An injectable contraceptive is under development in India, and U.S. companies are pursuing their own versions.

The big-box retailer said the money was reinvested to give "value back to our members." It’s more than a third of the total tariff refunds the company expects.

The procession came amid a fierce graffiti battle and sloganeering between Left-wing student groups and the RSS-affiliated ABVP at Jadavpur University, days after clashes between the two sides

YouTube video by NirvanaVEVO

As automated tools accelerate both the discovery and the exploitation of software vulnerabilities, organizations must redesign their defences and workflows to keep pace.

Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...

Regulation of membrane receptors governs extracellular matrix homeostasis and host-pathogen interactions. Here, authors show that reversible S-acylation controls CMG2 maturation, trafficking, and sign...

A lipid tag mediated via S-acylation redirects the precursor of a plant elicitor peptide to alter its fate upon cell wall damage.

After months out of prison, Frank Ross’ dementia has progressed. At times, he can no longer remember why he needs to wear the GPS monitor the law requires, putting his freedom at risk.

Don't let your leftovers go to waste. Cookbook authors share clever storage techniques — like an "Eat Me First" box in your fridge — and cooking tricks to help you make the most of your food scraps.

By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University

HCV infection poses a significant global health burden. Despite the remarkable efficacy of direct antiviral agents, developing new strategies targeting host factors is crucial for addressing drug resi...

Nature Structural & Molecular Biology - OSTα/β regulates bile acid and steroid conjugate homeostasis. Sun, Tian, Low and colleagues reveal structures of the human OSTα/β...

An experimental pill has shown unprecedented success in treating pancreatic cancer, upending conventional wisdom about the disease.

Mutations in superoxide dismutase 1 (SOD1) compromise its metal-binding capacity, resulting in protein misfolding and aggregation, which ultimately induces cellular apoptosis in amyotrophic lateral sc...

The conference provides predoctoral candidates and postdoctoral biophysics researchers the opportunity to explore resources and research opportunities at NIH.

Protein palmitoylation is an important lipidic post-translation modification catalyzed by the zDHHC protein acyltransferases. In this issue of Cell Ch…

Cholangiocarcinoma is a highly malignant tumor with an increasing incidence around the world. Discovery of novel molecular targets and effective thera…

Palmitoylation by ZDHHC18 blocks ORF3a K27-linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation thro....

Disrupted lipid signaling in neurons impairs brain connectivity, revealing a target for epilepsy, neurodevelopmental disorders.

TDP43 inclusion bodies are widely present in the majority of patients with familial and sporadic amyotrophic lateral sclerosis (ALS). The mechanisms r…

🙌 Congratulations to two NIH senior scientists on being elected as members to the U.S. National Academy of Sciences! Dr. Okihide Hikosaka serves as head of the Laboratory of Sensorimotor Research at ...

This study reveals that metabolic dysregulation in diabetes activates the ZDHHC9-ACSL4 pathway, triggering ferroptosis in penile fibroblasts and worsening erectile dysfunction. Targeting ZDHHC9 with ....

An important mechanism by which receptor tyrosine kinases (RTKs) mediate cellular responses involves the formation of signaling complexes through d...

N-Myc has historically been considered an undruggable target. Xu et al. reveal that the acyltransferase ZDHHC22 enhances N-Myc transcriptional activity through S-acylation. In turn, N-Myc transcriptio...

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