Oversight Committee’s Task Force on the Declassification o...

Russell Vought is going to destroy American Science

Williams et al. report structures of the MMM complex, a membrane-spanning E3 ligase. A single α helix suspends an activated RING domain below the plasma membrane to ubiquitylate the GPCR Smoothened and attenuate Hedgehog signaling. This work establishes a structural and mechanistic blueprint for how transmembrane E3s search and destroy key receptors in development, immunity, and metabolism.

“This erosion of our strength is a loss for the nation,” writes MIT President Sally Kornbluth.

Signal peptides are highly variable, yet the signal peptidase complex processes them with remarkable specificity. Here, authors combine cryo-EM, molecular dynamics simulations and modeling to reveal a...

Building on America’s 250-year-old commitment to knowledge, the American Academy of Arts & Sciences announces the leaders in academia, the arts, industry, journalism, philanthropy, policy, research, a...

Attacks on science and immigrants are destroying America.

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Funding for national laboratories and important research projects would increase under the government’s plans.

Funding for national laboratories and important research projects would increase under the government’s plans.

A common mechanism of inhibition of the essential lipid II flippase MurJ by three distinct phage-encoded single-gene lysis proteins provides insights into potential new targets for antimicrobial development.

Uruguay built a power grid that runs 99% on renewables—at half the cost of fossil fuels. Here’s how its bold energy overhaul became a global model.

Nature Structural & Molecular Biology - Mitochondrial translational activators (TAs) facilitate transcript-specific translation. Using selective ribosome profiling and cryo-electron microscopy,...

The seven-arm octopus is a rarely seen deep-sea giant who feeds on gelatinous animals.

Today, social media platforms hold the sole power to study the effects of feed-ranking algorithms. We developed a platform-independent method that reranks participants’ feeds in real time and used thi...

Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously "undruggable" proteins. Current d...

Phase separation is a mechanism for non-organellar macromolecule segregation typical in the cell cytosol and nucleus. Two recent studies revealed functional phase separation within the endoplasmic ret...

The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Nature - The structural mechanism of a natively isolated GRP94 folding intermediate tethered to a CCDC134-bound translocon is described, revealing how the nascent chain remodels the translocon to...

The GroEL/ES chaperonin can act during protein synthesis to promote folding. Here, Roeselová et al. show how GroEL captures, remodels and sequesters nascent proteins in its central chamber, while they...

The authors use selective ribosome profiling to define how and when factors for N-glycosylation and membrane insertion engage and disengage from the core Sec61 translocation channel during biogenesis ...

Nature Structural & Molecular Biology, Published online: 20 October 2025; doi:10.1038/s41594-025-01691-6The authors use selective ribosome profiling to define how and when factors for N-glycosylation and membrane insertion engage and disengage from the core Sec61 translocation channel during biogenesis of secretory and membrane proteins at the endoplasmic reticulum.

Development of LOV-domain-controlled ligase for translation localization (LOCL-TL), an optogenetic approach for monitoring translation with codon resolution at any defined subcellular location under p...

Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in human cells are imported during translation on cytosolic ribosomes. Cotranslational import requires an N-terminal pres...